Basic Information

Insect: Drosophila pseudoobscura
Gene Symbol: ftz-f1
Assembly: GCA_009870125.2
Location: CM020872.1:46724582-46735822[+]

Transcription Factor Domain

TF Family: SF-like
Domain: zf-C4|SF-like
PFAM: AnimalTFDB
TF Group: Zinc-Coordinating Group
Description: The ligand binding domain of nuclear receptor steroidogenic factor 1 (SF-1): SF-1, a member of the nuclear hormone receptor superfamily, is an essential regulator of endocrine development and function and is considered a master regulator of reproduction. Most nuclear receptors function as homodimer or heterodimers, however SF-1 binds to its target genes as a monomer, recognizing the variations of the DNA sequence motif, T/CCA AGGTCA. SF-1 functions cooperatively with other transcription factors to modulate gene expression. Phospholipids have been determined as potential ligands of SF-1. Like other members of the nuclear receptor (NR) superfamily of ligand-activated transcription factors, SF-1 has a central well conserved DNA binding domain (DBD), a variable N-terminal domain, a flexible hinge and a C-terminal ligand binding domain (LBD). [1, 8, 3, 11, 6, 5, 12, 10, 9, 2, 4, 7]
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 3 2 2e+04 -13.6 22.9 45 112 103 166 4 182 0.58

2 3 8.1e-20 8.1e-16 58.6 0.8 1 79 344 421 344 442 0.76

3 3 2.7e-69 2.7e-65 221.5 1.7 164 408 562 799 540 801 0.91

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	3	2	2e+04	-13.6	22.9	45	112	103	166	4	182	0.58
2	3	8.1e-20	8.1e-16	58.6	0.8	1	79	344	421	344	442	0.76
3	3	2.7e-69	2.7e-65	221.5	1.7	164	408	562	799	540	801	0.91

Sequence Information

Coding Sequence: ATGTTATTAGAAATGGATCAGCAACAGGCGACAGTACAGTTTATATCGTCGCTGAATATATCGCCGTTCAGCATGcagctcgagcagcagcagcagcagccctcgAGTCCGGCTCTGGCCGCCAATCAGCAGCCCCAAACGggcgccaacaacaacaacaacagcagcagcagcggcggtggcaacaacaacaacaacaacgataaCGACGGAAATGGTCTTTCGAAATTCGAACATGAATATAACGCGTATACGCTTCAGCTAGCGGGTGGTGCAGGTGGGGCAGGAGGCACCGTCAGCGgcagccagcaacagcagcagcagcaccacagcacgcaccaccagcagcagcagcagcagcagcagtccgaCCAGCAGGGGCActaccaacagcagcagcagcagcagcagcaacaacagaataTTGCCAACAACGCCAACCAATTCAACTCCTCGTCCTACTCGTATATATACAACTTCGATTCACAGTATATATTCCCGACAGGCTACCAGGACACCACCTCCTCCCACTCGCAGCAGAGTGGCggtgggggcggcggcggtggcggagcTGGCGGCAACATCCTGAACGGCAGCTCGGGCAGCAGCTCCGGCTATatgctgctgccgcaggcTGCCAGCTCCAGCGGCAACACCAATGCCGCCCACATGTCCTCGGCCAGCGGATCCGTTGGCAACGCCAACGGCCccaacggcggcggcggcggcggttcCGGTCCTGGCAATGCCATGGGCGGCACGAGCGCCACCCCGGGCCACGGCGGCGAAGTGATCGACTTCAAGCACCTGTTCGAGGAGCTGTGCCCCGTGTGCGGCGACAAGGTCAGTGGCTACCACTACGGCCTGCTCACCTGCGAGTCCTGCAAGGGCTTCTTCAAGCGGACGGTCCAGAACAAGAAGGTCTACACCTGCGTGGCGGAGCGGTCGTGCCACATCGACAAGACGCAGCGCAAGCGGTGTCCCTACTGCCGCTTCCAAAAGTGCCTGGAGGTGGGCATGAAGCTGGAGGCTGTTCGAGCGGATCGGATGCGGGGTGGCAGGAACAAGTTCGGACCCATGTACAAGCGGGATCGGGCGCGGAAGCTGCAGGTGATGCGTCAGCGGCAGATCGCCCTCCAGGCGCTGCGCAACTCGATGGGGCCGGACATCAAGCCGACGCCGATCTCGCCGGGCTACCAGCAAGCATATCCAAATATGAACATTAAGCAGGAAATCCAAATACCTCAGGTATCCTCACTCACCCAGTCGCCGGACTCGTCGCCCAGCCCCATTGCCATTGCTCTGGGCCAGGTGAATGCCAGCGCGGGAGGAGTGATAGCCACGCCCATCAATGCCGGAAACGggggcagtggcggcggcggcggcggcggtggcggcctGAACGGCCCCAGTTCCGTGGGCAATGGCAatagcagcaacggcagcagcagcaacaacaccggCAGCAGCACAGGCAACGGGGCAGGTGGCgccggtggcggcggcggtggcaacaatgcgggcggcggcggcggcaataACAGCTCCACCGACGGCCTGCATCgcaacggcggcggcaacggcaactgcCACGAAGCTGGAATAGGATCTCTGCAGAACTCGGCCGACTCGAAACTGTGcttCGATTCCGGCACTCATCCATCGAGCACGGCCGATGCGCTTATCGAGCCACTAAGAGTCTCCCCGATGATACGAGATTTTGTGCAATCGATCGACGATCGGGAATGGCAGACGCAGCTGTTCGCGCTGCTGCAGAAGCAGACCTACAACCAGGTGGAGGTGGATCTCTTTGAGCTGATGTGCAAGGTGCTCGATCAGAATCTGTTCTCGCAGGTGGACTGGGCAAGGAACACGGTCTTCTTTAAGGATCTGAAGGTCGATGATCAAATGAAGCTGCTGCAACACTCCTGGTCGGACATGCTGGTCCTCGACCATCTGCACCATCGCATCCACAACGGGCTGCCCGATGAGACGCAGCTGAACAACGGCCAGGTCTTCAATCTACTCAGTCTGGGCCTGTTGGGCGTGCCGCAGCTGTCCGATTATTTCAACGAGATACAGAACAAGCTGCAGGATCTGAAATTCGACATGGGCGACTATGTCTGCATGAAATTCCTAATACTTTTAAATCCAACTGTACGCGGCATTGTCAACAGGAAGACCGTGTCGGAGGGACATGATAATGTGCAGGCGGCCCTGCTGGACTACACCCTCACCTGTTATCCTTCAGTCAATGACAAATTCAGTAGGCTAGTGAACATCCTACCGGATATCCATGCCATGGCCGCACGCGGCGAGGAGCACCTCTACATCAAGCACTGTGCCGGCAGTGCGCCCACCCAGACGCTGCTCATGGAGATGCTGCACGCCAAGCGGAAGGTGTAG
Protein Sequence: MLLEMDQQQATVQFISSLNISPFSMQLEQQQQQPSSPALAANQQPQTGANNNNNSSSSGGGNNNNNNDNDGNGLSKFEHEYNAYTLQLAGGAGGAGGTVSGSQQQQQQHHSTHHQQQQQQQQSDQQGHYQQQQQQQQQQQNIANNANQFNSSSYSYIYNFDSQYIFPTGYQDTTSSHSQQSGGGGGGGGGAGGNILNGSSGSSSGYMLLPQAASSSGNTNAAHMSSASGSVGNANGPNGGGGGGSGPGNAMGGTSATPGHGGEVIDFKHLFEELCPVCGDKVSGYHYGLLTCESCKGFFKRTVQNKKVYTCVAERSCHIDKTQRKRCPYCRFQKCLEVGMKLEAVRADRMRGGRNKFGPMYKRDRARKLQVMRQRQIALQALRNSMGPDIKPTPISPGYQQAYPNMNIKQEIQIPQVSSLTQSPDSSPSPIAIALGQVNASAGGVIATPINAGNGGSGGGGGGGGGLNGPSSVGNGNSSNGSSSNNTGSSTGNGAGGAGGGGGGNNAGGGGGNNSSTDGLHRNGGGNGNCHEAGIGSLQNSADSKLCFDSGTHPSSTADALIEPLRVSPMIRDFVQSIDDREWQTQLFALLQKQTYNQVEVDLFELMCKVLDQNLFSQVDWARNTVFFKDLKVDDQMKLLQHSWSDMLVLDHLHHRIHNGLPDETQLNNGQVFNLLSLGLLGVPQLSDYFNEIQNKLQDLKFDMGDYVCMKFLILLNPTVRGIVNRKTVSEGHDNVQAALLDYTLTCYPSVNDKFSRLVNILPDIHAMAARGEEHLYIKHCAGSAPTQTLLMEMLHAKRKV*

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00581562;
90% Identity: iTF_00471643;
80% Identity: iTF_00580790;