Basic Information

Insect: Oegoconia quadripuncta
Gene Symbol: foxn4_1
Assembly: GCA_949316235.1
Location: OX438753.1:7668244-7674570[-]

Transcription Factor Domain

TF Family: Fork_head
Domain: Fork_head domain
PFAM: PF00250
TF Group: Helix-turn-helix
Description: The fork head domain is a conserved DNA-binding domain (also known as a winged helix) of about 100 amino-acid residues. Drosophila melanogaster fork head protein is a transcription factor that promotes terminal rather than segmental development, contains neither homeodomains nor zinc-fingers characteristic of other transcription factors [1]. Instead, it contains a distinct type of DNA-binding region, containing around 100 amino acids, which has since been identified in a number of transcription factors (including D. melanogaster FD1-5, mammalian HNF-3, human HTLF, Saccharomyces cerevisiae HCM1, etc.). This is referred to as the fork head domain but is also known as a 'winged helix' [1, 2, 3]. The fork head domain binds B-DNA as a monomer [2], but shows no similarity to previously identified DNA-binding motifs. Although the domain is found in several different transcription factors, a common function is their involvement in early developmental decisions of cell fates during embryogenesis [3].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 1 2.7e-36 4.7e-33 114.1 0.1 2 84 303 386 302 390 0.93

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	1	2.7e-36	4.7e-33	114.1	0.1	2	84	303	386	302	390	0.93

Sequence Information

Coding Sequence: ATGGATCTGTACATCACCGATTCACTGCAGGATATGCTGGATATggacattaaaaatgaaatagctACGGATCTTAGCAGTATCACGGATTTTTCTGATTCGCTAGGATTAAATTTTTCTGAAATGCCACCGTTATTGGACATGGATACCGATAACTCTGCCACTTGGTTAAACAATTCTTCCAGTTTTGTTCATAATCTTGATTTGTATGGCTCAGAAGCTAATGCCGTAATGGTTAATCCAAATTCTGTGATGCCCTCAACCTTCGCGGAAACCCCCGTAAAAAGCATCGTGAAAGAAGAAGCGTCAAATTTATTACTGACTTCAGCTGCAGCTGCTGATAGCGACTTAAATAGTAATTCATCATTACCAAGTCCAAAAGAAGAAAAAAGTCATTTAACGTTTTCTCCTAATGCAATCAAAGTTTCGAAAGTAAAAGAACCCGAAGAAACGGCACCCAAAAAGGTTTTAGAAGAAGCCACTCAAATGGTAATTTATGTTCGAAAGCAGGATAAATCAGTGGTTAAAGATTTATTGAAAGACTTAGACAAGTCCAAAATAGGAAGTTTGCAAAACAACGGACAGTCTGTACGAATAAAATCGTCTCAATCAGAAGTACTTAAAGTGAATAACAAAAATTGTTCTATTATAAATACCAGTCAAAAAGTGACGCAACAAATAGGATCTAAGACCATTATTTCTGGTAATATACACATATTGGATGCTCAACAATCTAGGACAATTTTAGCAAATGGTAACAAAAATCAAGCTACAATATTGATCGATAATTCATCATTAAGTAATAAtagacaaataataaaatccgCTGTCAGTGGAGCGTTTACAGTTGATAGTAGCCAAGCTAAATATGTAAATTCTAGTAAAAACACCGTGGGAGAATATCCTAAGCCTGCATATTCTTATTCATGCCTAATAGCCATGGCGCTAAAGAATTCAAGAACAGGAAGTCTGCCTGTTTCAGAAATTTATAACTTCATGTGTCAgcattttccttattttaaaACGGCTCCAAATGGCTGGAAAAACTCTGTTAGGCATAACCTTAGCCTAAACAAATGttttgaaaaaattgaaaaaccGTCTACAAatggaagtcaaagaaaagGTTGTTTATGGGCAATGAATCCATCAAAAGTAGGAAAAATGGATGAAGAAGTCCAGAAATGGTCACGAAAAGACCCTCAAGCGATTAAGAAGGCCATGGTTTATCCAGAGAGCCTCGAGGCCCTAGAGCGGGGTGAGATGAAGTACAGCGGCGCTGGCGGCGACACCGACCCAGACGACGACGCCGACGTCGACGCTGACGCCGATACTGAGCTCGATGCCGATGTTGAAATAGATCCGGAGGTTAAAGAGGAGGTCGAAGAAGAAGAGGCTATTATTGAACAGGACATGTATGACCAAGAATTGGAGGTGGAGGAGGTGGTGGAAGGCACTGGTATGGTGGGAGGCACGTACCGATTGCTGGCGACCGGTCCTTCGTCACTCACTTCATACATTACCGACGTAGAGTCCAGTGAAGAGGTCAGCGATATTGAgGTTCTAGATCATTCATATGAAGAGATAGACATAGATGTAACGAAACCTATGAAGCTAGATCTTTCTTTGACTGAGAACTATACACTGCACTCAGCAAAGCGAGCAAAAACAAGCTTCATCTATCAGCCAGTGTCGACTCAAACACATACAAGTAGACGGAAAACGCCTCTCGTCAACAGAGTtgcattaatttaa
Protein Sequence: MDLYITDSLQDMLDMDIKNEIATDLSSITDFSDSLGLNFSEMPPLLDMDTDNSATWLNNSSSFVHNLDLYGSEANAVMVNPNSVMPSTFAETPVKSIVKEEASNLLLTSAAAADSDLNSNSSLPSPKEEKSHLTFSPNAIKVSKVKEPEETAPKKVLEEATQMVIYVRKQDKSVVKDLLKDLDKSKIGSLQNNGQSVRIKSSQSEVLKVNNKNCSIINTSQKVTQQIGSKTIISGNIHILDAQQSRTILANGNKNQATILIDNSSLSNNRQIIKSAVSGAFTVDSSQAKYVNSSKNTVGEYPKPAYSYSCLIAMALKNSRTGSLPVSEIYNFMCQHFPYFKTAPNGWKNSVRHNLSLNKCFEKIEKPSTNGSQRKGCLWAMNPSKVGKMDEEVQKWSRKDPQAIKKAMVYPESLEALERGEMKYSGAGGDTDPDDDADVDADADTELDADVEIDPEVKEEVEEEEAIIEQDMYDQELEVEEVVEGTGMVGGTYRLLATGPSSLTSYITDVESSEEVSDIEVLDHSYEEIDIDVTKPMKLDLSLTENYTLHSAKRAKTSFIYQPVSTQTHTSRRKTPLVNRVALI

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_01336641; iTF_00942626; iTF_00194995; iTF_00027577; iTF_00026662; iTF_00640099; iTF_01302106; iTF_00177894; iTF_00275063; iTF_01403257; iTF_00277190; iTF_00287879; iTF_01010184; iTF_00341154; iTF_00063396; iTF_01316135; iTF_01317095; iTF_00428818; iTF_00427912; iTF_00818968; iTF_01429752; iTF_00858363; iTF_01487528; iTF_00185955; iTF_00000132; iTF_01151877; iTF_00000998; iTF_00185126; iTF_01487529; iTF_00049714; iTF_00326901; iTF_01538554; iTF_01377285; iTF_00017993; iTF_00383436; iTF_01259894; iTF_01506984; iTF_01078892; iTF_01507884; iTF_00824525; iTF_01506157; iTF_01078008; iTF_01079712; iTF_01033537; iTF_01034349; iTF_00842466; iTF_00353893; iTF_00352854; iTF_01080550; iTF_00204946; iTF_01021005; iTF_01151040; iTF_00796340; iTF_00843317; iTF_00958522; iTF_00959230; iTF_00959986; iTF_00166762; iTF_00323306; iTF_01083115; iTF_00723788; iTF_00896589; iTF_00777826; iTF_00779335; iTF_00775081; iTF_00781641; iTF_00778608; iTF_00776594; iTF_00780082; iTF_00780855; iTF_00775871; iTF_01401099; iTF_00621039; iTF_00827795; iTF_00985813; iTF_00774328; iTF_01181720; iTF_01073421; iTF_00012751; iTF_00642159; iTF_00674127; iTF_00994186; iTF_00806509; iTF_00832720; iTF_00647814; iTF_00011758; iTF_01359536; iTF_00007825; iTF_00736437; iTF_00247858; iTF_00722857; iTF_00212244; iTF_00247001; iTF_00159646; iTF_00457063; iTF_00457831; iTF_00213236; iTF_01358706; iTF_00859276; iTF_00006899; iTF_00761442; iTF_01436834; iTF_01251562; iTF_01416587; iTF_01415637; iTF_01017556; iTF_01361396; iTF_01362908; iTF_00432949; iTF_00431947; iTF_00446933; iTF_00445924; iTF_01075189; iTF_00113943; iTF_00113153; iTF_00112328; iTF_00186959; iTF_00157015; iTF_00932232; iTF_00677355; iTF_00822701; iTF_01501901; iTF_00636085; iTF_00794135; iTF_00823739; iTF_00931037; iTF_01197536; iTF_01435874; iTF_00706759; iTF_01360423; iTF_01332360; iTF_01166411; iTF_00621837; iTF_01491693; iTF_00889006; iTF_00280946; iTF_00282082; iTF_00441298; iTF_00908627; iTF_00821592; iTF_00404508; iTF_00869437; iTF_01424862; iTF_00345632; iTF_01312055; iTF_01500919; iTF_00844134; iTF_00276088; iTF_00354904; iTF_00355943; iTF_01091512; iTF_00801615; iTF_00461372; iTF_01179320; iTF_01180142; iTF_01173090; iTF_01437785; iTF_00970223; iTF_00971049; iTF_01152858; iTF_01438714; iTF_00782458; iTF_00150300; iTF_00072541; iTF_01220471; iTF_00444925; iTF_00785832; iTF_00783242; iTF_00784209; iTF_01285361; iTF_00785017; iTF_00708990; iTF_00207679; iTF_00208648; iTF_00673311; iTF_00025092; iTF_01338303; iTF_00040609; iTF_00745442; iTF_00667171; iTF_00757955; iTF_01531779; iTF_00425189; iTF_01062569; iTF_01532843; iTF_00711629; iTF_00042446; iTF_01092882; iTF_00071219; iTF_01534611; iTF_01533749; iTF_00300984; iTF_00039609; iTF_00041594; iTF_00928474; iTF_01094714; iTF_00301915; iTF_00122172; iTF_00121213; iTF_00685246; iTF_01093854; iTF_01339774; iTF_01061696; iTF_01084064; iTF_00237281; iTF_01064449; iTF_01025794; iTF_00172547; iTF_00363843; iTF_00905929; iTF_00907695; iTF_00038512; iTF_01342035; iTF_01525748; iTF_00036438; iTF_00037592; iTF_00906876; iTF_00622627; iTF_01030947; iTF_00448836; iTF_01440804; iTF_00830982; iTF_00147116; iTF_00120305; iTF_01246641; iTF_00952518; iTF_00951609; iTF_01029031; iTF_01076200; iTF_00771689; iTF_00850409; iTF_00468010; iTF_00467271; iTF_01027114; iTF_01028076; iTF_00888030; iTF_00787437; iTF_00851533; iTF_01526833; iTF_00809874; iTF_01425778; iTF_00273427; iTF_00124052; iTF_01029972; iTF_00726101; iTF_00171574; iTF_00449938; iTF_00274262; iTF_01230326; iTF_00808919; iTF_01118071; iTF_01119094; iTF_01192439; iTF_01264215; iTF_00111416; iTF_01084952; iTF_00077305; iTF_01116985; iTF_00176923; iTF_00299964; iTF_00373726; iTF_00374992; iTF_01439711; iTF_00973536; iTF_01443647; iTF_00146208;
90% Identity: iTF_00806509; iTF_00027577; iTF_00026662;
80% Identity: -