Basic Information

Insect: Drosophila nigritarsus
Gene Symbol: egg
Assembly: GCA_035044305.1
Location: JAWNMF010000166.1:1345153-1349713[+]

Transcription Factor Domain

TF Family: MBD
Domain: MBD domain
PFAM: PF01429
TF Group: Unclassified Structure
Description: The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 1 1.2e-13 3e-10 39.7 0.0 5 75 933 996 930 998 0.90

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	1	1.2e-13	3e-10	39.7	0.0	5	75	933	996	930	998	0.90

Sequence Information

Coding Sequence: atgGCCGCGGAATCTGCGACATCGGTTGACGCCTTGGCCAAATCAGCTGCAAGTGAATTGGCTTTGCCGGCAACGAAGACAGCCGCTGAGGCAAAAACTATCACAATGGAGATGGAGAACGAGAAGGTCGAGGAGGAGAAACTTACTGCTTGCGAAGATCCTATGGAATTAGATGATATTCCGGTTGATCCGTCGATAGTGTCAGATTCTGAGAAGAACAGTGAACCATCCAccagtaaaagtaaaaaacgtGAAAATAAAGAATCGAAAGCGAACGTCTTTACCGCAGATGCGGATGCTCCCGACTTAGAAAAAAGTATTAGCGAAATAAAAGCAATGGAAAATTCTAAAGAAGATTCGGACTCTTCAATAGAAAAACTTAATTCAGATAAGCCAATCGAAACTGATTTGGACAGCAGCATCGAACTAATCAGTAGTCCCATTATCGATGAAACTGGTCCTGCTGACAAGGATAAGGAGGTAACTGAAACTGCAAGTACAAAAAAAGTCGCAGGTTCTACAACAGATAAAGCTGATTCACTCAAACCAAACGAAGCCGATTTGGATAGCAGTATTGAACTGATTGAGAGTCCCGCGGTGGAAGATTTGCCCTATAAGGAGAATTTGAAGGATAGTACAGTGGATAGCGACAGCAGCGTTGAGTTGATTAGCAGTCCTGACAAAGATATTGACGATGCCAACAAAGACGTGTCCAATGAAGAAGCACGATCTAATTTGGAAGATGAACATTCAAAAAGCACACCCCATGACAATGATGTAGATGACGAGaaaaagcaaattcaaaacGAAGACATCACAGAAGCCATATCAATGGATACGGAAGAAGCGAAAACCACAAGTCAATCGGATGTACCCACTACTTCAAAAACCATAATTGACGAATTTTCTCACACTTCCCCCAAATCCTCAGCAGAATTTCACACAGAAGAACAAGAGATGACAGATAATGCAGCAAAGTCTGAGATGCATGAAGAACGAGAAAGTTCGGAGCCTATGGAAGTAGATGAGCTGCCCAAGAATAACGAAAACAGTTGCCTAGTTGAGCTAAACACCGACGGTGACTCGAAAGAAAATCTCGAATTTGAAACGGATTCTGAAATCTACTACAAAAAGGACTGCCTCAATTGCAACTGCCAGAAGATGCATAAGCAGTACATGCTGGCGAGCCTGGCAGCGCTCAACTACTACAAGGTGCCCAGAAAGGCACACAAGCGACAATATATTTGCATGGGCTGCTATGACACAGCAATGGATATGTACCAGGACTTTACTGGTTTCCTAGTGGCCAAACAGCCTCTGCTGTTGCGTAACTTCAAGCAGGAGCACGCAGACTTTGTGGCTCTGGACAGCAGTGACGAAGAGGAAAATTGTCAAGAGCAGGACAAATCCGAATTTTCGTCAAACGATTTGCAACTGATTGATGATGAACTAGAGGATGCTATCAAGACTGTTATGGGCAGAGTGGAGCTGGACGACCAGATGGCTTGGTCCAAGACTATATTACAATCAAAAACACAGCGTATAGGGCGCGAATTCGAATTGGCCAACCAAGAGCTAAGCAAACTACAGAATATGGCtgacaaaatgcattttgcccTGTACAGCTCCTGCCAAGTGGTGCACAAACACATGCCTGCGCTTGACCTCTACCATAATTTTCCCGATTATGTGCAAGTGCCACCGGCGGGTGAGATCGAGCGACCTCCGATTCAACTAAACGAGACCTACTACGCTGTGAAGAACAAAGCAATTGCCAGCTGGGTGTCGGTCAAAGTGGTCGAGTTTACAGAGAGTTCAACAGTGGGCGGCATCATGGTAAAAAGCTACAAGATCAAGTATCTCAATACACCATATCAAATGGTTAAAACTATAACAGCCAAACATTTAGCCTACTTTGAGCCGCCGCCAGTCCGTTTAACTATTGGCACTCGCGTCATAGCCTACTTTAATAACAGCACTTTGTCGCGCGGCAAGGAGAAGTGCGTCGTACCCAGCGCATTCTATCCGGGCATTATAGCCGAGCCTCTGAAACAGACCAATAGCTTTAGGTATTTAATCTTCTATGATGATGGCTACACACAGTATGTGCATCACAGCGATGTGCGTTTGGTTTGTCTGGCATCGGAGAAAGTATGGGAGGATGTGCATCCCGGCTCGCGAGACTTTATACAAAAGTATGTGGAAAAATACTCAGTGGACCGACCAATGGTGCAATGCACACGCGGCCAAAACATGAACACCGAATCCAACGGCACCTGGCTGTATGCGCGCGTGATTGACATTGATTGCAGTCTGGTGCAGATGCAATTCGATGATGAAAAGAATCACACAGAGTGGATCTATCGTGGCTCCCTGCGTCTGGGTCCAGTATTCAAGGAGACACAAAATGCGCTTAACAGCGCCAATGCCGTGCAACAGCATCGTATGCCGCGCCGCACCGAACCCTTCATACGCTACACTAATGAGATGGAGACGACCACCATTTACCAGCAAATGCGTGCAATTGCGCGTAAGAGCAGCTCCATGCCACAGAACGTTAACACGTCACCCTCAtcctctgctgctgcggcagctgccaatgctgctgctgctgcagcagctcgcAACACCGTTCGCCATTTGAACAACTCAACCATCTACGTAGACGATGAGAACCGGCCCAAGGGACATGTTGTCTACTTTACGGCAAAACGCAATTTGCCGCCCAAAATGTACTCGTACCACGAATGCAGCCCAGCCTGTTTGTTCAAGATTGTGCATCGCCTGGATAGCTACAGTCCGTTGGCTAAGCCGCTGCTTTCCGGCTGGGAGCGCTTGGTGTTCAAGCAGAAGGCAAAGCGCAATGTCGTCTACCGCGGACCTTGTGGCAAGAGTTTTCGCAATCTAGCCGAAGTGCACATGTATCTGCGTGCCACGGATAATGTTTTAAACGTTGAAAACTTTGATTTTACGCCAGATCTGCGCTGCCTGGCAGAGTACTCTATTGATCCAACAATTGTTAAGGAGGCGGACATATCGAAGGGACAAGAGAAAATGGCCATACCTCTGGTAAACTACTATGACAACACATTGCCGCCGCCCTGCAACTATGCCAAGCAGCGCATACCCACAGATGGAGTGCATTTGAATCTCGACGAGGAGTTTCTGGTGGGCTGCGACTGCGAGGATGATTGCTCGGACAAATCCAAATGCGCCTGTTGGCAACTAACTGTTGGGGGTGTCAAATACTGCAACCCCAACAAGCCCATTGAGGAGATCGGCTACCAATATAAGCGTCTTCACGAGCATGTTCCCACCGGCATCTACGAATGTAACTCGCGGTGCAAGTGCAAAAAGAACTGCCTAAATCGAGTGGTTCAGCATTCGCTGGAAATGAAGCTGCAGGTCTTCAAGACATCGAATCGCGGCTGGGGTCTGCGATGCGTAAACGATATACCAAAGGGTGCATTCATTTGTATCTATGCGGGCCACTTACTCACCGAAACAATGGCCAACGAGGGAGGATTGGATGCAGGCGATGAGTACTTTGCCGACTTGGATTACATTGAGGTGGCCGAGCAACTGAAGGAGGGCTATGAATCGGATGTTGAACACTCGCCAGCGGAGGAGGAAGAAGACACCTACGCCCCAGATCCGGAGGACGATGCTGACTTCACACCCACCAAGTATTATCAGCCTCGCAAAAAGGATAAGCTGCGTGCATCGCGAAGCCActcaaataattcaaatgagCCGGATTCGCAGGAGCGCGcagttataaatttcaatCCCAATGCCGACCTGGATGAAACAGTGCGCGAGAACTCAGTGCGCCGGCTCTTTGGCAAAGGCGAGGCGCCCTACATTATGGATGCAAAGACAACTGGCAACTTGGGTCGTTACTTTAATCATTCTTGTTCACCCAATTTGTTTGTGCAGAATGTGTTTGTGGACACGCATGATCTTCGATTTCCCTGGGTCGCGTTCTTCTCGGTCATGCACATACGGTCCGGGACCGAACTGACTTGGAACTATAACTACGAGGTGGGCGTGGTGCCCGGCAAAGTTCTCTATTGTCAATGTGGAACCGCCAATTGTCGGGTGCGTTTACTTTAA
Protein Sequence: MAAESATSVDALAKSAASELALPATKTAAEAKTITMEMENEKVEEEKLTACEDPMELDDIPVDPSIVSDSEKNSEPSTSKSKKRENKESKANVFTADADAPDLEKSISEIKAMENSKEDSDSSIEKLNSDKPIETDLDSSIELISSPIIDETGPADKDKEVTETASTKKVAGSTTDKADSLKPNEADLDSSIELIESPAVEDLPYKENLKDSTVDSDSSVELISSPDKDIDDANKDVSNEEARSNLEDEHSKSTPHDNDVDDEKKQIQNEDITEAISMDTEEAKTTSQSDVPTTSKTIIDEFSHTSPKSSAEFHTEEQEMTDNAAKSEMHEERESSEPMEVDELPKNNENSCLVELNTDGDSKENLEFETDSEIYYKKDCLNCNCQKMHKQYMLASLAALNYYKVPRKAHKRQYICMGCYDTAMDMYQDFTGFLVAKQPLLLRNFKQEHADFVALDSSDEEENCQEQDKSEFSSNDLQLIDDELEDAIKTVMGRVELDDQMAWSKTILQSKTQRIGREFELANQELSKLQNMADKMHFALYSSCQVVHKHMPALDLYHNFPDYVQVPPAGEIERPPIQLNETYYAVKNKAIASWVSVKVVEFTESSTVGGIMVKSYKIKYLNTPYQMVKTITAKHLAYFEPPPVRLTIGTRVIAYFNNSTLSRGKEKCVVPSAFYPGIIAEPLKQTNSFRYLIFYDDGYTQYVHHSDVRLVCLASEKVWEDVHPGSRDFIQKYVEKYSVDRPMVQCTRGQNMNTESNGTWLYARVIDIDCSLVQMQFDDEKNHTEWIYRGSLRLGPVFKETQNALNSANAVQQHRMPRRTEPFIRYTNEMETTTIYQQMRAIARKSSSMPQNVNTSPSSSAAAAAANAAAAAAARNTVRHLNNSTIYVDDENRPKGHVVYFTAKRNLPPKMYSYHECSPACLFKIVHRLDSYSPLAKPLLSGWERLVFKQKAKRNVVYRGPCGKSFRNLAEVHMYLRATDNVLNVENFDFTPDLRCLAEYSIDPTIVKEADISKGQEKMAIPLVNYYDNTLPPPCNYAKQRIPTDGVHLNLDEEFLVGCDCEDDCSDKSKCACWQLTVGGVKYCNPNKPIEEIGYQYKRLHEHVPTGIYECNSRCKCKKNCLNRVVQHSLEMKLQVFKTSNRGWGLRCVNDIPKGAFICIYAGHLLTETMANEGGLDAGDEYFADLDYIEVAEQLKEGYESDVEHSPAEEEEDTYAPDPEDDADFTPTKYYQPRKKDKLRASRSHSNNSNEPDSQERAVINFNPNADLDETVRENSVRRLFGKGEAPYIMDAKTTGNLGRYFNHSCSPNLFVQNVFVDTHDLRFPWVAFFSVMHIRSGTELTWNYNYEVGVVPGKVLYCQCGTANCRVRLL

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00564645;
90% Identity: iTF_00482227;
80% Identity: -