Basic Information

Transcription Factor Domain

TF Family: BTB
Domain: zf-C2H2|ZBTB
PFAM: PF00651
TF Group: Zinc-Coordinating Group
Description: The BTB (for BR-C, ttk and bab) [6] or POZ (for Pox virus and Zinc finger) [1] domain is present near the N-terminus of a fraction of zinc finger (Pfam:PF00096) proteins and in proteins that contain the Pfam:PF01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerisation and in some instances heteromeric dimerisation [1]. The structure of the dimerised PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule [2]. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT [5, 3, 4]. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 4 0.00032 0.11 12.9 0.0 67 109 2 55 1 56 0.89

2 4 3.8 1.3e+03 -0.2 0.0 78 108 56 86 53 88 0.82

3 4 5.4e-17 1.8e-14 54.0 0.0 9 97 149 237 146 251 0.86

4 4 0.18 61 4.0 0.1 77 107 251 281 240 284 0.82

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	4	0.00032	0.11	12.9	0.0	67	109	2	55	1	56	0.89
2	4	3.8	1.3e+03	-0.2	0.0	78	108	56	86	53	88	0.82
3	4	5.4e-17	1.8e-14	54.0	0.0	9	97	149	237	146	251	0.86
4	4	0.18	61	4.0	0.1	77	107	251	281	240	284	0.82

Coding Sequence: ATGGtcctcaattatatttatacggaTAGAATTGATCCTACTGAGAAAGATGAGGACCCAGCATCTCCAGCCACGATCCTTCTAGTGATGGAAGTGCTGCGGCTCGCTCTGAGGTTGAACATCCCGCGACTACGCGGGCTTTGTGCCCGCTACCTCCGCGCCAACCTCTGCTATAGCAACGTGCTGCAAGCGCTGCACGCGGCGCATCACGCGAATTTGACATGTATTAAAGAGTACTGTCTGAGGTTTGTTGTGAAAGACTACAATTTTACAGCAATAGTGATGTCGTCGGAGTTCGAACAAATGGATCAACGATTGATGGTCGAAGTGATACGTCGTCGACATCAACCGACTAACAAAATGCCCGCCAACGAACAGGAAGAGGAAGTTATAGGCACAACACTGGAACAAGACATGTGCGTGTTcgtgggcggcggcggcgcggagCTCGCCGACGTTAAGCTCCGCGTGGCGGGCGCGGCGCGGCCCGCGCACCGCTCCATACTGGCAGCCCGAGCGGCGTACTTCGAAGCTATGTTTAGATCTTTCTCACCACAGGATAATCTTGTTAATATTCAAATCTGTGATACGGTGCCGTCAGAGGAGGCATTCGACTCTCTTCTCCGTTACATCTACTATGGAGACACTAACATGCCCACTGAGGACTCACTTTATTTATTCCAAGCACCTATATATTACGGTTTCACGAACAATCGCCTCCAAGTGTTCTGCAAACATAACCTACAAAGCAACGTGTCGCCGGAGAACGTGCTCGCCATTTTACAAGCGGCCGACCGCATGCGCGCGCAGGACATAAAGGAGTACGCGTTGAAGATGATCGTTCACCATTTTGAATCTGTCGCTCGTCAAGATGCAATCAAAAACTTAGCTCAGCCATTGCTAGTGGATATAATATGGGCATTGGCTGAAGAACCACGTTTCGACACTCCACTACCCCTCCAACCGAGATCCTTGCCGTCTTCATCATCAGCGGACACCCTCACCGATGACCCTGAATATACACGTTATAAATCTACCAAATAA
Protein Sequence: MVLNYIYTDRIDPTEKDEDPASPATILLVMEVLRLALRLNIPRLRGLCARYLRANLCYSNVLQALHAAHHANLTCIKEYCLRFVVKDYNFTAIVMSSEFEQMDQRLMVEVIRRRHQPTNKMPANEQEEEVIGTTLEQDMCVFVGGGGAELADVKLRVAGAARPAHRSILAARAAYFEAMFRSFSPQDNLVNIQICDTVPSEEAFDSLLRYIYYGDTNMPTEDSLYLFQAPIYYGFTNNRLQVFCKHNLQSNVSPENVLAILQAADRMRAQDIKEYALKMIVHHFESVARQDAIKNLAQPLLVDIIWALAEEPRFDTPLPLQPRSLPSSSSADTLTDDPEYTRYKSTK

Sequence clustering based on sequence similarity using MMseqs2