Basic Information

Gene Symbol
MBD3
Assembly
GCA_947044225.1
Location
CAMRHB010000027.1:4634327-4639913[-]

Transcription Factor Domain

TF Family
MBD
Domain
MBD domain
PFAM
PF01429
TF Group
Unclassified Structure
Description
The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 2 4.5e-28 1.2e-24 86.1 0.1 1 72 5 71 5 75 0.95
2 2 0.0029 7.8 6.6 0.1 29 73 93 149 79 152 0.80

Sequence Information

Coding Sequence
atgaaCATTTCTATTGAAAAGAAACGATCAGATTGTTCTGCTTTGCCCAAAGGATGGCAAAGggaagaagtattgagaaaaacTGGGCTAACTGCTGGAAAAGTTGATGTTTATTATTACAGCCCTACAGGTAAAAAGTTTCGCAGTAAACCCGAGCTAGTTCGTTATCTCGGTGATAGTATGGATCTGTCGTGTTTCGACTTCCATCAGGGTCAAATAAACACAATGCTGCTGTGCAAGGCCAAGAAAGCACGCGCTCAGTTCGATTACAGGGGTGTCCGCTCGGACGCGTCACTAGTGCCACCTATACGACAAACAGCATCAATTTTTAAGCAACCAGTCACTGTGTACAAGACACAGGAGAGCAAGGTGAAGACTGACCAGAAACATGAACGCACGGGAGACAAGCAGGAGAAGCCAAAGCAGTTGTTTTGGGAAAAGAGACTTGAGGGTCTTACCGCCTGCGACGCTAATGGTGTGATCGGAACAACGTCTCTTCCAAAGTACATAAAGCCGCTGGGACCATATAATTCTGATGCTACTACTATCCAGTCTTTGGCAACGGCGCTGCATGTCTCATCTCAGCCAATAACtgGGCAAACTGGATCAAAACAAGCAATAATGGAAAACCCTGGAGTTTTTTTAAACCCTGAGCAGCCGCTGATCGCCGCGGTGACCATCACCAAGGAAGACGTGCGTCGGCAGGAGGAGCGCGTGAAGCGAGCGCGCCTTCGATTGCAGCAGTGCGACGGCGCCGGGCCCGCCGCGGGCTCCGGCGACGAGCCCGAGATCCCGGACTCGTGCGAGCTCCCGGACTCGTGCGAGCTCCCGAATTCGTGCGAGCTCCCCGACTCGTGCGTGCTGCCAGACTCCACCCAGCCAGACTCCACCACCCTGCCAGACTCCACGCAACTCTCGCCCAAACTGCTCGCTGACGCCGACTCCAACGCCGAAAGTAATGACAACGAATGCGTGCTAGAATCTCTATAA
Protein Sequence
MNISIEKKRSDCSALPKGWQREEVLRKTGLTAGKVDVYYYSPTGKKFRSKPELVRYLGDSMDLSCFDFHQGQINTMLLCKAKKARAQFDYRGVRSDASLVPPIRQTASIFKQPVTVYKTQESKVKTDQKHERTGDKQEKPKQLFWEKRLEGLTACDANGVIGTTSLPKYIKPLGPYNSDATTIQSLATALHVSSQPITGQTGSKQAIMENPGVFLNPEQPLIAAVTITKEDVRRQEERVKRARLRLQQCDGAGPAAGSGDEPEIPDSCELPDSCELPNSCELPDSCVLPDSTQPDSTTLPDSTQLSPKLLADADSNAESNDNECVLESL

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00720311;
90% Identity
iTF_00720311;
80% Identity
-