Nbre012698.1
Basic Information
- Insect
- Nebria brevicollis
- Gene Symbol
- MBD-R2
- Assembly
- GCA_944739395.1
- Location
- CALYJC010000237.1:133212-137002[+]
Transcription Factor Domain
- TF Family
- MBD
- Domain
- MBD domain
- PFAM
- PF01429
- TF Group
- Unclassified Structure
- Description
- The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 2 4.1e-19 1.7e-15 57.3 0.0 5 69 380 442 376 450 0.90 2 2 0.36 1.5e+03 -0.3 0.0 42 64 978 999 977 1012 0.73
Sequence Information
- Coding Sequence
- ATGGGGCGCAAATGCAATGTTTTGGATTGTCCATCGGATTCCAGACGCATCGAAGATAATGGTGTTACGTTTCATAAAATGCCATTTCATCCAGATTTAAGACCGAAATGGCTCGAGTTATGCAGAGTCCCAGACGATCGCAAAACatgcaaaattatatatgtatgctcGCGTCATTTCAGACGTACAGACTTTTGCAATTTCAAAGGTACGAAGTATATGCTGCGACAGGGTGCTTTGCCCTCAGTATTTCCATGGACGAAAATCATTACCAAATTGCCTCCGCCTTCATCCAGTAAATCGAAAACACCAGAAATGGACAGCGTTGACATTAAAACAGAGCCTATTGATTTCGATGAGAAACATGACACACATTTAGAAGCGCAAGCAGACGACACTTTCGATGAAATggttattaaaaaagaaatcaAAACCGAGCCGATTGATGTGCCGTCGTCTATAAACTTCCTACCAGGCACTCGCATCGAAGCGAATGATTTCAATGATAAATGGTACCCGGCGTCAATCGTCGAAGTTGACTACGAAGAGAACGAAGTTCTTGTCGAATTCGACAAACACTTGAACCGCGCGAACGAATGGATTCCCATGGATAGTTCGAGATTGCGTCCCTTTCAAGCTAGAGCTAACGTGGAATATTTTAGCGTTGGCGAACGAGTAATGGCAACCTGGACGGAATCTTGTAATAAATTCCCCGCCACCGTTCGATGTATTCTAGAAGGTGACAGTTACGAAGTTTTATTCGATGAcggttttacaaaaatacttAAACACCATAAAATGGCGAAAATCAAAGACAGTACCGGAAAAACGCCCGTGCACATCGCCCCATTATTTGACCCAGTCGTTGGTTCGAAAGAAGAACGCCGAGAACGAAAACGTAAAATAAACGTGGCTGAGTTATTTGGCGTTTCTaagaaaaaaatcaaacacgAAGATCTGCAGTTGAAACAAGAAACAATTGATGTCGAAGAGAAACTATCACAAGAAGAATATCCGACAAGTACAGGGTCATCCAGTCAGTACGAAGGCGAAGAATGGACGTGTCGCTGGTTAAACGGCGAGCCGGTAGGAATTGAATCAAGCATAGAGAGTAATGAAGGCACCAAGAGATCCATCATAGTCGCCGATCATCGATTGCCGCCAGGGTGGGAGAAACATTTTGCACAACGGATATCCGGACAGAACATGGGGAAATGGGACGCAATTTTAGTCAGTCCTGAAGGCaaaaaatttcaatcaaagagttcaattaaaaattggtTAGAAGACAACAAAAGTGAATATCATCTAGATCAGTTTGATTTCTGTTTGCATTTGAAACGTGCACGGAAATTAGGTCTGTACGAATTACCAGCTAGAATCAAATCAAAGGGAACTCCAAAAATCGCTAGAGCACCATTAACACCTAAAATCGAAATTGAAGAACAGGATGaaagtggattaaaaataatattggaaAACGATTCATATAAATGTCCGATAGATGGATGCGGTAAAAATTTCCGTAAAGAAAACTTAGCCCAGATGCATATCAAACATTACCATCCAGAATACTCAAAATTAATGGGCTCAACACCAAATGTTGCTGACCTGGCGTACGCAAGAACCGTCGGTGAACCAATCGATGATCATACACCAAAACTCCGACATCCATATCCAGTAGACAGACACATCAAGCTCGAGTCAACCCCGAAACCAAAATCAAATACAGTCAAAGTCATTACCCCAAAAGTACCAATAATCAAACCAGAAGACGAAGACCTTAAAATCATGGAACCGCCAGGCAAAGATTCCGAGATCATCAAACTACTAAACAGCGAACCAAAATTGAAAACACTCGATGCAATCTTCGATCAACAAGAACTGGTATCATCTGAAACCGTAACACCACAAGACAAATATCccgaaattaaattgaaagactTGCTGCACAAGGCTGAACCGATACCCCTGAAAAAAGATGAACACAGAGCAACGGGAATTAAAACGTTACTTCCAGTCATCCGGCCTCCGATCGTAGATGATATTGAATCAGAGGAACTCGATGAGACAGTCCTTAAAGCACAAACTCAATCAAAAGACAAACTGAGACCGGGACGAAAGCGTCAAGGTTCAGAAAACGATCTCCTGAAACGCAGACGACATTCATTCAAGTACGACACCGGTGAGGATGTATCCGATTATTACGAAGGAGGCGCGGACAGTCACTCGCAAGAATCTCTTAAAAGAACTGAACCGATATCAGCTGCCACGGTTGTAACAACGCAAGAGTCACCTCAGGTGATTATTGAAGGTGGTGAAGTTATTCGGTTGGTACATATGCGCAGCGAAGAGATTATTAATTGCACTTGTGGCATCACCGAAGAAGATGGTTTGATGATTCAATGCGAGTTGTGTCTGTGTTGGCAGCACGCGCACTGCAACAATATACAACGTGAGAACCAAGTGCCAGACAAGTACGTGTGTAAAATCTGCAAGAATCCGTTAAGGATGCGCGCCTCCAAGAAGTATAGCCACGACCAAGACTGGCTGAAACAAGGCGTGCTGGCTTCGGCGACCTACCACACTAAAGATGAACGACAATTCGCGAATCGGTTTGAGAAATTACGGAAGACACATGAATTAAGTGGTTGTTTACTTGAACTAAACGAATATGTTCATAACTTAAACATTAAGTTAAATGTTGCTgaaaaTAAAGACCATCCGAAACTGTACCTGTGGGCAAAACCTTGGGACAAAACTGAACCAGAAGGATCTTTAAATCTAATCaaacaagaaataaaatcTGAAGACTTATCCGATGAACATAGTTACATAAAAGGCACCAGCACATTCGGCGACGTAGCGCTAAAAAGTATGCTACAACCACCCGAGATCAAAAACGAACCGGATATAAAATTGGATGACTCGAAAATAGAATCACAATCAGAACTGATCTCAATCCTTGAAGATAATGATGATGTGAAACAAGAGTACCCTAAGATTGATCTGAATCAAATGATGGTTAAAGAAGAACGGAAAGATAACGAGGAGCAATTGTTGGACGATGTCGAtgataataaagaaaatgttCTAAATTCAATCACCAGTGGTATTTTGAGTGCTGGATCGCTCGAGTTGGCTTTGAGTCAATCCGACCTGGAGCGCTTGTCAGCGCTGGCGCAGTTGAGTGTGGCGATGGCTCCACTTGAACCACAACCCGAGGCGGCCATCGATTCGGCAGATTGTCGCATGAATTTATTGGATCATGTTGCGTACTATCAGAATTTAGTCGAAGAGCGATTAAATTCTATTGAATCCGAGATTAACGATTTGGAAGAAGCTGAGCCGGAAGTGGCTGCAACGGATGACAACACAGATAAAGACAATTATCCGAAAACGAAACAAACCTTACAGATGCTAATACGTGATTTGTCGACTATGCGCCAAATCGCTACTTTAACTCACTGA
- Protein Sequence
- MGRKCNVLDCPSDSRRIEDNGVTFHKMPFHPDLRPKWLELCRVPDDRKTCKIIYVCSRHFRRTDFCNFKGTKYMLRQGALPSVFPWTKIITKLPPPSSSKSKTPEMDSVDIKTEPIDFDEKHDTHLEAQADDTFDEMVIKKEIKTEPIDVPSSINFLPGTRIEANDFNDKWYPASIVEVDYEENEVLVEFDKHLNRANEWIPMDSSRLRPFQARANVEYFSVGERVMATWTESCNKFPATVRCILEGDSYEVLFDDGFTKILKHHKMAKIKDSTGKTPVHIAPLFDPVVGSKEERRERKRKINVAELFGVSKKKIKHEDLQLKQETIDVEEKLSQEEYPTSTGSSSQYEGEEWTCRWLNGEPVGIESSIESNEGTKRSIIVADHRLPPGWEKHFAQRISGQNMGKWDAILVSPEGKKFQSKSSIKNWLEDNKSEYHLDQFDFCLHLKRARKLGLYELPARIKSKGTPKIARAPLTPKIEIEEQDESGLKIILENDSYKCPIDGCGKNFRKENLAQMHIKHYHPEYSKLMGSTPNVADLAYARTVGEPIDDHTPKLRHPYPVDRHIKLESTPKPKSNTVKVITPKVPIIKPEDEDLKIMEPPGKDSEIIKLLNSEPKLKTLDAIFDQQELVSSETVTPQDKYPEIKLKDLLHKAEPIPLKKDEHRATGIKTLLPVIRPPIVDDIESEELDETVLKAQTQSKDKLRPGRKRQGSENDLLKRRRHSFKYDTGEDVSDYYEGGADSHSQESLKRTEPISAATVVTTQESPQVIIEGGEVIRLVHMRSEEIINCTCGITEEDGLMIQCELCLCWQHAHCNNIQRENQVPDKYVCKICKNPLRMRASKKYSHDQDWLKQGVLASATYHTKDERQFANRFEKLRKTHELSGCLLELNEYVHNLNIKLNVAENKDHPKLYLWAKPWDKTEPEGSLNLIKQEIKSEDLSDEHSYIKGTSTFGDVALKSMLQPPEIKNEPDIKLDDSKIESQSELISILEDNDDVKQEYPKIDLNQMMVKEERKDNEEQLLDDVDDNKENVLNSITSGILSAGSLELALSQSDLERLSALAQLSVAMAPLEPQPEAAIDSADCRMNLLDHVAYYQNLVEERLNSIESEINDLEEAEPEVAATDDNTDKDNYPKTKQTLQMLIRDLSTMRQIATLTH
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- iTF_00873044;
- 90% Identity
- iTF_01040873; iTF_01039293; iTF_01040927; iTF_01040124; iTF_01040182;
- 80% Identity
- iTF_01039293;