Basic Information

Transcription Factor Domain

TF Family: AF-4
Domain: AF-4 domain
PFAM: PF05110
TF Group: Unclassified Structure
Description: This family consists of AF4 (Proto-oncogene AF4) and FMR2 (Fragile X syndrome) nuclear proteins. These proteins have been linked to human diseases such as acute lymphoblastic leukaemia and mental disabilities [1]. The family also contains a Drosophila AF4 protein homologue Lilliputian which contains an AT-hook domain. Lilliputian represents a novel pair-rule gene that acts in cytoskeleton regulation, segmentation and morphogenesis in Drosophila [2].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 3 3e-09 6e-05 22.6 0.5 27 130 36 139 28 178 0.60

2 3 1 2e+04 -12.5 18.3 458 479 182 203 153 211 0.62

3 3 5.2e-07 0.011 15.2 0.1 342 381 250 289 227 300 0.82

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	3	3e-09	6e-05	22.6	0.5	27	130	36	139	28	178	0.60
2	3	1	2e+04	-12.5	18.3	458	479	182	203	153	211	0.62
3	3	5.2e-07	0.011	15.2	0.1	342	381	250	289	227	300	0.82

Coding Sequence: ATGTCGGTCCAGGCGGAGCAAGCGGCTGCAGGAGGAGGTCCTGACAGCCGTCACGGTCACCGTCATCACGGGCATCATCATGGACACCATCATCATTCGAATCCTCTTGCAGCCACCGGTCCGCTCTTTCGTGCTCCCGTGAGGGTAAATCCCGACGCACAGGATCGCGCTACTCAGCAGATCCAATCGAAGCTGGGCAATTACTCGCTGGTGAAGCACTTCGTACTCGACGACTCGAAGAGGCTCATCGGCATCGAGGGTGTCCCTGCGAGTCCCGCGCCAGCTTCAGCCTCCGCCCTGAGGACAAGTTCAAGTTCAGGGACGACCTCGAGAAGCTCACCGTCCGCCCAAGAATTTAAGAAACCTGGCGGTCCTCGCACGAGCTCCAGCGGATCGAGTAGTCACGCTTCTCAACGTGGTGGGTTCGTCAAACCGGCTGACGGGAAACCACCCTACAGTGGCAGGGGTAGCTACTCGGGACAACCCGTGAAACACGGTGGCAGCAGTAACGACCATCGCAGCCATGGGCTTCTTCCCGCCAAGGGTCCTCCCCCGaattcatcttcctcttcatcctctaCGTCAAGTATCACCTCTTCGTCCTCCTCGGCCAATCTCGGTGGGAACGCAAACTTTGACGGCATTGCTGGAAACGTCAACGCCGGAAGTACCGGTAGCAGGATACACTCGGTGGCTGGTCGACTGCCCAGGTTGCCTCTGGATAATGGAACGAATAGCCGGCACGGAGCTACCGAAAATTCTGCCGACCTCGAGAATATCCTGAAAGAGATGATGATGCCGCCGACTCCGCTGACGGCAATTGCACAGACCCCGAGGAAAGAACTGGAGTCAAAGTTCACTTTCAACCCTGTACTCGCCAAGcTGACCGAAGTCCCACCTGCCGAAGTCGCGAAGCCTCGTAAGTACACGCGCATCAATACTATCTAG
Protein Sequence: MSVQAEQAAAGGGPDSRHGHRHHGHHHGHHHHSNPLAATGPLFRAPVRVNPDAQDRATQQIQSKLGNYSLVKHFVLDDSKRLIGIEGVPASPAPASASALRTSSSSGTTSRSSPSAQEFKKPGGPRTSSSGSSSHASQRGGFVKPADGKPPYSGRGSYSGQPVKHGGSSNDHRSHGLLPAKGPPPNSSSSSSSTSSITSSSSSANLGGNANFDGIAGNVNAGSTGSRIHSVAGRLPRLPLDNGTNSRHGATENSADLENILKEMMMPPTPLTAIAQTPRKELESKFTFNPVLAKLTEVPPAEVAKPRKYTRINTI

Sequence clustering based on sequence similarity using MMseqs2