Basic Information

Gene Symbol
MBD3
Assembly
GCA_947363495.1
Location
OX376168.1:7238530-7246037[-]

Transcription Factor Domain

TF Family
MBD
Domain
MBD domain
PFAM
PF01429
TF Group
Unclassified Structure
Description
The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 2 2.1e-27 9.8e-24 83.4 0.1 1 72 5 71 5 75 0.95
2 2 0.002 9.4 6.6 0.1 29 73 93 149 79 152 0.80

Sequence Information

Coding Sequence
ATGAATATTTCTATTGAAAAGAAACGATCAGATTGTTCAGCTTTACCCAAAGGATGGCAAAGGGAAGAAGTATTGAGAAAAACTGGGCTAACAGCTGGAAAAGTTGACGTTTATTATTACAACCCTACAGGTAAAAAGTTTCGCAGTAAACCCGAGCTAGTTCGTTATCTCGGTGATAGTATGGACCTGTCATGTTTCGACTTCCATCAGGGTCAAATAAACACAATGCTGCTGTGCAAGGCCAAGAAAGCACGTGCTCAGTTCGATTACAGGGGTGTCCGCTCAGACGCGTCGCTAGTGCCACCTATACGACAAACAGCATCCATTTTTAAGCAACCAGTCACTGTCTACAAGACTCAGGAGAGCAAGGTGAAGACTGACCAGAAACATGAACGTACTGGAGACAAGCAAGAGAAGCCGAAGCAGTTGTTTTGGGAAAAAAGACTTGAGGGCCTTACTGCGTGCGACGCCAATGGTGTAATTGGAACAACATCCCTTCCAAAGTACATTAAGTCACTGGGACCATACACTTCTGATGCCACTACCATTCAGTCCTTGGCAACGGCTTTGCATGTCTCATCTCAGCCAATAACTGGACAAACCGGGTCCAAACAAGCAATAATGGAAAATCCTGGAGTTTTTTTAAACCCTGAACAGCCGCTGATCGCAGCGGTCACCATTACGAAAGAGGACGTGCGGCGACAGGAGGAGCGCGTGAAACGAGCGCGCCTTCGTTTGCAGTGCGACGGCGCCGGGCCCGCCGCGGGCGCCGGCGCACTGCCCGAGCTGCCCGACTCTTCCGCATTGCCCTGCTCGTCCGCTCTGCCCTGCTCGTCCGCTCTGCCCTGCTCATCCGCACTGCCCTGCCCGTCCGCGCTGCCCTGCTCGCCGCCAGACTCCACGCAGCCCGACTCCACCACGCTGCCAGACTCCACGCAACACTCGCCTAGACTGCTCGTCGATGGTGACTCCAACGCCGAGAGTAATGACAACGAGTGCGTGCTAGAATCTCTTTGA
Protein Sequence
MNISIEKKRSDCSALPKGWQREEVLRKTGLTAGKVDVYYYNPTGKKFRSKPELVRYLGDSMDLSCFDFHQGQINTMLLCKAKKARAQFDYRGVRSDASLVPPIRQTASIFKQPVTVYKTQESKVKTDQKHERTGDKQEKPKQLFWEKRLEGLTACDANGVIGTTSLPKYIKSLGPYTSDATTIQSLATALHVSSQPITGQTGSKQAIMENPGVFLNPEQPLIAAVTITKEDVRRQEERVKRARLRLQCDGAGPAAGAGALPELPDSSALPCSSALPCSSALPCSSALPCPSALPCSPPDSTQPDSTTLPDSTQHSPRLLVDGDSNAESNDNECVLESL

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

90% Identity
iTF_00146439;
80% Identity
-