Dvar012501.1
Basic Information
- Insect
- Drosophila varians
- Gene Symbol
- ken1
- Assembly
- GCA_018150405.1
- Location
- JAECWK010000135.1:3636984-3639097[+]
Transcription Factor Domain
- TF Family
- zf-C2H2
- Domain
- zf-C2H2 domain
- PFAM
- PF00096
- TF Group
- Zinc-Coordinating Group
- Description
- The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 12 0.0005 0.047 13.9 3.0 3 23 180 200 178 200 0.96 2 12 0.00055 0.052 13.8 0.1 1 23 206 231 206 231 0.93 3 12 0.0059 0.56 10.6 0.1 3 23 240 263 238 263 0.93 4 12 1.3 1.2e+02 3.2 0.4 2 11 276 285 275 292 0.80 5 12 8.7 8.2e+02 0.6 0.7 14 23 317 326 316 326 0.89 6 12 0.0036 0.34 11.3 0.1 1 23 332 354 332 354 0.98 7 12 0.0024 0.23 11.8 2.1 1 23 360 383 360 383 0.97 8 12 0.0065 0.61 10.4 4.0 1 23 389 411 389 411 0.96 9 12 0.00055 0.051 13.8 2.9 2 23 418 439 417 439 0.96 10 12 0.00018 0.017 15.3 1.1 3 23 528 549 526 549 0.95 11 12 0.0069 0.65 10.4 0.7 1 19 555 573 555 577 0.95 12 12 1.2e-06 0.00011 22.2 0.9 1 23 583 605 583 605 0.98
Sequence Information
- Coding Sequence
- ATGGCCACCAGGAATCGCCAAGCAGTGGCCCATAGGCTATGTCGGATTTGTCTACTGGAAATGGAGCAGCCTGTTTGGCACGATTTGTTCCAGGAACCACAGCTGGCTAACAAATTCAAAGTTTGCTCCTCTCTGGATGCTGACAAAGAGGACGGATTTCCGAGCCTCCTTTGCGAAACTTGCTATAGAAAGCTAAACGAGCTCCACGGTTTCAGGGAATTGTGCCTGAGTTCCAAACAGCGTTTCAAGGATATGTTGGCCAGTAATTTGGTTAGTCCAATTGAAGTATTTGAATCCGTCAGGGAGGATTCTGAGGTGGAGGAGCAGGCCAACTTTGATCCCCTGTTAAACCACAAACTGGAGATTATTGACAACGAGGAGGAGGTGTTCAAGATGTTGGAGACAGTCGACAAGGAGGAGCAACGAATTTCAGAGGAATCTTTAAAAAATGAAGAAGACGAGGGCGAGGATGAAAAGCCGCTGGCCAAGCGGCAGTGCAATCAGAGTATGATGCGTCAACGTCCTCAACTTATTAATTGTCCTATTTGCCAGCAAAAGTTCAAAAAGCAATCCAAATACGACGAGCACATGAAGCATCACAACAATTTGTTGCCATTCCAGTGCTCGGAGGAGACTTGCAAGAAGGGCTTCACCACAGCGGGAGCCCTGCGTCTCCATGTCGACTATGCACATACGAAAAAGTCCAATGAGATCCCCTGCACCGTGGACGGCTGTAAGCTGATCTTTCCTCGTCTCCGCCTGCTAACGATTCACCTGAAAAAAGTTCACAACCAGACCAGGGTGAGTGCGCCTCGTAGGGATCAGCCCTGTCGCGAATGTGGGATGGTGTTCCGTTGCCCAGTGGCTTTGAAGAAGNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNCACATAAACAGTGCTTTAAAAAATCACCTGCTGCGACATGCCGGGATCAAGAACTACGTTTGCCCATATTGCGGAGTGGGGAAAACCACCAGGCAGGAGTGGAGCAAGCACATCCTCACCCATACTCAGGAGAAGCAGTTTAAGTGCCAGGTCTGCGACCACGCCACCCACACGAAAAGAGCCTTGGAAAGCCACGTGAAGATTGTCCACGAGAAGGTCAGGAACTTTGCCTGCCAGTATTGCGGGAAGACTTTTGGAAAGTCGCACGCTTGTAAAATCCACGAAATGACCCACACGGGAGAGAAACGATGTGAGTGCAAGGTTTGCGGAAAGAAGTTTCTTTACACGGAAAGCCTGACTAAGCATCTAAAGATCCACGAGAAGAGCGTGGAACGGGCTTTGGAAACCTACCGTCAGCGGCAGGGCGATGGGGACATTTCCGACGCTCAGGTGAACGCGGATGAACTGCTAAAGGTCTGTGCGGAGTCTGTGGCGACCATTCCCAAAGATCCTCGCCGCGTTGAGCGAGTTGATCTGGCCCAACTGGCAGGGACAATAGTGAACCCCATTCCTACGATCCAGCTTCCGCCTAGCGAGACACCCGCTTGCACGAAATTCGTCCAGAAAGAAGGGATGCACTTGTGCCCGGGATGCAGTCAAGGATTCAACAATTTGGGAAACATGAAGCGCCACTACAAGAGCGTGCACGAAAAGGTTAAGGACTTTGAGTGCCGCTTCTGCGCTCGCCGCTTTGCCAACTCACAGTCCTTGAAGCAGCACGAGTGGATCCACACTGGGGAAAAACCGTACGAGTGCAAGAACTGCGGCACTCACTTCCGCCAGGAGGCGGCTCTCATTCGACACCTAAAGGTCCACGACGAGCGGCCATTGAAACCCTCAAGGCCTCCAAAGGAGATAACGGGCAGGGCGCGGCAGAAGGCTATCCAGAAATGCGCCCATAAGCGAAAGGTGGAAGCCCTCCGGGAGGAAATTGCCATGGTGGCCAAGGAGGAGCTGAAGGATCTGGAGAAGCAGCGCGCACTGGAAAAACAGCAAAATACCTACGAACAGTATCAGGCAGCAGCGGCCGAGCCAACCAAGTTTCCAGAGGAATCATAG
- Protein Sequence
- MATRNRQAVAHRLCRICLLEMEQPVWHDLFQEPQLANKFKVCSSLDADKEDGFPSLLCETCYRKLNELHGFRELCLSSKQRFKDMLASNLVSPIEVFESVREDSEVEEQANFDPLLNHKLEIIDNEEEVFKMLETVDKEEQRISEESLKNEEDEGEDEKPLAKRQCNQSMMRQRPQLINCPICQQKFKKQSKYDEHMKHHNNLLPFQCSEETCKKGFTTAGALRLHVDYAHTKKSNEIPCTVDGCKLIFPRLRLLTIHLKKVHNQTRVSAPRRDQPCRECGMVFRCPVALKKXXXXXXXXXXXXXXXXXXXXXHINSALKNHLLRHAGIKNYVCPYCGVGKTTRQEWSKHILTHTQEKQFKCQVCDHATHTKRALESHVKIVHEKVRNFACQYCGKTFGKSHACKIHEMTHTGEKRCECKVCGKKFLYTESLTKHLKIHEKSVERALETYRQRQGDGDISDAQVNADELLKVCAESVATIPKDPRRVERVDLAQLAGTIVNPIPTIQLPPSETPACTKFVQKEGMHLCPGCSQGFNNLGNMKRHYKSVHEKVKDFECRFCARRFANSQSLKQHEWIHTGEKPYECKNCGTHFRQEAALIRHLKVHDERPLKPSRPPKEITGRARQKAIQKCAHKRKVEALREEIAMVAKEELKDLEKQRALEKQQNTYEQYQAAAAEPTKFPEES
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- iTF_00477482; iTF_00504131; iTF_00476079; iTF_00550392; iTF_00546109; iTF_00615043; iTF_00539111; iTF_00488162; iTF_00580122; iTF_00566240; iTF_00481686;
- 90% Identity
- -
- 80% Identity
- -