Basic Information

Transcription Factor Domain

TF Family: zf-GAGA
Domain: zf-GAGA domain
PFAM: PF09237
TF Group: Zinc-Coordinating Group
Description: Members of this family bind to a 5'-GAGAG-3' DNA consensus binding site, and contain a Cys2-His2 zinc finger core as well as an N-terminal extension containing two highly basic regions. The zinc finger core binds in the DNA major groove and recognises the first three GAG bases of the consensus in a manner similar to that seen in other classical zinc finger-DNA complexes. The second basic region forms a helix that interacts in the major groove recognising the last G of the consensus, while the first basic region wraps around the DNA in the minor groove and recognises the A in the fourth position of the consensus sequence [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 10 0.019 2.3e+02 4.0 0.0 18 52 19 53 12 55 0.87

2 10 0.12 1.6e+03 1.3 0.1 21 43 50 72 46 77 0.89

3 10 0.00022 2.8 10.1 0.2 18 46 74 103 68 110 0.79

4 10 0.036 4.5e+02 3.1 0.0 21 46 106 131 101 138 0.83

5 10 0.22 2.8e+03 0.5 0.1 21 43 134 156 122 160 0.75

6 10 0.00021 2.6 10.2 0.1 18 48 158 189 153 193 0.81

7 10 0.0088 1.1e+02 5.0 0.1 21 47 190 216 188 223 0.84

8 10 0.17 2.2e+03 0.9 0.1 21 44 218 241 213 249 0.84

9 10 0.00065 8.1 8.6 0.3 21 45 274 298 266 305 0.77

10 10 0.029 3.6e+02 3.4 0.0 23 46 304 327 298 329 0.87

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	10	0.019	2.3e+02	4.0	0.0	18	52	19	53	12	55	0.87
2	10	0.12	1.6e+03	1.3	0.1	21	43	50	72	46	77	0.89
3	10	0.00022	2.8	10.1	0.2	18	46	74	103	68	110	0.79
4	10	0.036	4.5e+02	3.1	0.0	21	46	106	131	101	138	0.83
5	10	0.22	2.8e+03	0.5	0.1	21	43	134	156	122	160	0.75
6	10	0.00021	2.6	10.2	0.1	18	48	158	189	153	193	0.81
7	10	0.0088	1.1e+02	5.0	0.1	21	47	190	216	188	223	0.84
8	10	0.17	2.2e+03	0.9	0.1	21	44	218	241	213	249	0.84
9	10	0.00065	8.1	8.6	0.3	21	45	274	298	266	305	0.77
10	10	0.029	3.6e+02	3.4	0.0	23	46	304	327	298	329	0.87

Coding Sequence: ATGCATAAAGTACTATCGACGCCCGGTTCGAATATTGTAGCGGCGTCCGGGACCCGAGCCGCTCACACCGACCCCACCTCCTGCGCAGTCTGCGGCAAAAAGTTCAAGAAAGCGAGCGTGCTGAAGGTCCACATGCGACTCCACACAGGAGAGAAACCCTTTCCCTGCAACATGTGCGAGAAGCGATTTAACCAACTGATCCATTTGAAGAGACACGAGCAAGCTCACAGCGAACAAAAAGATTTCACTTGCCCGATATGTGCAAAACAGTTCTCGCAGCCCAGCGACTTTAAGAGACATGGACGAATTCACACAGGAGAGAAACCGTATAAGTGTGATATCTGTAATAAAGGGTTTACGCAGATGGGCTCGTTGAAGACGCACGCGCGAGTGCATACTGGAGAAAAACCTTACGGCTGCGAAATGTGTGTGAAGCGATTCGCGCAACATTACCAGTTGAAGGTACACGAACGTAGTCACACTGGAGAAAAACCATACAGTTGCGAAATCTGCGACAAACGGTTTACGAAAGCGGTGGACTTGCGGAGGCACGTGCGTGTGCACACTGGGGAGAAACCGTTCTCCTGTGCCATATGCAAAAAAGAGTTTTCAGATGTGTTGTATTTAAGACGACATCGACGAGTTCACACTGGTGAAAAGCCGTACGCGTGCGAAACGTGTAAACGAGAGTTTACAGAATGGGGCAGTTTGAGGAGACACGAGCGGGTTCACTCGGGAGACCGGCCTTACCCCTGCGAGACATGCGGGAAGCGTTTCAAAATACGGCACTCTTTAAAAATGCACAACCGAATACACACAGGTGAGAGACCCCATTCCTGTCCTATTTGCGAGAAGAAGTTCATAGACACGAGCAGGTTGAGAAAACACGAGCGGATACACACAGGCCTAAAACCATTCACATGTGATATATGCTCAAAGGACTTTACTGAAATGGGCAGTTTGAGGAAACATTCTCGACTTCACAATTGA
Protein Sequence: MHKVLSTPGSNIVAASGTRAAHTDPTSCAVCGKKFKKASVLKVHMRLHTGEKPFPCNMCEKRFNQLIHLKRHEQAHSEQKDFTCPICAKQFSQPSDFKRHGRIHTGEKPYKCDICNKGFTQMGSLKTHARVHTGEKPYGCEMCVKRFAQHYQLKVHERSHTGEKPYSCEICDKRFTKAVDLRRHVRVHTGEKPFSCAICKKEFSDVLYLRRHRRVHTGEKPYACETCKREFTEWGSLRRHERVHSGDRPYPCETCGKRFKIRHSLKMHNRIHTGERPHSCPICEKKFIDTSRLRKHERIHTGLKPFTCDICSKDFTEMGSLRKHSRLHN

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00658662;
90% Identity: iTF_00657477; iTF_00658662; iTF_00656358; iTF_00656806; iTF_00659131;
80% Identity: iTF_00657477;