Basic Information

Insect: Drosophila ochracea
Gene Symbol: egg_1
Assembly: GCA_035044125.1
Location: JAWNML010000050.1:932316-937489[-]

Transcription Factor Domain

TF Family: MBD
Domain: MBD domain
PFAM: PF01429
TF Group: Unclassified Structure
Description: The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 1 1.8e-13 2.7e-10 39.6 0.0 5 75 1009 1072 1006 1074 0.90

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	1	1.8e-13	2.7e-10	39.6	0.0	5	75	1009	1072	1006	1074	0.90

Sequence Information

Coding Sequence: ATGAAGTTTGTGATTGTCCTCGCATGCCTTTTGGCCGTTGCTTACGCTAATGATGCCATTGTCCTTAAGGAATACAACGAAGTCAATCCTGACGGCTACAAATATGAGCTGGAAACTTCCGAAGGCATCAAAACTTCACAATCGGGACAACTGAAGGATCCGAAGACACTTGAGGTTCATGGATCATACGAATACTTATCGAAGGAAGGAAAACCCGTCAAGGTTACCTACACTGCTGATGAGCTTGGTTTCCATCCCAAGCACGAAGATGCGACATCGGTTGACACCTTGGCCAAACCAGCTGCAAGTGAATTGGCTTTGCCGGTAACGGAGACAGCCGCTGAGGAAAAAACTATCACAATGGAGATGGAGCAGGAGAAGGTCGAGGAGGAGAAATTGACTTCTGTCGAAGAACCTATGGAATTAGATGATGTACTTTCTGATCCGTCGATAGTGCCAGACTCTGAGAATAACATTGACCCATCCACTTGTGAAAGTAAAATAGATGAAAATAACCTCTTTGCCGCAGATGCGGATGCTCCCGAGTTAGAAAAAAGTATCAGCGAATTAACAGCAATGGAAAATTCCAAAGAAGATACAGACTGTTCAATAGAAAAACTTAATTCAGATAAGCCAATCGAAACTGATTTGGACAGCAGCATTGAACTAATCAGTAGTCCCATTATCGATGAAACTGGTCCTGCTGACAAGGAAAAGGAGGTGACTGAAACTACAAGTACAACAGATAACACTGGTTCACTCAAACCAAACGAAACCGATTTGGATAGCAGCATTGAGCTGATTGAGAGTCCCGCTATGGAAGAGTTGCCCAATAAGGAGAGTTCGAAGGATACTACAGTGGATAGCGACAGCAGCATTGAGTTGATTAGTAGTCCTGACAAAGATATAGACGATGCCAACAAAAACGTGTCCAATGAAGAAGCACAATCTAATGTGGAAGATGAGGAACAATCAAAAAGCATATCCCATGACAACGACGTATATGACGAGAAAaagcaaattcaaaacaaagaCATCACAGAAGCCAAATCAATTGATATGGAAGAAGCGAAGACCACAAGTCCATCGGATGAAGCCACTCCTTCAAAAGCCATAATCGAAGAATTTTCTCACACTTCCCCCGCATCCGCAGAAGACATTAACACAGAAGAACAAGAGATGCCAGATAATGCAGCAAACTCTGTGGCCAATGAAGAACCACAAAATTCGGAGTCTGTAGAAGTAGATGAGCTGCCCAAGACTAACGAAAACAGTTGTCTAGTCGAGCTAAACACCGACGGTGACACGAAAGAAAACCTCGAATATGAAACGGATACTGAAATCTATTACAAGAAGGACTGCCTCAATTGCAACTGCCAGAAGATGCATAAGCAGTACATGCTGGCGACCCTGGCAGCGCTCAACTACTATAAGGTGCCTAGAAAGGCACACAAGCGACAATACATCTGCGTGGGTTGCTATGACACAGCAATGGATATGTACGAGGACTTTGCTGGTTTCCTACTGGCCAAGCAGCCTCTGCTATTGCGGAACTTCAAGCAGGAACATGCAGACTTTGTGGCTCTGGACAGCAGTGACGAGGAGGAAAACTGTATAGAGCAGGAAAAATCAGAATTTTCGTCAAATGATTTGCAACTGATTGAAGATGAACTGGAGGATGCCATCAAAACTGTTATGGGCAGAGTAGAGATAGAGGACCAGATGGCTTGGTCCAAGACTATATTACAATCAAAAACACAGCGCATAGGGCGCGAAATCGAGTTGGCCAACCAAGAGCTGAGCAAGCTACAGAATATGGCtgacaaaatgcatttcgcCCTGTACAGCTCGTGCCAAGTGGTGCACAAGCACATGCCTGCACTTGACCTCTACCAAAATATGCTCGATTATGTGCAAGTGCCACCAGCGGGAGAGATCGAGCGACCCCCGATTCAATTGAACGAGACCTACTACGCTGTGAAGAACAAAGCCATTGCCAGCTGGGTCTCGGTCAAAGTGATCGAGTTTACAGAGAGTTCAACAGTGGGCGGCATTATGGTAAAGAGCTATAAGATCAAGTATCTTAATACGCCATATCAAATGGTTAAAACGATAACAGCCAAGCATCTAGCCTACTTCGAGCCGCCGCCAGTTCGCTTAACTATTGGCTCTCGCGTCATAGCCTATTTTAATGGCAGCACGTTATCGCGCGGCAAGGAGAAATGCGTCGTACCCAGCGCATTCTATCCGGGCATTATAGCCGAGCCACTGAAACAGGCCAATCGCTTTAGGTATTTAATCTTCTATGATGATGGCTACACACAGTATGTGCAGCACAGCGATGTGCGTTTGGTTTGTCTGGCATCGGAGAAAGTATGGGAGGATGTGCATCCCGGCTCGCGAGactttatacaaaaatatgtggaAAAATACTCAGTGGATCGACCAATGGTGCAATGCACACGTGGCCAAAACATGAACACCGAATCCAACGGCACCTGGCTGTATGCACGCGTCATTGACATTGACTGCAGCCTGGTGCAGATGCAATTCGATGATGACAAGAATCACACCGAATGGATCTATCGTGGCTCCCTGCGCTTGGGGCCAGTATTCAAGGAGACGCAAAATGCGCTCAACAGCGCCAATGCCATGCAACAGCATCGTGTGCCGCGCCGCACCGAACCCTTCATACGCTACACTAAGGAGATGGAGACGAGCAGCAGACAGGTGAACCAGCAAATGCGTGCAATTGCGCGCAAGAGCAGCTCCGTGCCACAGAACGTTAAtacgtcatcgtcatcctctgctgctgcggcagctgccaatgctgctgctgctgcagcaacgcGCAACGCAGTTCGCCATTTGAACAACTCAACCATCTACGTAGACGATGAGAACCGGCCCAAGGGTCATGTTGTCTACTTTACGGCCAAGCGGAATCTGCCGCCCAAAATGTACTCGCCCCACGAATGCAGTCCAGCCTGTTTGTTCAAGATTGTGCATCGCCTGGATAGCTACAGTCCGTTGGCTAAGCCGCTGCTTTCCGGTTGGGAACGCTTGGTGTTCAAGCAGAAGGCAAAGCGTAATGTGGTCTATCGTGGACCTTGTGGCAAGAGTTTTCGTAATCTGGCCGAAGTGCACATGTATCTGCGTGCCACGGACaatgttttaaatgttgaaaactTTGATTTTACGCCGGACTTGCGCTGCCTGGCAGAGTACTCTATTGATCCAACTATTGTTAAGGAGGCGGACATATCGAAGGGTCAAGAGAAAATGGCCATACCACTGGTAAACTACTATGACAACACATTGCCGCCGCCCTGCACCTATGCCAAGCAGCGCATACCCACAGAGGGAGTGCATCTGAATCTCGACGAGGAATTTCTGGTGGGCTGTGACTGCGAGGATGATTGCTCGgaCAAATCAAAATGCGCCTGTTGGCAGCTAACTGTTGGGGGTGTCAGGTACTGCAATCCCAACAAACCCATAGAGGAGATCGGCTATCAATACAAGCGTCTTCACGAGCATGTTCCCACCGGCATCTACGAATGCAACTCCCGATGCAAGTGCAAAAAGAACTGCCTAAATCGAGTGGTTCAGCATTCGCTGGAAATGAAGCTACAGGTCTTCAAGACTTCGAATCGGGGCTGGGGTCTGCGATGCGTCAACGATATACCAAAGGGTGCATTCATTTGCATCTATGCGGGGCACTTGCTCACGGAAACGATGGCCAACGAGGGTGGATTGGATGCGGGTGATGAGTACTTTGCCGACTTGGATTACATTGAGGTGGCCGAGCAACTTAAGGAGGGCTATGAATCGGATGTTGAACACTCGCCAGCGGAGGAGGAAGAAGACACCTACGCCCCAGATCCGGAGGACGATGCTGACTTCACACCCACCAAGTATTATCAGCCGCGCAAAAAGGATAAGCTGCGTGCATCGCGAAGCCACTCGAACAATTCAAATGAACCGGATTCGCAGGAGCGAGCAGTTATAAACTTCAATCCCAATGCCGATCTGGATGAAACAGTGCGCGAGAATTCAGTGCGTCGGCTCTTCGGCAAAGACGAGGCGCCCTACATTATGGACGCAAagacaactggcaacttggGTCGTTACTTTAATCATTCTTGTGCACCCAATTTGTTCGTGCAGAACGTGTTTGTGGACACACATGATCTTCGATTTCCCTGGGTCGCGTTCTTCTCGGCAAACCATATACGGTCCGGGACAGAGCTGACATGGAACTATAACTACGAGGTGGGCGTGGTGCCCGGCAAAGTTCTCTATTGTCAATGTGGAGCCACCAATTGTCGAATACGTTTACTTTAA
Protein Sequence: MKFVIVLACLLAVAYANDAIVLKEYNEVNPDGYKYELETSEGIKTSQSGQLKDPKTLEVHGSYEYLSKEGKPVKVTYTADELGFHPKHEDATSVDTLAKPAASELALPVTETAAEEKTITMEMEQEKVEEEKLTSVEEPMELDDVLSDPSIVPDSENNIDPSTCESKIDENNLFAADADAPELEKSISELTAMENSKEDTDCSIEKLNSDKPIETDLDSSIELISSPIIDETGPADKEKEVTETTSTTDNTGSLKPNETDLDSSIELIESPAMEELPNKESSKDTTVDSDSSIELISSPDKDIDDANKNVSNEEAQSNVEDEEQSKSISHDNDVYDEKKQIQNKDITEAKSIDMEEAKTTSPSDEATPSKAIIEEFSHTSPASAEDINTEEQEMPDNAANSVANEEPQNSESVEVDELPKTNENSCLVELNTDGDTKENLEYETDTEIYYKKDCLNCNCQKMHKQYMLATLAALNYYKVPRKAHKRQYICVGCYDTAMDMYEDFAGFLLAKQPLLLRNFKQEHADFVALDSSDEEENCIEQEKSEFSSNDLQLIEDELEDAIKTVMGRVEIEDQMAWSKTILQSKTQRIGREIELANQELSKLQNMADKMHFALYSSCQVVHKHMPALDLYQNMLDYVQVPPAGEIERPPIQLNETYYAVKNKAIASWVSVKVIEFTESSTVGGIMVKSYKIKYLNTPYQMVKTITAKHLAYFEPPPVRLTIGSRVIAYFNGSTLSRGKEKCVVPSAFYPGIIAEPLKQANRFRYLIFYDDGYTQYVQHSDVRLVCLASEKVWEDVHPGSRDFIQKYVEKYSVDRPMVQCTRGQNMNTESNGTWLYARVIDIDCSLVQMQFDDDKNHTEWIYRGSLRLGPVFKETQNALNSANAMQQHRVPRRTEPFIRYTKEMETSSRQVNQQMRAIARKSSSVPQNVNTSSSSSAAAAAANAAAAAATRNAVRHLNNSTIYVDDENRPKGHVVYFTAKRNLPPKMYSPHECSPACLFKIVHRLDSYSPLAKPLLSGWERLVFKQKAKRNVVYRGPCGKSFRNLAEVHMYLRATDNVLNVENFDFTPDLRCLAEYSIDPTIVKEADISKGQEKMAIPLVNYYDNTLPPPCTYAKQRIPTEGVHLNLDEEFLVGCDCEDDCSDKSKCACWQLTVGGVRYCNPNKPIEEIGYQYKRLHEHVPTGIYECNSRCKCKKNCLNRVVQHSLEMKLQVFKTSNRGWGLRCVNDIPKGAFICIYAGHLLTETMANEGGLDAGDEYFADLDYIEVAEQLKEGYESDVEHSPAEEEEDTYAPDPEDDADFTPTKYYQPRKKDKLRASRSHSNNSNEPDSQERAVINFNPNADLDETVRENSVRRLFGKDEAPYIMDAKTTGNLGRYFNHSCAPNLFVQNVFVDTHDLRFPWVAFFSANHIRSGTELTWNYNYEVGVVPGKVLYCQCGATNCRIRLL

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00518434; iTF_00595938; iTF_00501798; iTF_00553032; iTF_00582952; iTF_00570389; iTF_00516983; iTF_00499579; iTF_00514171; iTF_00485854; iTF_00598878; iTF_00577055; iTF_00542433; iTF_00525122; iTF_00498147; iTF_00513452; iTF_00557206; iTF_00497380; iTF_00566786; iTF_00528041; iTF_00560265; iTF_00482227; iTF_00607059; iTF_00619833; iTF_00495106; iTF_00521347; iTF_00609878; iTF_00558656; iTF_00593094; iTF_00597355; iTF_00496593; iTF_00574043; iTF_00511270; iTF_00535305; iTF_00535306; iTF_00552299; iTF_00500304; iTF_00498869; iTF_00543739; iTF_00508328; iTF_00538223; iTF_00522169;
90% Identity: iTF_00518434; iTF_00595938; iTF_00501798; iTF_00553032; iTF_00582952; iTF_00570389; iTF_00516983; iTF_00499579; iTF_00514171; iTF_00485854; iTF_00598878; iTF_00577055; iTF_00542433; iTF_00498147; iTF_00557206; iTF_00576341; iTF_00513452;
80% Identity: -