Basic Information

Gene Symbol
MBD3
Assembly
GCA_037159825.1
Location
JASJUZ010000040.1:422261-429447[+]

Transcription Factor Domain

TF Family
MBD
Domain
MBD domain
PFAM
PF01429
TF Group
Unclassified Structure
Description
The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 2 2e-21 5.9e-18 64.6 0.0 3 72 5 69 3 73 0.91
2 2 0.0011 3.2 7.8 0.1 28 73 87 145 76 148 0.80

Sequence Information

Coding Sequence
ATGACTTCCGATAGACGTAGGTTCGACTGCACAGCTTTACCGAAAGGATGGCAAAGGGAAGAGGTCGTCCGTAAAACCGGCCTGTCAGCTGGAAAAGTCGACGTTTGTTACTACAGCCCGGATGGCCAGAGGTTTGAGAGTAAACCGCAGCTAGTTCGAGCAATGAGTGATTCGGTCGATCTGACCACTTTTGATTTCTCAACTGGCAAATGTAATAGTCTCCTTGCTCGTAGACATAAAAAGCCTCGAACTAGTCACTATGATTACAGtcGTGGTGTTCGCAATGATGCTTCGTTGGTTCCCCCTATTCGACAAACTGCATCCATTTTTAAACAGCCAGTTACAGTCTACAGGTCTCAGGAGGGGAAAATCAAAACTGACGTCAAACACGGTCCTCAAGAAAAACCGAAACAGTTGTTCTGGGAAAAACGGCTAGAAGGTCTCCATGCTAGCGATATGATGGGCAATGAACTGGGAGGCATGGGGCTGCCGAAACCATTGAAACCTGTCGGTCCAAATATTAGAGATGAGACGCTTCTTCAATCAGTCGCAACAGCTCTCCACGTGCTTGGAAAACCAATTACTGGTCAAACAGGTTTAAAAGACAATTTGGAAAAGAACCCCGGCGTATACATTAACTCAGAGCAACCCTTAGTTCAGGCTGTGGCCATCAGCGACGAAGACATCAAGCGGCAGGAAGAGAGAGTTCACTTGGCCAGGCGGAGACTGCAGGAAGCGCTTAATGAATTGGATGATTGA
Protein Sequence
MTSDRRRFDCTALPKGWQREEVVRKTGLSAGKVDVCYYSPDGQRFESKPQLVRAMSDSVDLTTFDFSTGKCNSLLARRHKKPRTSHYDYSRGVRNDASLVPPIRQTASIFKQPVTVYRSQEGKIKTDVKHGPQEKPKQLFWEKRLEGLHASDMMGNELGGMGLPKPLKPVGPNIRDETLLQSVATALHVLGKPITGQTGLKDNLEKNPGVYINSEQPLVQAVAISDEDIKRQEERVHLARRRLQEALNELDD

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00930337;
90% Identity
-
80% Identity
-