Basic Information

Transcription Factor Domain

TF Family: MBD
Domain: MBD domain
PFAM: PF01429
TF Group: Unclassified Structure
Description: The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 2 3.3e-26 2.1e-22 79.3 0.0 2 72 4 69 3 73 0.94

2 2 0.00049 3.1 8.3 0.1 18 72 78 145 76 150 0.75

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	2	3.3e-26	2.1e-22	79.3	0.0	2	72	4	69	3	73	0.94
2	2	0.00049	3.1	8.3	0.1	18	72	78	145	76	150	0.75

Coding Sequence: ATGTCTATTGATAAGAAAAAATTTGATTGCTCTGCCTTACCTAAAGGATGGCAGCGAGAAGAAATTGTTCGAAAGTCCGGCTTGTCTGCGGGCAAGGTGGATATCTACTACTACAGTCCCTCAGGCCACCGGTTCCGCAGCAAACCTCAACTGGCACGGTACTTGGGAGATACTGTTGATCTCTCCTCATTTGACTTTAGGACTGGCAATATTAACAATAACGCCTTAAGAAAAACGAAACAGAGGCCAAGAGGGATTCAATTCGATTACAGTCGCGGAGTGAGGACAGATGCGTCCTTGGTACCACCAATACGACAAACAGCATCCATTTTTAAACAACCTGTTACTGTTCACAAATCTCAAGAAGGAAAAGTTAAGACTGATTTTAAACAAGGATCCCAAGATAAACCCAAACAGCTATTTTGGGAAAAGCGTTTGGAAGGCCTTCGAGCTTGTGATATTGATGGACTTGAATTAGACGCAATGGAATTGCCCAAGAGCTTACGCCCGGTTGGTCCACATGTAGGAGATGAAACCTTACTGCAATCAGTTGCTACAGCATTGCATGTTTCAACGCAACCTGTTACCGGCCAAACTGGGAGCCGTTCTGCTTTAGATAGAAACCCAGGAGTATTTTTAAACCCAGAACAACCGCTTGTGCAGGCAGTGCAGGTTATAGATGACGACATCAAACGACAAGAAGACCGTGTTATATCTGTCAGGAAAAAATTACAAGAAGCTCTTAAAGCTTAG
Protein Sequence: MSIDKKKFDCSALPKGWQREEIVRKSGLSAGKVDIYYYSPSGHRFRSKPQLARYLGDTVDLSSFDFRTGNINNNALRKTKQRPRGIQFDYSRGVRTDASLVPPIRQTASIFKQPVTVHKSQEGKVKTDFKQGSQDKPKQLFWEKRLEGLRACDIDGLELDAMELPKSLRPVGPHVGDETLLQSVATALHVSTQPVTGQTGSRSALDRNPGVFLNPEQPLVQAVQVIDDDIKRQEDRVISVRKKLQEALKA*

Sequence clustering based on sequence similarity using MMseqs2