Pmus007359.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Pelosia muscerda
Gene Symbol
foxn4
Assembly
GCA_963691645.1
Location
OY829104.1:11489403-11492348[-]

Transcription Factor Domain

TF Family
Fork_head
Domain
Fork_head domain
PFAM
PF00250
TF Group
Helix-turn-helix
Description
The fork head domain is a conserved DNA-binding domain (also known as a winged helix) of about 100 amino-acid residues. Drosophila melanogaster fork head protein is a transcription factor that promotes terminal rather than segmental development, contains neither homeodomains nor zinc-fingers characteristic of other transcription factors [1]. Instead, it contains a distinct type of DNA-binding region, containing around 100 amino acids, which has since been identified in a number of transcription factors (including D. melanogaster FD1-5, mammalian HNF-3, human HTLF, Saccharomyces cerevisiae HCM1, etc.). This is referred to as the fork head domain but is also known as a 'winged helix' [1, 2, 3]. The fork head domain binds B-DNA as a monomer [2], but shows no similarity to previously identified DNA-binding motifs. Although the domain is found in several different transcription factors, a common function is their involvement in early developmental decisions of cell fates during embryogenesis [3].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 1 1.2e-36 1.5e-33 115.4 0.1 2 87 305 391 304 392 0.94

Sequence Information

Coding Sequence
ATGGATTTATACATCACTGATTCACTCCAGGACATGCTGGACATGGACATTAAGAATGAAATTGCTACAGATCTTAGCAGTATGACGGATTTTCAAgaTTCTTTAGGAACAAATTTCTCGGAATTGCCCCCTTTACTAGATATGGACACCGATAACTCTGCAACATGGCTTAATAATAGTTCTAGTTTTGTCCATAACCTTGATTTATATGGTTCGGAAGCAAACGCTGTAATGGTTAATCCAAATTCTGTCATGCCATCTTCGTTTGTGGAAACTCCTGTTAAAAGTATAGTTAAAGAAGAAGCTTCAAATTTATTACTGACTTCTGCGGCTGCTGATGACGATTTGAGCAACAACATATCACTTCCGAGTCCCAAAGAAGAAAAAAGTCACTTAACATTTTCCCCTAATGCAATTAAAGTGCCAAAAGTACAAGAACCAGAAGAATCGACAGTCAAGAAGAGCTCTGAACTAGAAGAAGCGACACAGATGGTAATTTATGTTAGAAAACATGAGAAAAGCGTGGTTAAGGATTTGTTAAAAGATTTGGACAaaatgaaaaattcaaatatagcTCAATCAACCACCGTGCGAATAAAAAGTCAATCTGaattaataaaagtaaacaataagaACTGTTCAATCTTGAACGCAAACCAAAAAGTTTCGCAGGCGTTAGGGACGAAGACAATAATATCGGGCAACATACACATATTGGATGCTCATCAAATCAGCCACTCTAGAACAATTTTAGCCAATGGTAACAAAAATCAGGCTACTATATTAATTGATAATTCATCGATAAATAATAGACATATAATTAAACCCTCAGCGAGTGGTGGATTCACAGTAGAAAATAGCCAAtctaaatatgtaaatacttcTAGTAAAAATGGTAGTGGAGAATTTCCTAAGCCCGCATATTCTTATTCCTGTTTAATAGCAATGGCTTTGAAAAATTCAAGAACAGGTAGCTTACCTGTTTccgaaatttataattttatgtgTCAACATTTCCCATACTTTAAAACTGCACCAAATGGTTGGAAAAATTCCGTTAGACATAATCTTAGTCTAAacaaatgttttgaaaaaattGAAAAGCCTTCCACAAATGGAAGTCAAAGAAAAGGATGCTTATGGGCAATGAATCCAGCTAAAATCGAGAAAATGGATGAAGAAGTACAAAAATGGTCACGGAAAGACCCACAAGCAATTAAAAAGGCCATGGTTTATCCAGAAAATTTAGAGGCTTTAGAACGAGGTGAAATGAAGTATAGTGGAGTAGGCGGCGATGCTGATGTAGATGATGATGCCGACGTTGACGCCGATGTTGAACTTGACGCTGACGTAGAAATTGATCCAGAAGTCAAAGAAGAAGTTGAAGAAGAAGAGGCTATTATAGAACAGGAAATATCAGACCAGGAGTTAGAAGTAGAAGAGGTAGTAGAAGGAACTGGTATGGTTGGTGGTACTTACCGGCTACTAGCTACTGGACCTTCATCGCTTACGTCCTATATAACTGATGCTGAATCTGGCGAGGAAGTTAGTGATATTGAAGTACTAGACCAGTCATATGAAGAATTTGACATTGATGTTACAAAACCCGTAAAATTAGACTTATCAATGACAGAAAATTATACTATTCACCCAGCAAAACGAGCAAAAACTAACTTTATTTATCAACCCGTGACAACTCAGACACATACTAGTAGAAGAAAAACGCCTCTTGTCAATAGGGTggcattaatataa
Protein Sequence
MDLYITDSLQDMLDMDIKNEIATDLSSMTDFQDSLGTNFSELPPLLDMDTDNSATWLNNSSSFVHNLDLYGSEANAVMVNPNSVMPSSFVETPVKSIVKEEASNLLLTSAAADDDLSNNISLPSPKEEKSHLTFSPNAIKVPKVQEPEESTVKKSSELEEATQMVIYVRKHEKSVVKDLLKDLDKMKNSNIAQSTTVRIKSQSELIKVNNKNCSILNANQKVSQALGTKTIISGNIHILDAHQISHSRTILANGNKNQATILIDNSSINNRHIIKPSASGGFTVENSQSKYVNTSSKNGSGEFPKPAYSYSCLIAMALKNSRTGSLPVSEIYNFMCQHFPYFKTAPNGWKNSVRHNLSLNKCFEKIEKPSTNGSQRKGCLWAMNPAKIEKMDEEVQKWSRKDPQAIKKAMVYPENLEALERGEMKYSGVGGDADVDDDADVDADVELDADVEIDPEVKEEVEEEEAIIEQEISDQELEVEEVVEGTGMVGGTYRLLATGPSSLTSYITDAESGEEVSDIEVLDQSYEEFDIDVTKPVKLDLSMTENYTIHPAKRAKTNFIYQPVTTQTHTSRRKTPLVNRVALI

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01090505;
90% Identity
iTF_00908627; iTF_01491693; iTF_01151877; iTF_00869437; iTF_00441298; iTF_01360423; iTF_00157015; iTF_00677355; iTF_00822701; iTF_00636085; iTF_00794135; iTF_00823739; iTF_01197536; iTF_01435874; iTF_00706759; iTF_01501901; iTF_00404508; iTF_00821592;
80% Identity
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