Basic Information

Gene Symbol
Lztr1
Assembly
GCA_029955525.1
Location
JARPMR010000008.1:6992971-7001158[-]

Transcription Factor Domain

TF Family
BTB
Domain
zf-C2H2|ZBTB
PFAM
PF00651
TF Group
Zinc-Coordinating Group
Description
The BTB (for BR-C, ttk and bab) [6] or POZ (for Pox virus and Zinc finger) [1] domain is present near the N-terminus of a fraction of zinc finger (Pfam:PF00096) proteins and in proteins that contain the Pfam:PF01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerisation and in some instances heteromeric dimerisation [1]. The structure of the dimerised PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule [2]. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT [5, 3, 4]. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 4 0.13 87 4.8 0.0 85 109 2 26 1 27 0.91
2 4 3.7 2.4e+03 0.2 0.0 77 108 26 57 23 59 0.84
3 4 3.1e-17 2e-14 55.1 0.0 9 97 122 210 119 225 0.87
4 4 0.78 5.1e+02 2.3 0.0 77 106 224 253 219 257 0.80

Sequence Information

Coding Sequence
ATGGAAGTCCTGCGGCTCGCTCTCCGCCTGAACATCCCGCGGCTGCGCGGGCTGTGCGCGCGCTACCTGCGCGCCAACCTGTGCTACAGCAACGTGCTGCAGGCGCTGCACGCCGCGCACCACGCCAACCTGGGCAGCATCAAGGAGTACTGCTTGCGGTTCGTAGTGAAGGACTACAACTTCACGGCCATCGTGATGTCGCCCGAGTTCGAGCAGATGGAGCAGAAGCTGATGGTGGAGGTGATCCgccgccgccaccagccgcAGCCGCACAAGCCGCCGCCCAACCACGACCAAGAGGAGGAGGTCATCGGTACCACGCTGGAGCAAGATATGTGCGTGTTCGTGGGCGGCGGGGGCGCGGACCTGGCGGACGTCAAGCTGCGAGTGGCGGGCGCCATGAAGCCGGCGCACCGCTCCATCCtggccgcgcgcgccgcctacTTCGAGGCCATGTTCCGCTCGTTCTCGCCGCAGGACAACGTTGTGAATATACAAATCTGCGACACGGTGCCATCGGAGGAGGCTTTCGACTCGCTGCTGAGGTACATATACTACGGCGATACCAACATGCCCACCGAAGACTCTCTGTACTTGTTCCAAGCGCCCATATATTACGgcttCACCAACAACCGTCTCCAAGTGTTCTGCAAGCACAATCTGCAGAGTAACGTGTCGCCAGACAACGTGCTCGCGATCCTGCAGGCGGCCGACCGCATGCACGCCGCCGACATCAAGGAGTACGCGCTCAAGATGATCGTGCATCACTTTGAACTGGTGGCTCGACAAGAAGCCATCAAGAACCTCGCCCAGCCTCTGCTGGTGGACATGATCTGGGCGCTTGCGGAGGAGCCCCGCTTCGACACGCAGCTCCCCCTGCAGCCACGCTCTCTCCCCTCCTCCTCCTCCGCAGACACCCTCGCCGAAGACCCAGACTACATGCGGCATAGATGCGGCAAGTAG
Protein Sequence
MEVLRLALRLNIPRLRGLCARYLRANLCYSNVLQALHAAHHANLGSIKEYCLRFVVKDYNFTAIVMSPEFEQMEQKLMVEVIRRRHQPQPHKPPPNHDQEEEVIGTTLEQDMCVFVGGGGADLADVKLRVAGAMKPAHRSILAARAAYFEAMFRSFSPQDNVVNIQICDTVPSEEAFDSLLRYIYYGDTNMPTEDSLYLFQAPIYYGFTNNRLQVFCKHNLQSNVSPDNVLAILQAADRMHAADIKEYALKMIVHHFELVARQEAIKNLAQPLLVDMIWALAEEPRFDTQLPLQPRSLPSSSSADTLAEDPDYMRHRCGK

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00874612; iTF_00779620;
90% Identity
iTF_00779620;
80% Identity
-