Basic Information

Gene Symbol
MBD-R2
Assembly
GCA_933228875.1
Location
CAKOGB010000048.1:219213-225077[+]

Transcription Factor Domain

TF Family
MBD
Domain
MBD domain
PFAM
PF01429
TF Group
Unclassified Structure
Description
The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 2 3.7e-18 1.1e-14 54.2 0.0 6 69 382 443 377 451 0.91
2 2 1.7 5.2e+03 -2.4 0.0 42 58 951 967 950 982 0.78

Sequence Information

Coding Sequence
ATGGGGCGCAAATGCAACGTATTGGATTGCCCGTCCGATTCCAGGCGCATTGAAGATAATGGCGTAACGTTTCATAAAATGCCGTTTCACCCAGATCTAAGGCCGAAATGGCTCGAATTGTGCCGCATTCCAGACGATCGTAAAACCTGCAAAATTATCTACGTATGCTCGCGTCATTTTCGCCGTACCGATTTTTGCAACTTTAAGGGCACTAAGTATATGCTGCGACAAGGTGCTTTGCCCTCAGTATTCCCTTGGACAAAAAGCATTACCAAATTGGTGCTCCCAGCTGCGTCCACTAAACCGACAACTGAGACACAGTCGGAAATGGATGATGACATTGAGATTAAAACGGAACCGATTGAAGACGCGAGCAAAGATTTAGAAGAACGGACCGATGACACATTTGATGAGATGATTAAAAAAGAAATCAAAACTGAGCCGAATGATGCGGTTGAGGCAGTGAATCAGATTAATTTTATGTCGGGGACGCGTATCGAAGCGAACGATTTTAATGATAAATGGTATCCGGCGTCAATTGTTGAAGTTGATTATGAAGAGAATGAGGTTCTGGTCGAATTTGATAAACATTTGAATCGTGCGAATGAATGGATTCCAATGGACAGTTCTAGATTGCGGCCATTTCAGGCGCGGGCCAACGTTGAGTACTTTAGCGTTGGTGAACGCGTGCTGGCGACATGGACGGAAACTTGCAACAAATTTCCGGCCACCGTTCGCTGCATCCTAGAGGGCGATAGCTACGAAGTTTTATTTGATGACGGCTTCACAAAAGTACTTAAACATCATAAAATGGCTAAAGTTAAAGATGCATTAAATAAACCTGCTGTGCACATCGCCCCATTATTTGATCCTGTTGTCGGCTCGAAAGAGGAACGCAGAGAACGCAAACGGAAAATAAATGTAGCGGAACTATTTGGGGTGTCCAAGAAAAAAATAAAGCAAGATGACATCAAATTGGAAGGGAATGATGAAGAGAAATTATCACAAGAAGAATATCCGACAAGTACTGGATCTTTAAGCCAGTACGAAGGTGAAGAATGGACTTGTCGCTGGCTGAACGGCGAACCAGTCGGGATTGAATCCACTATTGACAGTAACGAGGGCAGCAAAAAGTCCATCATTGTCGCAGACCATCGCCTACCTCCTGGATGGGAGAAACATTTTGCGCAACGTGTATCCGGCAACAACATCGGCAAATGGGACGCAATATTAGTGAATCCCAATGGTAAAAGATTCCATTCAAAGAACTCTATAAAAAACTGGCTAGAAGACAACAACAGTGAATACCATATAGATCAATTTGATTTTTGCTTACATTTAAATCGCGCACGGAAATTAGGCTTATATGAATTACCGACGAAAATGCCGAATGAGGGCGGATTGAAAATAATAATGGAGAATGATTCCTACAAATGTCCGATTGACGGTTGCGGTAAAAATTTCCGTAAAGAAAACTTGGCCCAAATGCATATCAAACATTATCACCCTGAGTATTCAAAGTTGATGGGCTCAACACCAAATGTGGCCGATTTAGCGTATGCGCGAACCGTCGGTGAATCAATCGACGATCATACACCAAAAATGAGACATCCACTTCCCATCAAACTGGAATCAACTCCAAAACCAAAAACAAACACACTGAAAGTTATAACACCAAAAATGCCGTTCATCAAACAAGAGGACATTGATCAAAAAATAACTGAAACACCAAGACCGCCGGGTAAAGATACTGAAATAATAAAACTACTAAACAGTGAACCAAAATTGAAAACATTAGACGCGATCTTCGATCAGCAAGATTTGGTTTCAACGAAAGTTGCTACACCGCAGGACAAGTACCCTGAGATCAAGTTGAAAGATTTATTGCACAAATCCGAACCAATTCCACAGAAAAAGGACGACCACAGACCGACCGGGATCAAAACATTACTACCAGTGATTCGTCCACCGATCATCGATGAAATCAAATCGGAGGAAATCGATATGGAGCCGCCAGCACAATTTAAAATACATGATAAACCTCGACCAGGACGCAAACGCCAAGGTTCAGAGAACCAGGATTATTTTAAACGTAGGCGGCAATCTGTTAAGTATGAGATGGATGAGGATTATTACGAGGGTGGCGCCGATTCGCTCGATTCCTTCAAGCAAGCTGAACCGATACCAGCGTCAACAGTTGTAACAACGCAAGAATCACCCGAAGTGATTATTGAAGGTGGTGAGGTGATTCGGTTGGTGCATATGCGCAGCGAAGAGATTATCAATTGCACTTGCGGCATTACCGAAGAAGATGGGTTGATGATTCAGTGTGAATTGTGTCTGTGCTGGCAGCACGCTCATTGCAACAACATCCAACGCGAAAACCAGGTGCCCGATAAGTACGTGTGTAAAATCTGCAAGAATCCGCTGAGGATGCGCGCCTCTAAGAAGTACATCCACGACCAAGACTGGTTGAAACAAGGCACTTTGGCGTCGGCAAGCTTTCACACCAAAGATGAGCAACAATTCGCGACGCGGTTCGAGAAATTACGGAAGACACACGAGCTGAGCGGATGTTTGCTTGAACTAAACGAATATGTTCACAATTTGCGCATTAAATTAAATATTGCAGAGAATAAAGATCATCCGAAACTGTATCTATGGGCGAAACCATGGGACAAAACCCAACCAGAAGGAACTTTAAATCTAATCAAGCAAGAAATTAAAGTCGAAGATGCCGCAGAGCCCAGTTACATGGAAGGTGGCAGTACTTTTGGCGATGTAGCACTGAAAAGTATGCTTCAGCCACCGGAGGTTAAAATTGAACCGGAGCAAAAGTTAGTTGATTCAAAAATCGAATCACAATCTGAATTGATATCAATCCTTGAAGACACGGATGATGATGAAGTGAAATCTGATTATCCAAAGATCGACTTGAACCAAATGATGATAAAAGAGGAACAAAAAGACAGTATTAATGATGAACTATTGGATGATGAGGGTAATAAGGAAAACGTAATGAATTCGGTAACCACTGGTATTTTGAGCGCTGGTTCTTTGGAGCTGGCTCTAAGTCAGTCGGATTTGGAGCGTTTGTCTACGTTGGCGCAGTTAAGTGTGGCGATGGCGCCGCAACCGGAAGCGCCCATCGATTCAGCTGATTGCCGCATGAATTTATTGGATCACGTTGCTTATTATCAAAATTTAGTCGAGGAGCGTTTGAACAGTATTGAATCAGAAATAAATGATTTAGAGGAAGCTGAACCGGATATCGCTGCATCCAATGACAACGTAGAGAACTATCCGAAAACCAAACAGACTTTACAAATGTTGATTCGCGATTTATCGACTATGCGCCAAATCGCTACTTTAACCCACTAA
Protein Sequence
MGRKCNVLDCPSDSRRIEDNGVTFHKMPFHPDLRPKWLELCRIPDDRKTCKIIYVCSRHFRRTDFCNFKGTKYMLRQGALPSVFPWTKSITKLVLPAASTKPTTETQSEMDDDIEIKTEPIEDASKDLEERTDDTFDEMIKKEIKTEPNDAVEAVNQINFMSGTRIEANDFNDKWYPASIVEVDYEENEVLVEFDKHLNRANEWIPMDSSRLRPFQARANVEYFSVGERVLATWTETCNKFPATVRCILEGDSYEVLFDDGFTKVLKHHKMAKVKDALNKPAVHIAPLFDPVVGSKEERRERKRKINVAELFGVSKKKIKQDDIKLEGNDEEKLSQEEYPTSTGSLSQYEGEEWTCRWLNGEPVGIESTIDSNEGSKKSIIVADHRLPPGWEKHFAQRVSGNNIGKWDAILVNPNGKRFHSKNSIKNWLEDNNSEYHIDQFDFCLHLNRARKLGLYELPTKMPNEGGLKIIMENDSYKCPIDGCGKNFRKENLAQMHIKHYHPEYSKLMGSTPNVADLAYARTVGESIDDHTPKMRHPLPIKLESTPKPKTNTLKVITPKMPFIKQEDIDQKITETPRPPGKDTEIIKLLNSEPKLKTLDAIFDQQDLVSTKVATPQDKYPEIKLKDLLHKSEPIPQKKDDHRPTGIKTLLPVIRPPIIDEIKSEEIDMEPPAQFKIHDKPRPGRKRQGSENQDYFKRRRQSVKYEMDEDYYEGGADSLDSFKQAEPIPASTVVTTQESPEVIIEGGEVIRLVHMRSEEIINCTCGITEEDGLMIQCELCLCWQHAHCNNIQRENQVPDKYVCKICKNPLRMRASKKYIHDQDWLKQGTLASASFHTKDEQQFATRFEKLRKTHELSGCLLELNEYVHNLRIKLNIAENKDHPKLYLWAKPWDKTQPEGTLNLIKQEIKVEDAAEPSYMEGGSTFGDVALKSMLQPPEVKIEPEQKLVDSKIESQSELISILEDTDDDEVKSDYPKIDLNQMMIKEEQKDSINDELLDDEGNKENVMNSVTTGILSAGSLELALSQSDLERLSTLAQLSVAMAPQPEAPIDSADCRMNLLDHVAYYQNLVEERLNSIESEINDLEEAEPDIAASNDNVENYPKTKQTLQMLIRDLSTMRQIATLTH

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2