Clig004184.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Craniophora ligustri
Gene Symbol
Foxn1
Assembly
GCA_905163465.1
Location
LR990959.1:11174559-11179447[+]

Transcription Factor Domain

TF Family
Fork_head
Domain
Fork_head domain
PFAM
PF00250
TF Group
Helix-turn-helix
Description
The fork head domain is a conserved DNA-binding domain (also known as a winged helix) of about 100 amino-acid residues. Drosophila melanogaster fork head protein is a transcription factor that promotes terminal rather than segmental development, contains neither homeodomains nor zinc-fingers characteristic of other transcription factors [1]. Instead, it contains a distinct type of DNA-binding region, containing around 100 amino acids, which has since been identified in a number of transcription factors (including D. melanogaster FD1-5, mammalian HNF-3, human HTLF, Saccharomyces cerevisiae HCM1, etc.). This is referred to as the fork head domain but is also known as a 'winged helix' [1, 2, 3]. The fork head domain binds B-DNA as a monomer [2], but shows no similarity to previously identified DNA-binding motifs. Although the domain is found in several different transcription factors, a common function is their involvement in early developmental decisions of cell fates during embryogenesis [3].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 1 2.6e-36 4e-33 114.1 0.1 2 84 304 387 303 391 0.93

Sequence Information

Coding Sequence
ATGGATTTATATATCACAGATTCACTCCAGGATATGCTGGACATGGATATTAAAAATGAGATTGCAACAGACCTTAGCAGTATGACAGATTTTGCAGATACATTGGGCTCACACTTCTCCGAGTTGCCCCCATTAATAGACATGGACACTGATAATTCTGCCACATGGCTTAATAATAGTTCTAGCTTCGTTCATAACCTAGATTTATATGGATCGGAAGCAAATGCAGTAATGGTTAATCCTAATTCTGTAATGCCATCTACATTTGTTGAAACTCCAGTTAAAAGCATAGTGAAAGAAGAGGCCTCGAACTTATTACTAACATCAGCGGCTACTAACGACGATTTAAGTAATAGTATATCACTACCAAGTCCCAAAGAAGAAAAAAGCCATCTAACATTTTCTCCCAATACGATAAAAGTATCAAAAGTTCAAGAACCAGAAGAGCCAAAAGTCAAGAAAAATTCGGACATAGAAGAAGCCACACAAATGGTGATTTATGTAAGAAAACATGAAAAAAATGTTGTTAAGGATTTGTTAAAAGACTTGGATAAGTCCAAAGTATCCAATATATCAACTGCAACTACAGTCAGAATAAAAAGCCAATCAGAATTAATAAAAGTGAACAACAAAAGCTGTTCTATTTTAAATACAAGCCAAAAAGTTGCACACTCAATAGGAACAAAAACCATCATTTCTGGTAATATACACATACTGGATCCTCAACAAATAAATCATAGTAGAACAATTTTAGCAAATGGTAATAAAAACCAAGCAACAATATTAATTGACAATTCGTCGTTAAATAACAATAGGCAAATAATTAAAACTTCAGTAAATGGAGGATTTACGTTAGATACTAGCCAAACAAAATATATAAATAGTAAAAGTAATGTTGGAGAATTTCCTAAGCCAGCGTATTCATATTCATGTTTAATAGCAATGGCTTTGAAAAACTCAAGAACAGGTAGCCTGCCTGTTTCAGAAATTTATAATTTTATGTGTCAGCATTTCCCTTATTTTAAAACCGCGCCAAATGGTTGGAAGAATTCCGTGAGGCACAATCTAAGTTTGAACAAATGTTTTGAAAAGATAGAAAAACCATCAACTAATGGAAGTCAAAGAAAAGGTTGTCTATGGGCTATGAATCCCTCGAAAGTAGGGAAAATGGACGAAGAAGTTCAAAAGTGGTCACGGAAAGATCCGCAAGCTATCAAAAAGGCGATGGTTTATCCAGAAAATTTAGAGGCTCTCGAAAGGGGTGAAATGAAATACAGCGGCGTGAGCGGCGATAACGAGGGTGATGATGATGCTGATGTTGACGCTGATACAGAGCTCGACGCGGATGTTGAAATTGACCCTGAAGTCAAAGAAGAAGTAGAAGAGGAAGAAGCTATTATAGAACAGGAGGTGTCTGATCAAGAATTAGAGGTTGAAGAGGTAGAAGGGACAGGTATGGTGGGCGGCACATACAGGTTGCTAGCAACGGGGCCGTCTTCACTTACTTCTTACATAACTGATGTAGAATCTTGCGAGGAAGTCAGTGACATTGAGGTACTAGATCAATCGTATGAAGAAATCGACATTGATGTTACAAAACCCATGAAATTAGACTTGTCTATGACAGAAAATTATACAATACATCAAACGAAACGAGCAAAAACAAGTTTCATCTATCAACCAGTGACGACACAGACTCATACTAGTAGAAGAAAAACGCCTCTTGTTAACCGAGTCGCATTAATATAA
Protein Sequence
MDLYITDSLQDMLDMDIKNEIATDLSSMTDFADTLGSHFSELPPLIDMDTDNSATWLNNSSSFVHNLDLYGSEANAVMVNPNSVMPSTFVETPVKSIVKEEASNLLLTSAATNDDLSNSISLPSPKEEKSHLTFSPNTIKVSKVQEPEEPKVKKNSDIEEATQMVIYVRKHEKNVVKDLLKDLDKSKVSNISTATTVRIKSQSELIKVNNKSCSILNTSQKVAHSIGTKTIISGNIHILDPQQINHSRTILANGNKNQATILIDNSSLNNNRQIIKTSVNGGFTLDTSQTKYINSKSNVGEFPKPAYSYSCLIAMALKNSRTGSLPVSEIYNFMCQHFPYFKTAPNGWKNSVRHNLSLNKCFEKIEKPSTNGSQRKGCLWAMNPSKVGKMDEEVQKWSRKDPQAIKKAMVYPENLEALERGEMKYSGVSGDNEGDDDADVDADTELDADVEIDPEVKEEVEEEEAIIEQEVSDQELEVEEVEGTGMVGGTYRLLATGPSSLTSYITDVESCEEVSDIEVLDQSYEEIDIDVTKPMKLDLSMTENYTIHQTKRAKTSFIYQPVTTQTHTSRRKTPLVNRVALI

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01090505;
90% Identity
iTF_00237281; iTF_01025794; iTF_00172547; iTF_00363843; iTF_00622627; iTF_01030947; iTF_00448836; iTF_01440804; iTF_00830982; iTF_00952518; iTF_01029031; iTF_00905929; iTF_01027114; iTF_00147116; iTF_00907695; iTF_00038512; iTF_00374992; iTF_00120305; iTF_01246641; iTF_01526833; iTF_00809874; iTF_00273427; iTF_01029972; iTF_01525748; iTF_00726101; iTF_00036438; iTF_00274262; iTF_01119094; iTF_01230326; iTF_00808919; iTF_01118071; iTF_01192439; iTF_00037592; iTF_00951609; iTF_01116985; iTF_00176923; iTF_00906876; iTF_00373726; iTF_01439711; iTF_00973536; iTF_00040609; iTF_00043299; iTF_00042446; iTF_00039609; iTF_00041594; iTF_01064449; iTF_01062569; iTF_00711629; iTF_00444925; iTF_00685246; iTF_01061696; iTF_01092882; iTF_00667171; iTF_00757955; iTF_01094714; iTF_01093854; iTF_00071219; iTF_01534611; iTF_01533749; iTF_01531779; iTF_01532843; iTF_00300984; iTF_00928474; iTF_00301915; iTF_00122172; iTF_00121213; iTF_00017158; iTF_01377285; iTF_00017993; iTF_01342035; iTF_00785832; iTF_00783242; iTF_00784209; iTF_01285361; iTF_00785017; iTF_00280946; iTF_00282082; iTF_00449938; iTF_01259894; iTF_01332360; iTF_00850409; iTF_00851533; iTF_00299964; iTF_01028076; iTF_00888030; iTF_01361396; iTF_01264215; iTF_01076200; iTF_00111416; iTF_01538554; iTF_01338303; iTF_00745442; iTF_00425189; iTF_01339774; iTF_00185955; iTF_00185126; iTF_00000132; iTF_00000998; iTF_00445924; iTF_01487528; iTF_01487529; iTF_00326901; iTF_00771689; iTF_00049714; iTF_00124052; iTF_00446933; iTF_00171574; iTF_01084952; iTF_01362908; iTF_01424862; iTF_01084064;
80% Identity
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