Basic Information

Transcription Factor Domain

TF Family: zf-GAGA
Domain: zf-GAGA domain
PFAM: PF09237
TF Group: Zinc-Coordinating Group
Description: Members of this family bind to a 5'-GAGAG-3' DNA consensus binding site, and contain a Cys2-His2 zinc finger core as well as an N-terminal extension containing two highly basic regions. The zinc finger core binds in the DNA major groove and recognises the first three GAG bases of the consensus in a manner similar to that seen in other classical zinc finger-DNA complexes. The second basic region forms a helix that interacts in the major groove recognising the last G of the consensus, while the first basic region wraps around the DNA in the minor groove and recognises the A in the fourth position of the consensus sequence [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 5 0.018 1.5e+02 3.8 0.1 16 43 107 135 100 140 0.68

2 5 0.0076 65 5.0 0.0 22 45 143 166 139 173 0.85

3 5 0.0016 14 7.1 0.1 22 45 171 194 165 197 0.88

4 5 5.6e-05 0.48 11.8 0.1 21 52 198 229 196 229 0.88

5 5 0.0015 13 7.2 0.0 21 48 226 253 222 255 0.90

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	5	0.018	1.5e+02	3.8	0.1	16	43	107	135	100	140	0.68
2	5	0.0076	65	5.0	0.0	22	45	143	166	139	173	0.85
3	5	0.0016	14	7.1	0.1	22	45	171	194	165	197	0.88
4	5	5.6e-05	0.48	11.8	0.1	21	52	198	229	196	229	0.88
5	5	0.0015	13	7.2	0.0	21	48	226	253	222	255	0.90

Coding Sequence: ATGGAAAATGACGACCAGGATGAAGTTTTTCGATCACACTTAGAACCTGATGTTATAATCGATGATTCGgaAGACTCCTACTACGATGATGATGTCATCGATACAAGTCACATACAAGCACAAATTGGTCCCGAGGTATCTCTTATACCAGTCAAAAAGAatccaatcaaaattaaaatgtttggtaAGCTGTCATGCAAGGATAAATCTAATTTGGAAGtgtacaaaattcaaaaaatagtgCAACAAAGATCTCCACGTCAAAATGTAAGACTGATATCGAAAGAAGAAGAGATACAAGCGGAAACCGaagttataaattcaaaacGAAAATCACTTCCATTAGAAAAGTGTCCTATATGTAAGAAATTTTTTCGCCGCATGAAAACTCATTTACAAAAACACGAAAATGTCACTCGAGATCCAAATGATCCATTAACATGCCAATTTTGTAAGAAAGTTTTTAATACTGGCAGTAATTTAAGTATACACATGCGTACACATACAGGTGACAAACCATATATATGTGAGATATGTACGAAAGGATTTGCACAATCATGTAATTTGATTAACCATATGCGTATTCACACAGGTGAGAGGCCTTTTAAATGTCCACATTGTGATCGTGCTTTTACACAATCAGGCAACCTAAATAATCACGTAAGATTACATACCGATGAGAAACCATTTAAATGTCACTTTTGTGAAAAAGCATTTACTCAATCAGGCAATCTCAATTCTCACATTCGAAACAAtcacaaaattacaaacataGAAAATGAATTGAGCGATATCGAACTGGTTCAGTAG
Protein Sequence: MENDDQDEVFRSHLEPDVIIDDSEDSYYDDDVIDTSHIQAQIGPEVSLIPVKKNPIKIKMFGKLSCKDKSNLEVYKIQKIVQQRSPRQNVRLISKEEEIQAETEVINSKRKSLPLEKCPICKKFFRRMKTHLQKHENVTRDPNDPLTCQFCKKVFNTGSNLSIHMRTHTGDKPYICEICTKGFAQSCNLINHMRIHTGERPFKCPHCDRAFTQSGNLNNHVRLHTDEKPFKCHFCEKAFTQSGNLNSHIRNNHKITNIENELSDIELVQ

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00273092;
90% Identity: iTF_00270438; iTF_01293190; iTF_00270697; iTF_00271850; iTF_00272106; iTF_01294347; iTF_00928079; iTF_01294617; iTF_01292796; iTF_00273275; iTF_00273092;
80% Identity: iTF_00928079;