Basic Information

Insect
Nebria ingens
Gene Symbol
MBD-R2
Assembly
GCA_018344505.1
Location
JADQWA010001417.1:990-4805[+]

Transcription Factor Domain

TF Family
MBD
Domain
MBD domain
PFAM
PF01429
TF Group
Unclassified Structure
Description
The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 2 3.7e-18 1.7e-14 53.2 0.0 5 69 381 443 377 451 0.90
2 2 0.031 1.4e+02 2.2 0.0 42 75 979 1012 978 1014 0.88

Sequence Information

Coding Sequence
ATGGGGCGCAAATGTAATGTTTTGGATTGTCCGTCGGATTCAAGACGAATCGAAGATAATGGCGTTACGTTTCATAAAATGCCATTTCATCCAGATCTAAGACCGAAATGGCTAGAGCTATGCAGAGTTCCAGACGATCGGAAAACATGCAAAATTATTTACGTATGCTCGCGTCACTTTAGACGGACAGACTTTTGCAATTTCAAAGGTACAAAGTATATGCTGCGACAAGGTGCTTTGCCCTCAGTATTTCCATGGACGAAAATCATTACCAAATTGCCCCCGGCTTCGTCAAATAAATCTAAAACACCAGAGATGGACTGTGTTGAAATTAAAACAGAACATATTGATTCCGATGAGAATCAAGACAAACATTTAGAGGAGCAGGCCGATGACACGTTTGATGAAATGATTATTAAAAAAGAAATCAAAACCGAACCGACTGATGTTGTAGCGTCGTCCATAAACTTTTTACCGGGTACTCGAATCGAAGCGAATGATTTCAATGACAAATGGTACCCGGCGTCAATCGTCGAAGTTGACTACGAAGAGAATGAAGTTCTTGTAGAATTTGACAAACACTTAAACCGCGCAAATGAATGGATTCCCATGGATAGTTCGAGATTGCGTCCCTTGCAAGCTAGAGCGAACGTGGAATATTTTACTGTTGGTGAACGCGTAATGGCGACCTGGACGGAGTCTTGTAATAAATTTCCCGCCACCGTTCGATGTATACTAGAAGGCGATAGTTACGAAGTTTTATTCGACGACGGGTTTACAAAAATACTGAAACACCATAAAATGGCAAAAATAAAAGATAACACCGGGAAAGCTGCCGTACACATCGCCCCATTATTTGACCCGGTCGTTGGTTCGAAAGAAGAACGTCGAGAACGAAAACGGAAAATAAACGTAGCTGAGTTATTTGGAACTTCTAAGAAAAAAATCAAACACGAAGATCTGCAGATAAAACAAGAATCAATTGATATTGATGAGAAACTATCACAAGAAGAATATCCGACAAGTACAGGGTCATCCAGTCAGTACGAAGGCGAAGAATGGACGTGTCGCTGGTTAAATGGTGAACCAGTTGGGATTGAAGCAACTATAGATAGTAACGAAGGCCCCAAGAGATCCATTATAGTAGCCGATCATCGACTACCGCCGGGATGGGAAAAACATTTTGCACAACGGATATCCGGACACAATATAGGAAAATGGGATGCAATTTTAGTCAGTCCTGAAGGCAAGAAATTCCAATCGAAGAGTGCAATAAAAAACTGGCTTGAAGACAACAAAAGTGAATATCATCTAGATCAGTTTGATTTCTGTTTGCATTTGAAGCGTGCACGGAAATTAGGTCTGTATGAAGTACCAGCTAGAAACAAATCCAAGGGGACCCCAAAAATAGCTAGAGCAACATCAACGCCTAAAAACGAAGTAGAAGAACAAGATGAAAGTGGATTAAAGATAATAATGGAAAACGATTCGTACAAGTGCCCGATAGATGGATGCGGTAAAAATTTTCGTAAAGAAAACTTAGCACAGATGCATATCAAACATTATCATCCAGAATATTCAAAATTAATGGGCTCAACACCAAATGTGGCTGACTTAGCTTACGCTAGAACCGTCGGAGAACCAATCGATGACCATACACCAAAACTCAGACATCCATACCCCATAGACAGGCACATCAAGCTCGAATCAACTCCGAAACCAAAATCAACTACAGTCAAAGTGATTACCCCAAAAGTACCAGTGATCAAACAAGAAGACTTAGACCATAAAATCATAGAACCGCCGGTCAAAGATTCCGAGATCATAAAACTATTAAACAGCGAACCAAAATTGAAAACACTAGATGCAATCTTCGATCAACAAGAACTGGTATCATCGGAAAGTGTAACACCACAAGACAAGTATCCCGAAATTAAATTGAAAGACTTGCTGCACAAAGCTGAGCCGATTCCACTGAAAAAAGACGAACACAGACCAACCGGAATCAAAACGTTACTTCCGGTCATCCGACCGCCGATCGTAGATGATATTGAATTGGAGGAACTCGATGACCCAGTTCTTAAAGCACAAACTCAATTAAAAGACAAACCGAGACCGGGACGAAAGCGCCAAGGCTCAGAAAACGATCTTCTGAAACGCAGACGTCACTCATTCAAGTACGACACCGGTGATGATGTATCGGATTATAACGAAGGAGGCGCGGACAGCCACTCGCAAGAGTCTCTTAAGAGAACCGAACCGATATCAGCTTCCACGGTTGTCACAACGCAAGAGTCACCTCAGGTGATTATTGAAGGGGGTGAGGTAATCCGGTTGGTGCATATGCGCAGCGAAGAGATCATCAATTGCACTTGCGGTATAACGGAAGAAGATGGCTTGATGATTCAGTGCGAGTTGTGTCTGTGTTGGCAGCACGCGCACTGCAACAATATCCAACGCGAGAACCAAGTGCCAGATAAGTATGTGTGTAAAATCTGCAAGAATCCGTTGAGGATGCGCGCCTCCAAGAAGTATATCCACGATCAAGATTGGTTGAAACAAGGCGTGCTAGCTTCGGCGACCTACCACACCAAAGATGAACGACAACTCACGAATCGTTTTGAGAAATTACGGAAGACACATGAACTAAGTGGATGTTTGCTTGAACTAAACGAATATGTTCATAATTTGAACATTAAGTTAAATATTGCAGAAAATAAAGATCATCCGAAACTGTACTTGTGGGCAAAACCTTGGGACAAAACCGAACCAGAAGGATCTTTAAATCTAATCAAACAAGAAATAAAATCCGAAGACTTAACCGATGAACACAGTTACATGAGAGGCACCAGTACATTCGGCGACGTAGCCCTGAAAAGTATGCTCCAACCACCCGAGATCAAAATTGAACCGGATGTAAAATTAGACGATTCGAAAATAGAATCACAATCGGAACTGATCTCAATCCTTGAAGATAATGATGATGTTGTGAAACCAGAGTACCCAAAGATTGATCTGAACCAAATGATGATCAAAGAAGAACAGAAAGATCATGATGAACAATTGTTGGATGATGTTGATAATAATAAAGAAAATGTTCTGAACTCAATAACTAGTGGTATTTTGAGTGCTGGCTCGCTGGAGTTGGCTTTGAGTCAGTCTGATCTGGAGCGCTTATCCGCGCTGGCGCAGTTGAGTGTGGCGATGGCGCCACATGTACCTCAGCCCGAGGCGGCCATCGATTCGGCAGATTGCCGCATGAATTTATTGGATCATGTCGCGTACTATCAGAATTTAGTCGAAGAGCGATTGAATTCTATTGAATCAGAGATAAACGATCTAGAAGAAGCCGAACCGGATGTGGCTGCATCGGATGACAGCACAGAAAAAGACAACTATCCGAAAACCAAACAAACCTTACAGATGTTGATACGTGATTTGTCTACTATGCGCCAAATCGCTACTTTAACCCACTGA
Protein Sequence
MGRKCNVLDCPSDSRRIEDNGVTFHKMPFHPDLRPKWLELCRVPDDRKTCKIIYVCSRHFRRTDFCNFKGTKYMLRQGALPSVFPWTKIITKLPPASSNKSKTPEMDCVEIKTEHIDSDENQDKHLEEQADDTFDEMIIKKEIKTEPTDVVASSINFLPGTRIEANDFNDKWYPASIVEVDYEENEVLVEFDKHLNRANEWIPMDSSRLRPLQARANVEYFTVGERVMATWTESCNKFPATVRCILEGDSYEVLFDDGFTKILKHHKMAKIKDNTGKAAVHIAPLFDPVVGSKEERRERKRKINVAELFGTSKKKIKHEDLQIKQESIDIDEKLSQEEYPTSTGSSSQYEGEEWTCRWLNGEPVGIEATIDSNEGPKRSIIVADHRLPPGWEKHFAQRISGHNIGKWDAILVSPEGKKFQSKSAIKNWLEDNKSEYHLDQFDFCLHLKRARKLGLYEVPARNKSKGTPKIARATSTPKNEVEEQDESGLKIIMENDSYKCPIDGCGKNFRKENLAQMHIKHYHPEYSKLMGSTPNVADLAYARTVGEPIDDHTPKLRHPYPIDRHIKLESTPKPKSTTVKVITPKVPVIKQEDLDHKIIEPPVKDSEIIKLLNSEPKLKTLDAIFDQQELVSSESVTPQDKYPEIKLKDLLHKAEPIPLKKDEHRPTGIKTLLPVIRPPIVDDIELEELDDPVLKAQTQLKDKPRPGRKRQGSENDLLKRRRHSFKYDTGDDVSDYNEGGADSHSQESLKRTEPISASTVVTTQESPQVIIEGGEVIRLVHMRSEEIINCTCGITEEDGLMIQCELCLCWQHAHCNNIQRENQVPDKYVCKICKNPLRMRASKKYIHDQDWLKQGVLASATYHTKDERQLTNRFEKLRKTHELSGCLLELNEYVHNLNIKLNIAENKDHPKLYLWAKPWDKTEPEGSLNLIKQEIKSEDLTDEHSYMRGTSTFGDVALKSMLQPPEIKIEPDVKLDDSKIESQSELISILEDNDDVVKPEYPKIDLNQMMIKEEQKDHDEQLLDDVDNNKENVLNSITSGILSAGSLELALSQSDLERLSALAQLSVAMAPHVPQPEAAIDSADCRMNLLDHVAYYQNLVEERLNSIESEINDLEEAEPDVAASDDSTEKDNYPKTKQTLQMLIRDLSTMRQIATLTH

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00873044;
90% Identity
iTF_01039233;
80% Identity
iTF_01040182;