Fork_head
- Domain
- Fork_head domain
- Group
- Helix-turn-helix
- PFAM
- PF00250
- Desciption
- The fork head domain is a conserved DNA-binding domain (also known as a winged helix) of about 100 amino-acid residues. Drosophila melanogaster fork head protein is a transcription factor that promotes terminal rather than segmental development, contains neither homeodomains nor zinc-fingers characteristic of other transcription factors [1]. Instead, it contains a distinct type of DNA-binding region, containing around 100 amino acids, which has since been identified in a number of transcription factors (including D. melanogaster FD1-5, mammalian HNF-3, human HTLF, Saccharomyces cerevisiae HCM1, etc.). This is referred to as the fork head domain but is also known as a 'winged helix' [1, 2, 3]. The fork head domain binds B-DNA as a monomer [2], but shows no similarity to previously identified DNA-binding motifs. Although the domain is found in several different transcription factors, a common function is their involvement in early developmental decisions of cell fates during embryogenesis [3].
- Rederence
-
- The homeotic gene fork head encodes a nuclear protein and is expressed in the terminal regions of the Drosophila embryo. Weigel D, Jurgens G, Kuttner F, Seifert E, Jackle H. Cell 57, 645-58, (1989).
- Co-crystal structure of the HNF-3/fork head DNA-recognition motif resembles histone H5. Clark KL, Halay ED, Lai E, Burley SK. Nature 364, 412-20, (1993).
- Developmentally regulated Drosophila gene family encoding the fork head domain. Hacker U, Grossniklaus U, Gehring WJ, Jackle H. Proc. Natl. Acad. Sci. U.S.A. 89, 8754-8, (1992).
Statistic of Transcription Factors
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Transcription Factor Table
| Gene ID | Insect | Gene Name | Gene Symbol |
|---|---|---|---|
| iTF_00000119 | Abrostola tripartita | Atri004025.1 | foxc2 |
| iTF_00000120 | Abrostola tripartita | Atri020894.1 | slp2 |
| iTF_00000121 | Abrostola tripartita | Atri020893.1 | slp2 |
| iTF_00000122 | Abrostola tripartita | Atri013793.1 | FOXK2 |
| iTF_00000123 | Abrostola tripartita | Atri006348.1 | Foxd3 |
| iTF_00000124 | Abrostola tripartita | Atri004070.1 | FOXL2 |
| iTF_00000125 | Abrostola tripartita | Atri022176.1 | SGF1 |
| iTF_00000126 | Abrostola tripartita | Atri011561.1 | fd96Ca |
| iTF_00000127 | Abrostola tripartita | Atri003620.1 | Foxf2 |
| iTF_00000128 | Abrostola tripartita | Atri011559.1 | fd96Ca |
| iTF_00000129 | Abrostola tripartita | Atri011555.1 | fd96Ca |
| iTF_00000130 | Abrostola tripartita | Atri012373.1 | FOXJ3 |
| iTF_00000131 | Abrostola tripartita | Atri013755.1 | foxj1 |
| iTF_00000132 | Abrostola tripartita | Atri018655.1 | foxn4 |
| iTF_00000133 | Abrostola tripartita | Atri009133.1 | Foxd3 |
| iTF_00000134 | Abrostola tripartita | Atri008703.1 | FOXP1 |
| iTF_00000135 | Abrostola tripartita | Atri001349.1 | foxn3 |
| iTF_00000136 | Abrostola tripartita | Atri015028.1 | FOXL3 |
| iTF_00000137 | Abrostola tripartita | Atri016139.1 | foxo |