Basic Information

Gene Symbol
MBD3
Assembly
GCA_954871275.1
Location
OX940977.1:53655331-53665435[-]

Transcription Factor Domain

TF Family
MBD
Domain
MBD domain
PFAM
PF01429
TF Group
Unclassified Structure
Description
The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 2 4.1e-21 4.7e-17 63.5 0.0 5 73 7 70 3 73 0.92
2 2 0.00084 9.7 8.0 0.1 28 73 89 145 77 148 0.80

Sequence Information

Coding Sequence
ATGTCAGTTGAAAAAAGGAGATTCGAATGCACAGCTCTGCCGAAAGGTTGGCAAAGGGAAGAAGTAGTTCGAAAAACCGGCCTCTCAGCTGGAAAAGTTGATGTCTGCTACTACAGCCCGGATGGCCAGAAATTTGACAGTAAGCCCCAACTAGTGCGTGCTATGAGTGATACAGTTGATCTGACCACATTTGATTTCTCTACAGGGAAATCTAATAGCCTCCTAGCCCGTAGGCACAAAAAACCTCGAACTAGTCAATATGATTACAGTCGTGGTGTACGAAACGATGCGTCTCTGGTTCCCCCAATTAGACAAACTGCGTCCATATTCAAACAGCCTGTAACCGTCTATAAGTCTCAAGAAGGAAAAGTGAAAACAGATTTCAAACATGGACCCCAAGAGAAGCCCAAACAGTTGTTCTGGGAAAAGCGCCTTGAAGGCCTCCACGCCAGTGACATCTTGGGCAATGAGCTGAAAGGACTCGGCCTCCCCAAGTCCCTGCGGCCAGTCGGCCCACATGTCTCTGACGAAACACTCCTGCAGTCCGTAGCTACTGCATTACACGTACTCGGGCAGCCCATTACTGGGCAGACGGGGTTGAAAGACAACCTAGAGAAAAACCCTGGAGTTTTCATCAACACAGAACAGCCTTTGGTTCAGGCCGTTGCCGTAAGCGAAGACGACATCAAACGCCAAGAAGAGAGAGTCCTGATAGCCAGGCGGAAGTTGCAGGAAGCTTTGAAAGAACTGGAAGGGTAA
Protein Sequence
MSVEKRRFECTALPKGWQREEVVRKTGLSAGKVDVCYYSPDGQKFDSKPQLVRAMSDTVDLTTFDFSTGKSNSLLARRHKKPRTSQYDYSRGVRNDASLVPPIRQTASIFKQPVTVYKSQEGKVKTDFKHGPQEKPKQLFWEKRLEGLHASDILGNELKGLGLPKSLRPVGPHVSDETLLQSVATALHVLGQPITGQTGLKDNLEKNPGVFINTEQPLVQAVAVSEDDIKRQEERVLIARRKLQEALKELEG

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00930337;
90% Identity
iTF_00930337;
80% Identity
-