Mbra002046.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Mamestra brassicae
Gene Symbol
Mef2
Assembly
GCA_905163435.1
Location
LR990988.1:5444871-5453934[+]

Transcription Factor Domain

TF Family
SRF
Domain
SRF domain
PFAM
PF00319
TF Group
Helix-turn-helix
Description
Serum response factor (SRF) is a ubiquitous nuclear protein important for cell proliferation and differentiation. SRF function is essential for transcriptional regulation of numerous growth-factor-inducible genes, such as c-fos oncogene and muscle-specific actin genes. A core domain of around 90 amino acids is sufficient for the activities of DNA-binding, dimerisation and interaction with accessory factors. Within the core is a DNA-binding region, designated the MADS box [2], that is highly similar to many eukaryotic regulatory proteins: among these are MCM1, the regulator of cell type-specific genes in fission yeast; DSRF, a Drosophila trachea development factor; the MEF2 family of myocyte-specific enhancer factors; and the Agamous and Deficiens families of plant homeotic proteins. In SRF, the MADS box has been shown to be involved in DNA-binding and dimerisation [1]. Proteins belonging to the MADS family function as dimers, the primary DNA-binding element of which is an anti-parallel coiled coil of two amphipathic α-helices, one from each subunit. The DNA wraps around the coiled coil allowing the basic N-termini of the helices to fit into the DNA major groove. The chain extending from the helix N-termini reaches over the DNA backbone and penetrates into the minor groove. A 4-stranded, anti-parallel β-sheet packs against the coiled-coil face opposite the DNA and is the central element of the dimerisation interface. The MADS-box domain is commonly found associated with K-box region see (IPR002487).
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 1 2.5e-28 1.9e-24 85.6 0.4 1 48 10 57 10 57 0.99

Sequence Information

Coding Sequence
ATGGGTCggaagaaaatacaaatatcccGGATTACGGACGAACGGAATCGACAGGTGACCTTCAACAAGCGCAAATTCGGTGTGATGAAGAAAGCCTATGAGCTTAGCGTACTGTGTGACTGTGAGATCGCTCTCATCATCTTCAGCTCCAACAACAAACTCTACCAATATGCCAGCACTGATATGGACAAGgTTCTTTTGAAATACACGGAATACAACGAGCCGCACGAGTCTCTGACAAACCGCAACATCATCGAGGCACTAACGAAGAAAGAGCATAAGAACGGAGTGATGTCACCGGACAGCCCCGAGGCTGAGCCCGAGTACAACCTGACACCAAGGACCGAGGCAAAGTATTCCAAGATTGATGAGGAATTCCAAATGATGATGCAGAGAAACCAGTTGAACGGGAGCCGAGTGGGAGTGGGCGTGGCAGGAAGCAACTACAACCTGCCCGTCAGCGTCCCTGTCGGCAACTACGATCAGACACTACTGCAAGCTAGTCCACAGATGCATACTTCTATCAGTCCACGGCCCTCGTCTTCGGAAACCGATTCAGTATACCCAAGCGGCGGAATGTTAGAGATGTCAAACGGCTACCCCGGCTCAGGGTCTCCGCTGGACGCGGGTTGCACGCCGTCGCCGTCACCCGGGCCAGCGCCGTCGCCGCACCGGCACGCGCACAAGTCGCACGGAcatgcgccgccgccgcaccACTCACCGCGACACAACAACCTGCGCGTCGTCATACCCAGCTCTATGCCGCCACCGCAGGACGACATATCTTATGCTGGAGAGACACCTCTCGGCTACTCAGGACTCGGCAACTTCGGACCACAGGACTTCAGCATCAACTCGGACATGGGCATCGGACTGACGTGGGGCGCGCACCAGCTGCAGACGCTACAGCACAACAGTAGCAGCTTGCCAGTCCTGGGCGGCGGGACGCCCCCCCCGGCAGCGTCGCCCAGTAACGTGAAGATCAAAGCCGAGCCAGTGTCGCCTCCTCGCGCCCCGGATCACATGCATCGCGCGCCgccgcctgcgcccgcgcctCAGCCCGCCCATCTCTCTGGAGTCATTGATGTGTATCGGCACGTTGCAGGTTCAGTATCGTCGAGCAACATGGGCTCGCCAGCCGGGCAAGACATGCGCCACTCCAGCGCGGGACCGCTTGACTATGAGCAACCGCACACGAAGCGGCCGCGAATCGAGGGCTGGGCCACATAG
Protein Sequence
MGRKKIQISRITDERNRQVTFNKRKFGVMKKAYELSVLCDCEIALIIFSSNNKLYQYASTDMDKVLLKYTEYNEPHESLTNRNIIEALTKKEHKNGVMSPDSPEAEPEYNLTPRTEAKYSKIDEEFQMMMQRNQLNGSRVGVGVAGSNYNLPVSVPVGNYDQTLLQASPQMHTSISPRPSSSETDSVYPSGGMLEMSNGYPGSGSPLDAGCTPSPSPGPAPSPHRHAHKSHGHAPPPHHSPRHNNLRVVIPSSMPPPQDDISYAGETPLGYSGLGNFGPQDFSINSDMGIGLTWGAHQLQTLQHNSSSLPVLGGGTPPPAASPSNVKIKAEPVSPPRAPDHMHRAPPPAPAPQPAHLSGVIDVYRHVAGSVSSSNMGSPAGQDMRHSSAGPLDYEQPHTKRPRIEGWAT*

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00687854;
90% Identity
iTF_00973761; iTF_01076483; iTF_00172932; iTF_00301153; iTF_01094018; iTF_00017316; iTF_01361604; iTF_00302086; iTF_01117191; iTF_00446122; iTF_01439915; iTF_01377452; iTF_00745677; iTF_00667470; iTF_00383631; iTF_01338736; iTF_00042610; iTF_00374098; iTF_00784371; iTF_00924660; iTF_01093076; iTF_01342196; iTF_00124247; iTF_01192696; iTF_00000313; iTF_00041753; iTF_00049883; iTF_00123355; iTF_00647969; iTF_00726337; iTF_00037794; iTF_00758148; iTF_00831205; iTF_00274407; iTF_00122376; iTF_00120489; iTF_00273581; iTF_00121423; iTF_00177103; iTF_00425362; iTF_01246962; iTF_00237557; iTF_00907861; iTF_00071417; iTF_00810044; iTF_00809117; iTF_00711842; iTF_01084244; iTF_01063740; iTF_01064642; iTF_01533027; iTF_00685417; iTF_00928682; iTF_01061870; iTF_01531996; iTF_00783459; iTF_01230563; iTF_01028273; iTF_01031123; iTF_00888246; iTF_01030205; iTF_01029246; iTF_01527204; iTF_00364006; iTF_00445158; iTF_00282375; iTF_01027306; iTF_00072140; iTF_00147438; iTF_01285518; iTF_01362414; iTF_01441070; iTF_01119311; iTF_01118290; iTF_00111640; iTF_00279089; iTF_01502954; iTF_01026161; iTF_00907027; iTF_01425043; iTF_01533910; iTF_00043479; iTF_00039792; iTF_00621976; iTF_01387576; iTF_01386684; iTF_01388446; iTF_01340089; iTF_01534809; iTF_01062779; iTF_01085215; iTF_00345787; iTF_00622811; iTF_00906132; iTF_00677595; iTF_00040796; iTF_00208860; iTF_01363089; iTF_00207892; iTF_00375196; iTF_00785980; iTF_00449085; iTF_00281310; iTF_00785182; iTF_00018143; iTF_00038752; iTF_00036702; iTF_00323488; iTF_00791174; iTF_00448115; iTF_00968006; iTF_01204867; iTF_00114924; iTF_00878828; iTF_01205676; iTF_01203214; iTF_01204015; iTF_01206526; iTF_00932531; iTF_00889192; iTF_00931385; iTF_00185288; iTF_00186155; iTF_01221551; iTF_01260081; iTF_00432178; iTF_01547529; iTF_00171733; iTF_01073591; iTF_00947867; iTF_01180286; iTF_01179466; iTF_01487678; iTF_00327058; iTF_00779478; iTF_00782615; iTF_00180448;
80% Identity
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