AF-4
- Domain
- AF-4 domain
- Group
- Unclassified Structure
- PFAM
- PF05110
- Desciption
- This family consists of AF4 (Proto-oncogene AF4) and FMR2 (Fragile X syndrome) nuclear proteins. These proteins have been linked to human diseases such as acute lymphoblastic leukaemia and mental disabilities [1]. The family also contains a Drosophila AF4 protein homologue Lilliputian which contains an AT-hook domain. Lilliputian represents a novel pair-rule gene that acts in cytoskeleton regulation, segmentation and morphogenesis in Drosophila [2].
- Rederence
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- Lilliputian: an AF4/FMR2-related protein that controls cell identity and cell growth. Wittwer F, van der Straten A, Keleman K, Dickson BJ, Hafen E. Development 128, 791-800, (2001).
- Transcriptional regulation of cytoskeletal functions and segmentation by a novel maternal pair-rule gene, lilliputian. Tang AH, Neufeld TP, Rubin GM, Muller HA. Development 128, 801-13, (2001).
Statistic of Transcription Factors
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Transcription Factor Table
| Gene ID | Insect | Gene Name | Gene Symbol |
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