Dsub003875.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Drosophila subsilvestris
Gene Symbol
ftz-f1
Assembly
GCA_035043285.1
Location
JAWNNB010001032.1:123797-135215[+]

Transcription Factor Domain

TF Family
SF-like
Domain
zf-C4|SF-like
PFAM
AnimalTFDB
TF Group
Zinc-Coordinating Group
Description
The ligand binding domain of nuclear receptor steroidogenic factor 1 (SF-1): SF-1, a member of the nuclear hormone receptor superfamily, is an essential regulator of endocrine development and function and is considered a master regulator of reproduction. Most nuclear receptors function as homodimer or heterodimers, however SF-1 binds to its target genes as a monomer, recognizing the variations of the DNA sequence motif, T/CCA AGGTCA. SF-1 functions cooperatively with other transcription factors to modulate gene expression. Phospholipids have been determined as potential ligands of SF-1. Like other members of the nuclear receptor (NR) superfamily of ligand-activated transcription factors, SF-1 has a central well conserved DNA binding domain (DBD), a variable N-terminal domain, a flexible hinge and a C-terminal ligand binding domain (LBD). [1, 8, 3, 11, 6, 5, 12, 10, 9, 2, 4, 7]
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 3 2 1.9e+04 -11.5 18.8 61 125 104 163 4 179 0.45
2 3 7.1e-20 6.9e-16 58.8 0.7 1 79 338 415 338 437 0.76
3 3 2.3e-54 2.3e-50 172.3 2.0 234 408 605 776 591 778 0.96

Sequence Information

Coding Sequence
ATGTTATTAGAAATGGATCAGCAACAGGCGACCGTACAGTTCATATCGTCGCTGAATATATCGCCGTTCAGCATGCaactcgagcagcagcagcagcagccctcgAGTCCGGCTCTGGCTGCCAATCAGCAGCCCCAAACGGgcccaaacaacaacaacaacaacagcagcagcggtggcagcaacaacaacaatgataACGACGGAAATGGTCTTTCCAAATTCGAACATGAATATAACGCGTATACGCTACAGCTAGCGAGTGGTGCAGGTGGTGCAGGTGTAGCAGGAGGCACTGTCAGtggcagccaacagcagcagcagcagcaccacagctcgcaccaccagcaacagcagcagtcggaCCCTCAGGGGCActaccaacagcagcagcagcagcaacagaataTTGCCAACAACGCCAACCAATTCAACTCCTCGTCCTATTCGTATATATACAACTTCGATTCACAGTATATATTCCCGACAGGCTACCAGGACACCACCTCCTCCCACTCACAGCAGAGTGGCGGTGGgggcggaggcggtggcggagCTGGCGGCAACATCCTCAACGGCAGTTCGGGTAGTAGCTCCGGCTACATGCTGCTGCCCCAAGCGGCCAGCTCCAGCGGCAACACCAATGCCGCCCACATGTCCTCCGCCAGCGGATCTGTTGGCAATGCCAGCGGGCCCAACGGTGGCGGAGGCGGCTCCGGCCCTGGCAATGCCATGGGCGGTACGAGTGCCACTCCGGGACACGGCGGCGAAGTGATCGACTTCAAGCACCTCTTCGAGGAGCTATGCCCCGTGTGCGGCGACAAGGTCAGTGGCTACCACTatggcctgctcacctgcgagtCTTGCAAGGGCTTCTTCAAGCGGACGGTCCAGAACAAGAAGGTCTACACCTGCGTGGCGGAGCGGTCGTGCCACATTGACAAGACGCAGCGCAAGCGGTGTCCCTACTGCCGCTTCCAGAAATGCCTAGAGGTAGGCATGAAGCTGGAGGCTGTGCGTGCGGATCGGATGCGGGGTGGCAGGAACAAGTTTGGTCCCATGTACAAGCGGGATCGGGCGCGGAAGCTGCAGGTGATGCGTCAGCGGCAGATCGCCCTCCAGGCGCTGCGCAACTCGATGGGGCCAGACATCAAGCCAACGCCGATCTCGCCGGGCTACCAGCAAGCATATCCAAATATGAACATTAAGCAGGAAATCCAAATACCTCAGGTATCCTCACTCACCCAATCGCCGGACTCGTCGCCCAGCCCCATAGCCATTGCTCTGGGCCAGGTGAATGCCAGCACGGGCGGAGTGATAGCCACGCCCATTAATGCCGGTAACGGAGGcagtggtggcggcggcagcggtggcggcATGAACGGCCCCAGCTCCGTGGGCAATGGCAatagcagcaacggcagcagcagcaacaacaacaacaccggCAGCAGCACAGGCAACGGAACAGGTGGCGCCGGCggaggtggcggcggcggtggtggcaacAATgcgggcggcggcggcaataACAGCTCCACCGATGGCCTGCATCGCAACGGCGGCGGCAATGGCAACTGCCACGAAGCTGGAATAGGATCTCTGCAGAACTCGGCCGACTCGAAACTGTGctTCGATTCTGGCACTCATCCATCGAGCACTGCCGATGCGCTTATCGAGCCACTGAGAGTCTCACCGATGATACGAGAATTTGTGCAATCGATCGACGATCGGGAATGGCAGACGCAGCTGTTCGCGCTGCTGCAGAAGCAGACCTACAACCAGGTGGAGGTGGATCTCTTTGAGCTGATGTGCAAGGATCTGAAGGTCGATGATCAAATGAAGCTGCTGCAACACTCCTGGTCGGACATGCTGGTCCTCGATCATCTGCACCATCGCATCCACAACGGACTGCCCGATGAGACGCAGCTGAACAATGGCCAGGTCTTCAATCTACTCAGTCTGGGGCTGTTGGGCGTGCCGCAATTGTCCGACTATTTCAATGAGCTGCAGAATAAGCTGCAGGATCTGAAATTCGACATGGGCGACTATGTGTGCATGAAATTCCTAATACTTTTGAATCCAAATGTGCGGGGCATTGTCAACAGGAAGACCGTGTCCGAGGGACATGATAATGTGCAGGCAGCCCTCCTGGACTACACCCTCACCTGTTATCCTTCAGTCAATGACAAATTCAGTAGGCTAGTGAACATCTTACCGGAAATCCATGCCATGGCCGCACGCGGCGAGGAGCACCTCTACTCCAAGCACTGTGCCGGCAGTGCACCCACCCAGACGCTGCTCATGGAGATGCTGCACGCCAAGCGGAAGGTGTAG
Protein Sequence
MLLEMDQQQATVQFISSLNISPFSMQLEQQQQQPSSPALAANQQPQTGPNNNNNNSSSGGSNNNNDNDGNGLSKFEHEYNAYTLQLASGAGGAGVAGGTVSGSQQQQQQHHSSHHQQQQQSDPQGHYQQQQQQQQNIANNANQFNSSSYSYIYNFDSQYIFPTGYQDTTSSHSQQSGGGGGGGGGAGGNILNGSSGSSSGYMLLPQAASSSGNTNAAHMSSASGSVGNASGPNGGGGGSGPGNAMGGTSATPGHGGEVIDFKHLFEELCPVCGDKVSGYHYGLLTCESCKGFFKRTVQNKKVYTCVAERSCHIDKTQRKRCPYCRFQKCLEVGMKLEAVRADRMRGGRNKFGPMYKRDRARKLQVMRQRQIALQALRNSMGPDIKPTPISPGYQQAYPNMNIKQEIQIPQVSSLTQSPDSSPSPIAIALGQVNASTGGVIATPINAGNGGSGGGGSGGGMNGPSSVGNGNSSNGSSSNNNNTGSSTGNGTGGAGGGGGGGGGNNAGGGGNNSSTDGLHRNGGGNGNCHEAGIGSLQNSADSKLCFDSGTHPSSTADALIEPLRVSPMIREFVQSIDDREWQTQLFALLQKQTYNQVEVDLFELMCKDLKVDDQMKLLQHSWSDMLVLDHLHHRIHNGLPDETQLNNGQVFNLLSLGLLGVPQLSDYFNELQNKLQDLKFDMGDYVCMKFLILLNPNVRGIVNRKTVSEGHDNVQAALLDYTLTCYPSVNDKFSRLVNILPEIHAMAARGEEHLYSKHCAGSAPTQTLLMEMLHAKRKV

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00581562;
90% Identity
iTF_00471643;
80% Identity
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