Dosh012860.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Drosophila oshimai
Gene Symbol
Lztr1
Assembly
GCA_018150695.1
Location
JAECWM010000001.1:139091-142388[+]

Transcription Factor Domain

TF Family
BTB
Domain
zf-C2H2|ZBTB
PFAM
PF00651
TF Group
Zinc-Coordinating Group
Description
The BTB (for BR-C, ttk and bab) [6] or POZ (for Pox virus and Zinc finger) [1] domain is present near the N-terminus of a fraction of zinc finger (Pfam:PF00096) proteins and in proteins that contain the Pfam:PF01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerisation and in some instances heteromeric dimerisation [1]. The structure of the dimerised PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule [2]. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT [5, 3, 4]. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 3 3e-13 8.2e-11 42.0 0.2 1 108 567 708 567 710 0.88
2 3 0.57 1.6e+02 2.5 0.1 78 108 710 740 705 742 0.89
3 3 2.6e-19 7.3e-17 61.5 0.0 8 104 801 899 795 905 0.85

Sequence Information

Coding Sequence
ATGCTAAAGTCGATCAGCGGCGGCGTTGGCGTGGCATCCACGGACAGAGGAGGCGGTGGTGGTGGAGGGAGCGGGAGTGCCGGGGGCGGAGCGAGCGGAACTGGAAGTGTCTCTGGCAGCAGGAGCGCCAGCGGAAGTGGGCGTGCCAGCTGTGGGCTGGGTTCCAGTTCGATCTCCAGCGGACTGAGTGCGGTGTGCGGATTCGTGACCGGCGGAGGGGACAAGGACAGAGACAGGGAGAGGGACAGAGACAGAGGAGCAGCTAGCAGCAGTGGCGGCAGCACACCCGCCGGAGTCCTCTACTGCCCCGCCTGCGTGGCAGCCGCCAACCAGCAGAACCCCAGCCAGAACTCCAGTCCCCAGCACGAGGGCTTCTTCTCGCGCAGCTCCTCCAAGTCGAGCAAGCGGAACAAGGCCAGGAAAAGTGCCTCCACCGCCGGCTGCCTGGACGCCCAGCACATTCGCGCGAACCTTCGGATGTCCATGTCCAGCTCCATGAGGAGCACTAGGAGCGGCGCACCAGGAGCGGCCTCCTCGCATGCGCCGGGAAGCGTCTGCAGCGGAGCAGGCGGACCGGGCGGAACGGGGTGCGCACTGGCCTACGACGCGGCCAGCAACGCCAGCAGTGGCAGTGGCAGCGGCAAGGCGGCTTCTCCGGGCAGCTACAGCTGCAACGCCCTGAACGTGGACTTCACCTCCTACACTGCCACGCACCAATGGACCAGGATGCTGGAGTGCGCCGAGTTCGTGGGAGCCAAGCGGAGCAAGCACACTGTGGTGGCCTACAAGGATGCGATGTTTGTGTTCGGCGGCGACAACGGCAAAAACATGCTCAACGACCTGATCCGCTTCGGCGTGAAGGACAAGTCCTGGGGCCGGGCTTGTGCCACGGGAACACCGCCGGCTCCGCGGTACCACCACTCGGCGGTGGTGGCCGGCAGCTCGATGTTCATTTTCGGCGGCTACACCGGCGACATCCACTCCAACTCGAACCTGACCAACAAGAACGATCTGTTTGAGTACAAGTTTCAGAGCGCCATGTGGGTGGAGTGGAAGTTCTCCGGGCGCCAGCCGGTTCCACGGTCCGCCCATGGAGCGGCCGTGTACGACAACAAGATGTGGATCTATGCGGGTTACGACGGCAACGCCAGGCTGAACGACATGTGGACCCTGAATCTCACCGGGGAGAACCACCAGTGGGAGGAGGTGGACCAGCAGGGCGATCGCCCGCCCACCTGCTGCAATTTCCCCGTGGCGGTGGCCAGAGATGCCATGTACGTGTTCTCCGGACAGAGTGGCCTGCAGATCACGAACTCCCTGTTTGAGTTCCACTTCAAAACCCGCACCTGGCGGCGTATTTCCAACGAGCCAGTCCTGAGAGGAGCCACTTCAGCACCCCCCTCGCGCAGATATGGACACACCATGGTGCACCACGACCGCTTCTTGTATGTGTTCGGGGGCTCAGCGGACTCCACGCTGCCAAACGATCTCCACTGCTACGACCTGGACTCGCAAGTGTGGTCCGTCATCCTGCCGGAACAGAACTCCGATGTGCCCTCGGGCAGGGTTTTCCACGCCTCTGCCGTGATCTGCGACGCCATGTACATTTTCGGAGGCACCGTGGACAACAGCGTGAGGCGAGGCGACACCTACCGTTTCCAGTTCTCCTCCTACCCGAAGTGCACGCTGCGCGACGACTTTGGTAAGTTCTTTCAGGAGAAGCAGTTCTGCGACATTCAGTTCATCGTGGGGTCGGAGGAAATACGTATCCTTGCCCACATCGCCTTTGTGGCTGCGCGGTCCAAGTACTTGCGGAACAAAATCCTGGCGGCCCGGGAGGCACGCCAGCAGCAGATGGAGAAGGTCTACGGGGTGGGCCAGGTGGATGCACAGGCTCTGAATACGGGCGCGGGCGGGGACCGCGGACCCATGCTAGAGGTGCGCCTGGCTCATGCCTCCCCCGAGGCCTTCGACATCATATTAAACTACATTTATACCGACCGCATCGATCTGAAGGACACGTACAGCAAAAACATCATCATTCTCATCACGGACATCTACCAACTGGCGGGTCTGTTTACCATGCCGCGGCTGGCCCACGGCTGTATTCAGTATTTAGACTACAAGATCAACAAGCTCAACGTGCTGGAGGCACTCTACAACGCGGACAAAAGCAACATTAAGATCATCAAAGATCACTGCATGCAGTTTATCATCAAGGAGGAGAACTTCACGGAGGTGGTTATGTCCAGTGAGTTCAGCGACTTGGACAAGCCCCTGCTGGTGGAAATCATACGCAAGCGGCTGCATCCCAGCAAGCTGGTGATGGACACTAGCTATGAGGCCAATATAGGGACCACCCTGGAGATCGACCTGTGTGCCTTCTTGGAGTCAACTGGGAACGATTTCTGCGACATAAGCCTTATCCTGGAGGATCATGTGATACCGGCCCATAAGTCGGTGTTATCATCACGCTGTACCTACTTTCAGGGCATGTTCCGCTCGTTCATGCCGCCGGATAACACCGTCAATATCCAAATTGGCGAAATATCACCCTCGCTTGAGGCGTTCCACTCCCTGCTGCGCTACATCTACTACGGCGAGACGAAGATGCCTCCGCAGGACGCTCTGTACCTGTTCCAGGCGCCCTGTTTCTACGGACTGGCCAACAACAGGCTGCACGCGTTCTGCAAGTACTCGCTGGAGCACAACATCACGTTCGAGAATGTGCTGCAGACGCTGGAGGCGTCGGACATCACCAAGATCTATGACATCAAGGAGTACGCTCTGAAGCTGATCGTCAAAGATTTTGCGAAGGTGGCCCGGCTGCCGAAGATAGCGGGTTTGTCGCGCGAACTGTTGCTGGAGATCATACGCGCTGTGGCCGATTCGCACGGCGAGTTCCTGACGCGGATCAATATCAATACAGATATCTGA
Protein Sequence
MLKSISGGVGVASTDRGGGGGGGSGSAGGGASGTGSVSGSRSASGSGRASCGLGSSSISSGLSAVCGFVTGGGDKDRDRERDRDRGAASSSGGSTPAGVLYCPACVAAANQQNPSQNSSPQHEGFFSRSSSKSSKRNKARKSASTAGCLDAQHIRANLRMSMSSSMRSTRSGAPGAASSHAPGSVCSGAGGPGGTGCALAYDAASNASSGSGSGKAASPGSYSCNALNVDFTSYTATHQWTRMLECAEFVGAKRSKHTVVAYKDAMFVFGGDNGKNMLNDLIRFGVKDKSWGRACATGTPPAPRYHHSAVVAGSSMFIFGGYTGDIHSNSNLTNKNDLFEYKFQSAMWVEWKFSGRQPVPRSAHGAAVYDNKMWIYAGYDGNARLNDMWTLNLTGENHQWEEVDQQGDRPPTCCNFPVAVARDAMYVFSGQSGLQITNSLFEFHFKTRTWRRISNEPVLRGATSAPPSRRYGHTMVHHDRFLYVFGGSADSTLPNDLHCYDLDSQVWSVILPEQNSDVPSGRVFHASAVICDAMYIFGGTVDNSVRRGDTYRFQFSSYPKCTLRDDFGKFFQEKQFCDIQFIVGSEEIRILAHIAFVAARSKYLRNKILAAREARQQQMEKVYGVGQVDAQALNTGAGGDRGPMLEVRLAHASPEAFDIILNYIYTDRIDLKDTYSKNIIILITDIYQLAGLFTMPRLAHGCIQYLDYKINKLNVLEALYNADKSNIKIIKDHCMQFIIKEENFTEVVMSSEFSDLDKPLLVEIIRKRLHPSKLVMDTSYEANIGTTLEIDLCAFLESTGNDFCDISLILEDHVIPAHKSVLSSRCTYFQGMFRSFMPPDNTVNIQIGEISPSLEAFHSLLRYIYYGETKMPPQDALYLFQAPCFYGLANNRLHAFCKYSLEHNITFENVLQTLEASDITKIYDIKEYALKLIVKDFAKVARLPKIAGLSRELLLEIIRAVADSHGEFLTRININTDI