Basic Information

Transcription Factor Domain

TF Family: zf-GAGA
Domain: zf-GAGA domain
PFAM: PF09237
TF Group: Zinc-Coordinating Group
Description: Members of this family bind to a 5'-GAGAG-3' DNA consensus binding site, and contain a Cys2-His2 zinc finger core as well as an N-terminal extension containing two highly basic regions. The zinc finger core binds in the DNA major groove and recognises the first three GAG bases of the consensus in a manner similar to that seen in other classical zinc finger-DNA complexes. The second basic region forms a helix that interacts in the major groove recognising the last G of the consensus, while the first basic region wraps around the DNA in the minor groove and recognises the A in the fourth position of the consensus sequence [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 4 0.002 42 7.1 0.1 15 47 109 142 96 147 0.77

2 4 0.00059 12 8.8 0.0 21 47 144 170 140 175 0.86

3 4 0.0006 12 8.8 0.1 21 45 172 196 167 201 0.87

4 4 0.00098 20 8.1 0.0 21 45 201 225 195 232 0.87

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	4	0.002	42	7.1	0.1	15	47	109	142	96	147	0.77
2	4	0.00059	12	8.8	0.0	21	47	144	170	140	175	0.86
3	4	0.0006	12	8.8	0.1	21	45	172	196	167	201	0.87
4	4	0.00098	20	8.1	0.0	21	45	201	225	195	232	0.87

Coding Sequence: ATGAGGAGAGGAGATTATTGGATTCTAGTGCGTGCAGATGGACCCTCCCCTTTGTGGGGAGAACTCCAGCAGGGAGGTCCCGGCCGAGGGGCAACAAGGGCACCATTATGGGGTGAAGCAGCCACGCAGCATGTTCGTGAATTGTGGCAGGAATTCTTGCTGCCACTTAGTCATGCCCCTCCACCCCCTAGTGCTACACCTGTTACTACTGCTGTACCTACCACCTCTCCCAGCAGCCCTACAGATTTGGACGAGCAGCAGTCTTGTGTCATGTGCCTCAAGGGCACACCTCCCCCTACGAACAGTACACCCTCCCCTTCCAGCACTACTTCACGCTCACATGCAGGAGATCGCCCATTTAGTTGCGATGTATGTGGCAAAGGCTTTACTCAGGCGGCACATCTGACGAGGCACACCAGAGTGCATACAGGGGAGAAGCCATTTTCGTGCGGtgtgtgtggtaaatgtttctcACAGTCTGGAGATTTGACTCGTCATGCTCGCGTACATACTGGCGAGAAGCCATACTCATGTTCCGTGTGCCTGAAACGATTCTCCCAGTCTGGTGACCTCAGCCGACATACTCGACGTGCCCACCCTGGTGAGAATCCCTTTTCTTGTGCAGTGTGCCTCAAGAGTTTCTCACAGTCAGGAGGTCTGACTCGACATACACGGGTTCATGCAACTACTCCTTCACCTACACAGTCCTCAAGGACATCACCAAGTGAGCAAGCAAGACAGTTCTTCCCTGACGTAATGTCACCACCCTGA
Protein Sequence: MRRGDYWILVRADGPSPLWGELQQGGPGRGATRAPLWGEAATQHVRELWQEFLLPLSHAPPPPSATPVTTAVPTTSPSSPTDLDEQQSCVMCLKGTPPPTNSTPSPSSTTSRSHAGDRPFSCDVCGKGFTQAAHLTRHTRVHTGEKPFSCGVCGKCFSQSGDLTRHARVHTGEKPYSCSVCLKRFSQSGDLSRHTRRAHPGENPFSCAVCLKSFSQSGGLTRHTRVHATTPSPTQSSRTSPSEQARQFFPDVMSPP

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_01411149; iTF_00435056; iTF_00955984; iTF_00821267; iTF_01411000; iTF_00435195; iTF_00955840;
90% Identity: iTF_00955840;
80% Identity: iTF_00821267;