Dobs014135.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Drosophila obscura
Gene Symbol
ftz-f1
Assembly
GCA_018151105.1
Location
NW:36500-83673[+]

Transcription Factor Domain

TF Family
SF-like
Domain
zf-C4|SF-like
PFAM
AnimalTFDB
TF Group
Zinc-Coordinating Group
Description
The ligand binding domain of nuclear receptor steroidogenic factor 1 (SF-1): SF-1, a member of the nuclear hormone receptor superfamily, is an essential regulator of endocrine development and function and is considered a master regulator of reproduction. Most nuclear receptors function as homodimer or heterodimers, however SF-1 binds to its target genes as a monomer, recognizing the variations of the DNA sequence motif, T/CCA AGGTCA. SF-1 functions cooperatively with other transcription factors to modulate gene expression. Phospholipids have been determined as potential ligands of SF-1. Like other members of the nuclear receptor (NR) superfamily of ligand-activated transcription factors, SF-1 has a central well conserved DNA binding domain (DBD), a variable N-terminal domain, a flexible hinge and a C-terminal ligand binding domain (LBD). [1, 8, 3, 11, 6, 5, 12, 10, 9, 2, 4, 7]
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 5 2 1.4e+04 -6.8 11.9 42 148 25 151 8 180 0.51
2 5 0.59 4.2e+03 -3.6 3.8 76 150 165 259 120 282 0.40
3 5 2 1.4e+04 -5.5 6.5 46 98 341 372 297 395 0.45
4 5 1.1e-19 7.9e-16 58.1 0.7 1 79 575 652 575 673 0.76
5 5 8.5e-71 6.1e-67 226.5 2.1 157 408 789 1033 774 1035 0.92

Sequence Information

Coding Sequence
ATGGACACCTTCAATGTACCTTTGCTGGCggagagcaccagcagcagcagcaattatGCGACAGCAGCAGTCACAGAGGCCTCAACCAGCAAcaaccatcatcatcacctgcagcatcagcagcagcaacatcttATGTCCCACCATCACAAGGATCAGATGCTGGCGGCGGGAAGTAGTCCCATGCTGCCGTTCCTCAGCTActctcagctgcagctgcagcagaaggaTAGtactgccagcagcagcagcaatggtgTAACTGCAGCATCTGAaggagcagaggcagcagcagcagcaattgccACAGATAACTTTGATGGCAGCCAATTGGATGGTGGCATCTCTCTGAGTGGCCTCTGCGAACGCTTCTTTGTGGCCAGTCCCAATCCTCATAGCAATAGTAACATGACCCTAATGGGCACCACCACtccaacaaccacaacaaccacCCAacacaacatcaacatcaacaacaataacaatttgGAGGCTAAAAACGGAACCATCCACACAGGTGCGGCAGCTCCCCAATCGCTGCAGAGAGGCGGTGGATCAGTCATCATCGAATCGGTGACGGTTCCCTCTTTTTCCAACATCCTGTTCTCCCATCGAAATTCTCAAGCCTCAACCAATGAATGCATCGATCCAGCACTGCTGCAGAAATCCACACTATCCAGCAGCTCGATCATAGAGTACCATCAGCTGAAACCCCTGGCAGCGAGTGCCACCAACTCGGCATCCGTTTCCACCACCAATTTCCTGTCCTCGAGCACCGCTCAGCTCTTGGATTTTGATGTGCAAGGCGCTTCCAAGGATGATAGCCATATAagcaccaccacaaccacagcAGGAGTGGGAATTGGTTCAGGATCGGGTTCGGGTACGAGCTCGGTATCCGGATCGGGTGTAGCAAcgacaacaagaacaacaatcaCTGCCAATCAGACAAGAAGCTCGTTGCACAGCATCGAGGAATTGGCTGCCAGCTCCTGTGTTGCACCCAAAGCCACCCAATCACCCAATCCTAATGAGAATGGGAACGTGAACCACAGGTCTACCAGCAGTACAACgaatcagcaacagcagcagcagcagcatcacatGCAACAAAGTGGCAATCACAGTGGATCCAATCTCAGCTCCGATGATGAGTCTGTTTCGGAGGATGAGTTCGGGCTGGAAATCGACGATCACGGAGGCTACCAGGACACCACCTCCTCCCACTCACAGCAGAGTGGCGGTGGgggcggaggcggtggcggagcTGGCGGCAACATCCTCAACGGCAGCTCGGGCAGTAGCTCCGGCTACATGCTGCTGCCCCAAGCGGCCAGCTCCAGCGGCAACACCAATGCCGCCCACATGTCCTCCGCCAGCGGATCTGTTGGCAATGCCAGCGGCCCCAACGGTGGCGGAGGCGGTTCCGGCCCTGGCAATGCCATGGGCGGTACGAGCGCCACTCCGGGACACGGCGGCGAAGTGATCGACTTCAAGCACCTCTTCGAGGAGCTATGCCCCGTGTGCGGCGACAAAGTCAGTGGCTACCACTATGGCCTGCTCACCTGCGAGTCTTGCAAGGGCTTCTTCAAGCGGACGGTCCAGAACAAGAAGGTCTACACTTGCGTGGCGGAGCGGTCGTGCCACATTGACAAGACGCAGCGCAAACGGTGTCCCTACTGCCGCTTCCAGAAATGCCTGGAGGTAGGCATGAAGCTGGAGGCTGTTCGAGCGGACCGGATGCGGGGTGGCAGGAACAAGTTTGGACCCATGTACAAGCGGGATAGGGCGCGGAAGCTGCAGGTGATGCGCCAGCGGCAGATCGCCCTCCAGGCACTGCGCAACTCGATGGGGCCGGACATCAAGCCGACGCCGATCTCGCCGGGCTACCAGCAAGCATATCCAAATATGAACATTAAGCAGGAAATCCAAATACCTCAGGTATCCTCACTCACCCAATCGCCGGACTCGTCGCCCAgccccattgccattgctctGGGCCAGGTGAATGCCAGCACGGGCGGAGTGATAGCCACGGCCATTAATGCCGGTAACGGGGgcagtggtggcggcggcggcggtagCGGCCTGAACGGCCCCAGCTCCGTGGGCAATGGCAatagcagcaacggcagcagcagcaacaacaacaccggCAGCAGCACAGGCAACGGAGCAGGTGGCGCCGgcggaggaggcggcggcggtggtggcaaCAATgcgggcggcggcggcggcaataACAGCTCCACCGATGGCCTGCATCGCAACGGCGGCGGCAATGGCAACTGCCACGAAGCTGGAATAGGATCTCTGCAGAACTCGGCCGACTCGAAACTGTGcttcGATTCCGGCACTCATCCATCGAGCACTGCCGATGCGCTTATCGAGCCACTGAGAGTCTCACCGATGATACGAGAATTTGTGCAATCGATCGACGATCGGGAATGGCAGACGCAGCTGTTCGCGCTGCTGCAGAAGCAGACCTACAACCAGGTGGAGGTGGATCTCTTTGAGCTGATGTGCAAGGTGCTCGATCAGAATCTGTTCTCGCAGGTGGACTGGGCAAGGAACACGGTCTTCTTTAAGGATCTGAAGGTCGATGATCAAATGAAGCTGCTGCAACACTCCTGGTCGGACATGCTGGTCCTCGATCATCTGCACCATCGCATCCACAACGGGCTGCCCGATGAGACGCAGCTGAACAACGGCCAGGTCTTCAATCTACTCAGTCTGGGGCTGTTGGGCGTGCCGCAATTGTCCGACTATTTCAACGAGCTGCAGAATAAGCTGCAGGATCTGAAATTCGACATGGGCGACTATGTCTGCATGAAATTCCTAATACTTTTGAATCCAAATGTGCGAGGCATTGTCAACAGGAAGACCGTGTCCGAGGGACATGATAATGTGCAGGCAGCCCTGCTGGACTACACCCTCACCTGTTATCCTTCAGTCAATGACAAATTCAGTAGGCTAGTGAACATCTTACCGGAAATCCATGCCATGGCCGCACGCGGCGAGGAGCATCTCTACTCCAAGCACTGTGCCGGCAGTGCACCCACCCAGACGCTGCTCATGGAGATGCTGCACGCCAAGCGGAAGGTGTAG
Protein Sequence
MDTFNVPLLAESTSSSSNYATAAVTEASTSNNHHHHLQHQQQQHLMSHHHKDQMLAAGSSPMLPFLSYSQLQLQQKDSTASSSSNGVTAASEGAEAAAAAIATDNFDGSQLDGGISLSGLCERFFVASPNPHSNSNMTLMGTTTPTTTTTTQHNININNNNNLEAKNGTIHTGAAAPQSLQRGGGSVIIESVTVPSFSNILFSHRNSQASTNECIDPALLQKSTLSSSSIIEYHQLKPLAASATNSASVSTTNFLSSSTAQLLDFDVQGASKDDSHISTTTTTAGVGIGSGSGSGTSSVSGSGVATTTRTTITANQTRSSLHSIEELAASSCVAPKATQSPNPNENGNVNHRSTSSTTNQQQQQQQHHMQQSGNHSGSNLSSDDESVSEDEFGLEIDDHGGYQDTTSSHSQQSGGGGGGGGGAGGNILNGSSGSSSGYMLLPQAASSSGNTNAAHMSSASGSVGNASGPNGGGGGSGPGNAMGGTSATPGHGGEVIDFKHLFEELCPVCGDKVSGYHYGLLTCESCKGFFKRTVQNKKVYTCVAERSCHIDKTQRKRCPYCRFQKCLEVGMKLEAVRADRMRGGRNKFGPMYKRDRARKLQVMRQRQIALQALRNSMGPDIKPTPISPGYQQAYPNMNIKQEIQIPQVSSLTQSPDSSPSPIAIALGQVNASTGGVIATAINAGNGGSGGGGGGSGLNGPSSVGNGNSSNGSSSNNNTGSSTGNGAGGAGGGGGGGGGNNAGGGGGNNSSTDGLHRNGGGNGNCHEAGIGSLQNSADSKLCFDSGTHPSSTADALIEPLRVSPMIREFVQSIDDREWQTQLFALLQKQTYNQVEVDLFELMCKVLDQNLFSQVDWARNTVFFKDLKVDDQMKLLQHSWSDMLVLDHLHHRIHNGLPDETQLNNGQVFNLLSLGLLGVPQLSDYFNELQNKLQDLKFDMGDYVCMKFLILLNPNVRGIVNRKTVSEGHDNVQAALLDYTLTCYPSVNDKFSRLVNILPEIHAMAARGEEHLYSKHCAGSAPTQTLLMEMLHAKRKV

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00514941;
90% Identity
iTF_00563964; iTF_00601080; iTF_00601106; iTF_00574841; iTF_00574871; iTF_00514941; iTF_00514915;
80% Identity
iTF_00563964;