Basic Information

Transcription Factor Domain

TF Family: E2F
Domain: E2F_TDP domain
PFAM: PF02319
TF Group: Helix-turn-helix
Description: This family contains the transcription factor E2F and its dimerisation partners TDP1 and TDP2, which stimulate E2F-dependent transcription. E2F binds to DNA as a homodimer or as a heterodimer in association with TDP1/2, the heterodimer having increased binding efficiency. The crystal structure of an E2F4-DP2-DNA complex shows that the DNA-binding domains of the E2F and DP proteins both have a fold related to the winged-helix DNA-binding motif. Recognition of the central c/gGCGCg/c sequence of the consensus DNA-binding site is symmetric, and amino acids that contact these bases are conserved among all known E2F and DP proteins.
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 3 1e-22 5.5e-19 67.9 0.0 1 65 53 119 53 119 0.94

2 3 1.3 7.1e+03 -2.9 0.0 11 29 125 142 124 144 0.73

3 3 1.4e-16 7.5e-13 48.2 0.1 1 59 154 233 154 245 0.89

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	3	1e-22	5.5e-19	67.9	0.0	1	65	53	119	53	119	0.94
2	3	1.3	7.1e+03	-2.9	0.0	11	29	125	142	124	144	0.73
3	3	1.4e-16	7.5e-13	48.2	0.1	1	59	154	233	154	245	0.89

Coding Sequence: ATGTATGAAGATGACAACATAACTTGTACTCCTAAACGCTGCGTGCTCACCGAAGTCACCAACTCTTCTAGTTATGTCTCGCCGAATGCTAACCTCAAGCTCCTCACGAACGTCGCACTTCAGTACCCAACACCGCCCCCGAGTGCGGTGCAACGCAAAGAAAAATCCCTTCAAATACTATGCGACAGATTCCTCAACCTTTATCCCTTGCATGGGAACGGCACAGTGGAGATACAACTGGACACGACTGCAGCGAGCCTGGGAGTGGAGAAGCGGCGAATGTATGACATAATCAACATACTGGAAGCTATGCAATGTGCAGTACATAAGAGGAAAAACACTTATCTTTGGCATGGAGGTTCCCGATTAAATGGTTTTCTCAAAATGTTGAAGAGACAAGGAGAAAATTTAAAGCTCTCAGAAGTGCTTCGTGGCAGAGCTCCAAAACCACCAACACCGAAACACAAGACTTTAGGGGTGCTGGCACAGAGATTTCTAATGTTATTTTTGGTTGAACCTCATAATACTTTAATAAACCTGGAAATGGCAGTAAGAGTGCTCATTGACACTTCAAACAAAAGCAAGACTGTTCTTTCTCCTGAGCAACAAGAACGACAGCACAAGTCTAAAGTAAGACGGCTTTATGATATTGCCAATGTATTTATTTCTATTGGTCTCATTGAAAAGGTTTCTGGTAATTTGATACTGAAGAAGCCAGTATTTATATATGTAGGGCCATATAAACCGAAAACCGCTGAAAAGGTGGTGGTGTCCACCCCATCACCTATCACACCGCTTGCTGTCTTAGACAGCCAGGGGAGAGCTTCATCATGTCAAGTGTATGCGGGGAAGTCCAAAAGGAAGCTGGAGTTTACCACTCCTAGTAGTTCTCGAGAACTAAAGCTTGGAATCACAACCCCTCCCCACACCCCATCTCACAAGTGGGATGACATCTTGCTTGTGGCAGACATGGAACTGACTAGAATTAACAATGGTGTTATGTTGTGA
Protein Sequence: MYEDDNITCTPKRCVLTEVTNSSSYVSPNANLKLLTNVALQYPTPPPSAVQRKEKSLQILCDRFLNLYPLHGNGTVEIQLDTTAASLGVEKRRMYDIINILEAMQCAVHKRKNTYLWHGGSRLNGFLKMLKRQGENLKLSEVLRGRAPKPPTPKHKTLGVLAQRFLMLFLVEPHNTLINLEMAVRVLIDTSNKSKTVLSPEQQERQHKSKVRRLYDIANVFISIGLIEKVSGNLILKKPVFIYVGPYKPKTAEKVVVSTPSPITPLAVLDSQGRASSCQVYAGKSKRKLEFTTPSSSRELKLGITTPPHTPSHKWDDILLVADMELTRINNGVML

Sequence clustering based on sequence similarity using MMseqs2