Basic Information

Gene Symbol
MBD3
Assembly
GCA_030264115.1
Location
JAEMON010000009.1:4480721-4494124[+]

Transcription Factor Domain

TF Family
MBD
Domain
MBD domain
PFAM
PF01429
TF Group
Unclassified Structure
Description
The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 2 1.2e-21 6.2e-18 65.0 0.0 5 72 7 69 3 73 0.92
2 2 0.0003 1.6 9.2 0.1 28 73 89 145 76 148 0.81

Sequence Information

Coding Sequence
ATGTCAGTAGAGAAAAGGAGATTCGAATGCACAGCTCTACCGAAAGGCTGGCAAAGAGAAGAGGTAGTTCGAAAAACCGGTCTCTCAGCTGGAAAAGTTGATGTGTGTTATTACAGTCCGGAAGGCCAGAAATTTGAGAGTAAGCCCCAGCTAGTGCGTGCTATGAGTGATACAGTTGATCTGACAACATTTGATTTCTCGACAGGGAAATGTAATAGCCTCCTTGCTCGTAggcacaaaaaacctcgaactAGTCAATATGATTACAGcCGTGGTGTAAGAAACGATGCTTCTCTGGTCCCCCCTATCAGGCAAACTGCATCTATATTTAAGCAGCCTGTTACGGTTTTTAAGTCTCAGGAAGGAAAAGTAAAAACGGATTTCAAACATGGGCCACAAGAAAAGCCAAAGCAGTTGTTCTGGGAGAAACGCCTGGAAGGTCTCCACGCTAGTGACATCTTGGGTAACGAGCTGAAGGGGTTAGGACTCCCCAAATCCCTGCGTCCAGTTGGCCCACACGTCACAGACGAAACATTGTTGCAATCCGTAGCGACTGCTCTCCACGTACTTGGACAGCCCATCACTGGGCAGACTGGGTTGAAGGACAACCTTGAAAAAAATCCCGGAGTTTTCATCAATACAGACCAGCCTTTGGTTCAGGCCGTGGCTATAAGCGAAGATGACATCAAACGCCAAGAAGAGAGAGTTCTCGCAGCCAGACGGAAGTTGCAGGAAGCGTTGAAAGAACTGGAAGGGTAA
Protein Sequence
MSVEKRRFECTALPKGWQREEVVRKTGLSAGKVDVCYYSPEGQKFESKPQLVRAMSDTVDLTTFDFSTGKCNSLLARRHKKPRTSQYDYSRGVRNDASLVPPIRQTASIFKQPVTVFKSQEGKVKTDFKHGPQEKPKQLFWEKRLEGLHASDILGNELKGLGLPKSLRPVGPHVTDETLLQSVATALHVLGQPITGQTGLKDNLEKNPGVFINTDQPLVQAVAISEDDIKRQEERVLAARRKLQEALKELEG

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2