Basic Information

Transcription Factor Domain

TF Family: E2F
Domain: E2F_TDP domain
PFAM: PF02319
TF Group: Helix-turn-helix
Description: This family contains the transcription factor E2F and its dimerisation partners TDP1 and TDP2, which stimulate E2F-dependent transcription. E2F binds to DNA as a homodimer or as a heterodimer in association with TDP1/2, the heterodimer having increased binding efficiency. The crystal structure of an E2F4-DP2-DNA complex shows that the DNA-binding domains of the E2F and DP proteins both have a fold related to the winged-helix DNA-binding motif. Recognition of the central c/gGCGCg/c sequence of the consensus DNA-binding site is symmetric, and amino acids that contact these bases are conserved among all known E2F and DP proteins.
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 3 1.3e-22 7.9e-19 67.9 0.1 1 65 52 118 52 118 0.93

2 3 1.3 7.6e+03 -2.5 0.0 11 29 124 141 123 143 0.70

3 3 8e-17 4.8e-13 49.4 0.1 1 64 153 243 153 244 0.89

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	3	1.3e-22	7.9e-19	67.9	0.1	1	65	52	118	52	118	0.93
2	3	1.3	7.6e+03	-2.5	0.0	11	29	124	141	123	143	0.70
3	3	8e-17	4.8e-13	49.4	0.1	1	64	153	243	153	244	0.89

Coding Sequence: ATGTATGAAAGTGAATACATAACTTCTACTCCAAAGCGGTATGCTCTTACTGAAGTCACAAACGCAAGTTATGTTTCTCCAACTGCTAACCTCAAGTTGTTGACTAATGTTGCACTACAGTATCCCACGCCGCCACCCAGCGCAGTACAtcgaaaagaaaaatctttgcAAATATTATGTGACAAatttctTAACCTGTATCCCCTTCAATGCAATGGAACCATGAAAATTCAATTGGACAGCACTGCAGCTAGACTGGGTGTAGAAAAACGCAGAATGTAtgacataattaatatattagaagCAATGAAGTATGCAGtccatgaaaagaaaaatacatatttatggaATGGAGAAGCAGGCCTaagttcatttttaaaattgttaaaaaaacaaggAGAAAATCTTCGTTTGTCTGAGGCCCTGAGAGGAAGGGCACCAAAGCCTCCTCCACCAAAACATAAAACCCTTGGTGTACTGGCAAAGAGATTTTTGATGTTGTTTTTAGTTGAACCGCAAAATACTTTAATCAATCTAGAAATGGCTGTGAGGGTACTTATAGACacatctaataaaaataaaactgatcTCTCACCAGAACAACTGGACCGGCAACACAAGTCTAAAGTAAGAAGACTGTATGATATtgctaatgtatttatatcaattggTCTCATAGAAAAAGTTTCTGGAAATTTGATATTGAAGAAGcctgtatttaaatatgtaggACGGTATAAAGTTAACAAGATTGATGTAACTACAATTGTAACACCATCACCTGTAACACCACTCTCTGCTTTAGACATACAACATAAATTAACCCCTTGCCATGTATATGCCGGTAGGTCTAGGCGAAAATTGGAGTTTACTACACTGAGTAATGAAACCAAATTAGGTGTTACCACACCTCCACACACACCATCACATAAATGGGATGAGATTTTGCTTGTAGCTGATATGGAGCTGAATAGAATTAACAATGGTGTTTTCTTGTGA
Protein Sequence: MYESEYITSTPKRYALTEVTNASYVSPTANLKLLTNVALQYPTPPPSAVHRKEKSLQILCDKFLNLYPLQCNGTMKIQLDSTAARLGVEKRRMYDIINILEAMKYAVHEKKNTYLWNGEAGLSSFLKLLKKQGENLRLSEALRGRAPKPPPPKHKTLGVLAKRFLMLFLVEPQNTLINLEMAVRVLIDTSNKNKTDLSPEQLDRQHKSKVRRLYDIANVFISIGLIEKVSGNLILKKPVFKYVGRYKVNKIDVTTIVTPSPVTPLSALDIQHKLTPCHVYAGRSRRKLEFTTLSNETKLGVTTPPHTPSHKWDEILLVADMELNRINNGVFL

Sequence clustering based on sequence similarity using MMseqs2