Basic Information

Transcription Factor Domain

TF Family: BTB
Domain: zf-C2H2|ZBTB
PFAM: PF00651
TF Group: Zinc-Coordinating Group
Description: The BTB (for BR-C, ttk and bab) [6] or POZ (for Pox virus and Zinc finger) [1] domain is present near the N-terminus of a fraction of zinc finger (Pfam:PF00096) proteins and in proteins that contain the Pfam:PF01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerisation and in some instances heteromeric dimerisation [1]. The structure of the dimerised PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule [2]. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT [5, 3, 4]. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 4 0.038 26 6.3 0.0 83 109 17 43 12 44 0.91

2 4 0.9 6.3e+02 1.9 0.1 80 108 46 74 41 76 0.87

3 4 1.1e-16 7.7e-14 53.1 0.0 9 88 139 215 135 236 0.81

4 4 0.39 2.7e+02 3.0 0.0 77 106 236 265 230 269 0.80

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	4	0.038	26	6.3	0.0	83	109	17	43	12	44	0.91
2	4	0.9	6.3e+02	1.9	0.1	80	108	46	74	41	76	0.87
3	4	1.1e-16	7.7e-14	53.1	0.0	9	88	139	215	135	236	0.81
4	4	0.39	2.7e+02	3.0	0.0	77	106	236	265	230	269	0.80

Coding Sequence: ATGCCTTAcaagaATGAAGACCCAGCATCCCCGGCCACGATATTACTGGTGATGGAAGTACTTCGTCTAGCTCTCAGGCTGAACATACCCCGGCTGAGGGGTCTCTGTGCTCGGTACCTGCGGGCTAACCTCGGCTACGAGAACGTTCTGCAAGCCCTCCATGCCGCAGACCACGCCAACTTGCAGTCCATCAAGGAGTACTGCTTGAGGTTCGTGGTAAAAGATTACAACTTCACGCCAATTGTGATGTCGACAGAGTTTGAGCAGATGGAGCAGAAGCTAATGGTGGAAGTGATAAGACGCAGGCAACAGCCGTCTTGCAAACAGCCAGCTGTCAACCATGACTGCGAGGAGGAGATTACTGgCACAACTCTCGAGCAAGATATGTGCGTTTTCGTGAGCGGCGGGGGCTCCGACCTGGCGGACGTTAAGTTGAGAGTTGGGAGCTCTATGAGGCCCGCGCACCGCTCCATATTGGCAGCACGGGCCGCCTACTTCGAGGCTATGTTCCGCTCCTTCTCTCCGCAGGACAACGTCGTCAATATTCAAATCTGCGACACGATTCCTTCAGAGGAGGCTTTCGACTCATTGCTCCGTTACATGTACTACGGAGACACGAATATGCCGACAGAGGACTCNNNNNNNNNNAAAACCCGCTTCACCAACAATCGTCTGCAAGTGTTTTGCAAACACAATCTGCAAAGCAACGTGTCTCCAGAAAACGTGGTCGCCATCCTGCAGGCAGCAGATCGCATGCGAGCCGCTGACATCAAGGAGTACGCCCTGAAGATGATCGTCCATCACTTCGAGTTGGTTGCCCGGCAAGAGGCCATACGTAGCTTACCACAGCCTTTACTAGCGGATATAATATCGGCGCTGGTGGAGGAACCACGGCAAGACACTCCTCTTCCTCGCTCCCTCCCCAGCTCCAGTTCAGCAGACCAGCTTGCTGATGAAGATTATACAAGGCATAGAAGCGGGAAGTAA
Protein Sequence: MPYKNEDPASPATILLVMEVLRLALRLNIPRLRGLCARYLRANLGYENVLQALHAADHANLQSIKEYCLRFVVKDYNFTPIVMSTEFEQMEQKLMVEVIRRRQQPSCKQPAVNHDCEEEITGTTLEQDMCVFVSGGGSDLADVKLRVGSSMRPAHRSILAARAAYFEAMFRSFSPQDNVVNIQICDTIPSEEAFDSLLRYMYYGDTNMPTEDSXXXKTRFTNNRLQVFCKHNLQSNVSPENVVAILQAADRMRAADIKEYALKMIVHHFELVARQEAIRSLPQPLLADIISALVEEPRQDTPLPRSLPSSSSADQLADEDYTRHRSGK

Sequence clustering based on sequence similarity using MMseqs2