Basic Information

Gene Symbol
e2f7
Assembly
GCA_945859575.2
Location
OX243832.1:19190756-19191946[+]

Transcription Factor Domain

TF Family
E2F
Domain
E2F_TDP domain
PFAM
PF02319
TF Group
Helix-turn-helix
Description
This family contains the transcription factor E2F and its dimerisation partners TDP1 and TDP2, which stimulate E2F-dependent transcription. E2F binds to DNA as a homodimer or as a heterodimer in association with TDP1/2, the heterodimer having increased binding efficiency. The crystal structure of an E2F4-DP2-DNA complex shows that the DNA-binding domains of the E2F and DP proteins both have a fold related to the winged-helix DNA-binding motif. Recognition of the central c/gGCGCg/c sequence of the consensus DNA-binding site is symmetric, and amino acids that contact these bases are conserved among all known E2F and DP proteins.
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 3 1.1e-22 1.1e-18 67.8 0.0 1 65 53 119 53 119 0.91
2 3 1.8 1.7e+04 -3.3 0.0 11 29 125 142 124 143 0.68
3 3 4.2e-17 4e-13 49.9 0.1 1 64 154 244 154 245 0.90

Sequence Information

Coding Sequence
ATGTATGAAGATGACAACATAACTTGTACTCCAAAGCGATGCGTCCTCACTGAAGTCACAAATTCAACTAACTATGTGTCGCCAACTGCTAATCTAAAGTTACTGACAAATGTTGCACTACAATACCCTACTCCGCCACCGAGTACTGTGCATCGAAAAGAAAAATCCCTACAGATACTATGTGACAGATTCCTTCATCTGTATCCTCTTAATGGGGATGGCCCAGTGGAAATACAGTTGGATAGCACTGCAACCAGGCTAGGTGTGGAAAAACGTCGAATGTATGACATTATTAATATTCTTGAAGCTATGCAGTGTGCTGTTCACAAAAGAAAGAACACATATCTTTGGCATGGAGGCTCTCGGCTGAATTCCTTCCTAAAGATGCTTAAAAAGCAAGGAGAACACCTGAAGCTATCAGATGCTCTGCGGGGTAAAGCTCCTAAGCCTCCCACTCCAAAGCACAAGACTCTGGGAGTGTTGGCACAGAGATTTCTAATGTTATTTTTAGTTGAACCTCCTAATACTCTAATAAACCTGGAGATGGCTGTGAGAGTGCTCATAGACACAACTAATAAGACTAAAACAGTGATCTCCCCTGAGCAACAGGACCGTCAACACAAGTCTAAAGTGAGGCGACTGTATGACATTGCCAATGTATTTATTTCTATTGGTCTCATTGAAAAAGTGTCAGGTAATTTAATATTAAAAAAGCCAGTTTTTAAGTATGTGGGGCCGCATAAGATAAAATGTGACAAGGCAGCACTGGACACTCCATCACCTATAACACCACTCTCGGCATTGGACAACCAGCAGCGCACTCCAGCATGCCATGTGTTTGCTGGGCGGTCCAAACGGAAACTGGAGTTCACAACTCCAACTTCCACCAAAGAACTTAAGTTTGGTATAACAACCCCACCTCACACACCGTCACACAAGTGGGATGAGATCCTACTTGTTGCTGACATGGAACTGACTAGAATTAACAATGGAGTTGTCTTGTGA
Protein Sequence
MYEDDNITCTPKRCVLTEVTNSTNYVSPTANLKLLTNVALQYPTPPPSTVHRKEKSLQILCDRFLHLYPLNGDGPVEIQLDSTATRLGVEKRRMYDIINILEAMQCAVHKRKNTYLWHGGSRLNSFLKMLKKQGEHLKLSDALRGKAPKPPTPKHKTLGVLAQRFLMLFLVEPPNTLINLEMAVRVLIDTTNKTKTVISPEQQDRQHKSKVRRLYDIANVFISIGLIEKVSGNLILKKPVFKYVGPHKIKCDKAALDTPSPITPLSALDNQQRTPACHVFAGRSKRKLEFTTPTSTKELKFGITTPPHTPSHKWDEILLVADMELTRINNGVVL