Basic Information

Gene Symbol
RREB1
Assembly
GCA_037075265.1
Location
JBAMCI010000107.1:4508672-4514620[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 13 0.0058 0.42 11.3 0.6 1 21 247 267 247 269 0.96
2 13 0.00033 0.024 15.2 0.2 1 23 279 301 279 301 0.98
3 13 8e-05 0.0057 17.2 7.3 1 23 307 329 307 329 0.98
4 13 0.044 3.2 8.5 0.8 2 20 550 568 550 570 0.93
5 13 0.0087 0.63 10.7 0.1 1 23 719 741 719 741 0.97
6 13 1.2e-05 0.00087 19.7 0.7 1 23 751 773 751 773 0.99
7 13 0.00082 0.059 14.0 2.0 1 23 779 802 779 802 0.97
8 13 0.0029 0.21 12.2 2.0 1 23 1053 1076 1053 1076 0.95
9 13 8.5e-05 0.0061 17.1 0.3 2 23 1399 1420 1398 1420 0.97
10 13 0.14 10 6.9 6.3 1 23 1426 1449 1426 1449 0.97
11 13 3.2 2.3e+02 2.7 4.2 1 23 1568 1591 1568 1591 0.88
12 13 0.0083 0.6 10.8 0.5 3 23 1654 1674 1652 1674 0.96
13 13 0.0013 0.095 13.3 4.8 1 23 1680 1702 1680 1702 0.99

Sequence Information

Coding Sequence
atgCTGgccacacagcagcaacagcaacaacagccccaacagcaacatacagcagcaacagcagcagcggcagcagtgaCTCTTGAGGATGCGGTCATGGAGCGACAGCGTCGTGACTCCAGCACCTCGGAGTCGTCGCTGGAGCATCTGGATCTGGGTCGCACGCCAAAgaagctgagcagcagcagcggtgcGCCGCAGCCGACGTCGACGCCGCACGTTGAGGTGGCGTCGCGAAAGCGCAAGatgcgacaacagcaacagcaagtcTTGTACTCTGACGAGGAGGacgaacaacagcagcagcagcaacagcaacagcaacaacagcagcagcaacagttgctggaACAGTCGGTGCATCGCATGCGCCACAAGCAGCGCCGCAGCGGCAATgcagtcgctgccgctgccagcgCCAGCATCGTCGTCGACTACAGCGTCGGCAGCGATGCCAGTTCGCTGCGCAAAAAGTTTCGCCTGAATcgcagcagcatcagcgcCCACAACGGCGACCTCTCCGAGTCGGGCTTCGTCGATGGCAGCGCGCACAGCGGCTATTTGCTCAGCGCCAGCAGTGCAGCGCAGTCGGCGACGGCAGCGacgcagcatcagcagcagcagcaacagcagcagcagcagccgggcTCGGGCAGCAGCTCGGGCGGCTCCTCGCCGCAAGGCCTGTGCCATTCGAGCGCCGAGTCCGGCATCGGCGCTGGCGACGAGCACATGAAATACGTCTGCCCCATCTGCGAGGTTGTCTCGGCCACGCCCCACGAGTTCACCAATCACATCCGATGCCACAACTATGCCAACGGCGACACCGAGAACTTCACCTGCCGCATTTGCTCCAAGGTACTGTCGTCCGCCTCCTCGCTGGACAGACACGTCCTGGTGCACACCGGGGAGCGCCCTTTCAACTGTCGCTATTGCCATTTGACCTTTACGACAAATGGAAACATGCATCGACACATGCGAACACAcaagcaacatcagcagcagcagcaacagcagcagcagcagcaacaacaacaacagcaaccccagacacaacagcaacagttgcagcaacagcaacaacagccacagcagcagcagcaacagttgcagcgaCATCAGCAACATGCGGCATCAAATGCTGTGGCTCAACGTGCCGAGAGCTATGAAAGCGATGCCAGTTGCTCCACGGATAtatccagcagcagcagcagtgcagccagcaacaacaacaacaacaacaacaacaacagtagccaagcgaacaacaacaacagccatgaggagcagcaactgctgctggcgtgcaagcagcaacagctgaaaaccaatatcaacaacaacaacatcatcgtGAGCGACGAGCGAGCGCTGGATAcagatggcgatggcgatgtcGATGGGGAGGCAGATGCAGATGGAGACGAGGCTGGCGATGCTGAGAGCGTGGATGTGACACAGATGATAACGAGCACGCCCGACGTGGCCACATTGCTGGCGACGTCGTCGGGCAACAGCAGCCCGAGAACGCCAGAGCACGAGTCGGAGGCCCAGTTGTCCAGCTGCCCCGCCTGCAATGCCGATGGGTTTGAAACGCAGGCCGCGCTGTACGTCCACCTGGAGGCGGAGCACGCCGATATACCCGCCAAGTGTCGCGAGTGCGAGGTGATCTTTGCCACGCAGCGTCAGCTGCAGGCGCACAGCTGTCGCGGCCTCCagttgccgccgctgctgggCGCCAGCTCCTCGCCGCTGCACAAGCAGGAGCCAGCGGAAGAGGAGGatgaggagcagcagctgcgccaGCATGAAGCTGAGGTGGAGGCTGACGAAGATGAGGAAGAGATGCGCCTGCAGGCGAACAGCGAGCGGGATGAGTTCTTTCAGCAACTGTATCTTAAGGGCAAATCGGGTGGCTCCTCGCTGCCCTCGCCCATCAAGCACGAGCCGTCGGAGCAGCGCCAGGATCTGGCTGACATCCAGAGCATTCTGCACATgaccagctccagctgcacgTCCAGTTTCCTGCGCAACTTCGAGCAGAACGTGAACACGCCATGCTCGAGCCAGTACAGTCTGGATGGACGCGATGGCGAGGAGGAGGCACAGGATGCCTTCACCAGCGAATTCCGACGCATGAAGCTGCGCGGCGAATTCCCCTGCAAACTGTGCTCCGCCGTCTTTCCCAATCTGCGCGCCCTCAAGGGCCACAATCGCGTCCACCTGGCGGCCGTGGGTGCCGCTGGGCCCTTTCGCTGCAACATGTGTCCCTATGCTGTGTGCGACAAGGCAGCGCTGGTGCGGCACATGCGCACCCACAACGGCGATCGTCCGTACGAGTGCGCCGTCTGCAACTACGCCTTCACCACGAAGGCCAACTGCGAGCGACACCTGCGCAATCGGCACGGCAAGACGAGCCGGGATGAGGTGAAGCGTGCGATCGTCTATCATCCGGCCGAGGATGCCAGCTGCGAGGATATCAAGCCAAAGATGGATCCGGATCTGTCGGAGCTCAGCTTTCGCTCGCTTAGTCCGTCGCCCTCGACGACCAATGTGGAGTCGAGCTCACAGCTGAAGCACATGTTGCTGGCAGAGCAGCccagcaaacagcagcagcaacagcagcagcagccaccacagcctCCCTTGAAGATTCAGGTGAAGAGCCTGGATCAGCTGGTGGAGAAGCCACTGGCACCTGCCATGGATCTCAGCATGGATGTGCTGGATCTAAGCAAGAAACCGCAGCGCGAGCATGACTTACtcttgcagcagcaacagcaacaacagcagcagcaacagcagcaacaacagcagcaacagcagcagcaacagttgctctTCAATCCAGGCGATGCTGCCACGCAGTatatgcagctgctgcgcaaTCTGATGCTGCAGCAATCGTCCGGCTTTCCGTTCTTTGGCCTGATGGCGCCAccgccagctgctgcagctgctgcactggAGAAGTCAGCGCCAGCAATAGCAGTgccagcgacaacagcagcagttgctgccgtACCGCCCCCTCTGGGCCTGCCTTTGGCAGGGTTGGGCGTGCCGGTGCCAGCGGCCGGACCCGTCAAGATGGTCATCAAGAACGGCGTGCTAATGCCCAAGCAGAAGCAGCGTCGCTACCGCACCGAGCGACCCTTCGCCTGCGAGCACTGCTCGGCCAGATTCACGCTGCGCTCCAACATGGAGCGGCACgtcaagcagcagcatccgCAGTTCTATGCGCAGCGACAGCGCAGCGGGCATCATGTGATGCGTGGGCGCGCGGCCAACTCGGGCGCAGcacaggcagcggcagcagcagcggcggcagcagcagccgcagcagcagctgccatgACAAATCTgcatcagcaacatcagcagcagcagcatcaacagcagcaacatgcgcCCATCTCGGAGCAGGTGAAATATGCGATCTTGGCGCAGCAGTTGAAGGCGCGCAAGGATACGGATTTGTTGCAGCAGGCGCTGGCACATGGCTCCAGCAGTGTCGTGGTCAATCCATTGCTGCACTTCggctacaacagcagcagcagcaacagcaatgtcaATGGCAGCAatcagccgcagcagcaacagttgcccgTGGATGACGATGAGCCGCCCAAGCTGATCATAGACGAGGATGATGAAGATGATTTCGATGACATagacgaggaggaggaggaggaggatgagGAAGAGTTAGACCAAgacgaacagcaacagctggaagagcaacaacagcagcaacacgaacagcagcaacatgcggAGCAAGTGCAGCCTATTGAAATTGATGCCAAAGatgagccagagccagagtcagctGAGGCAGCCAAACTGAAGCCAAGTGGCGAGCCAACGACAATGAAGACAATGATTGCCCAGGCCGAGTCGGTGGCCAAGTCCTTGAAGGAGGTGGCCAGCTCGCCGTTCAAGGATGAATCTCAGGACCTGGTGCCGGTGGCCAAGCTGGTGGACAATGCTACCAGCAATCAGGTGTCGTTCAACAGCTACTTTCGGCCCAGCGATGTGGCCAACCACATGGAGCAGAGCGACGAGGAGGGCCTCGTCGCCTCCGGCAGCGCCAGCGAAAGCAACAACTCCGGCACCGAGGAcgtcaccagcagcagcagctgcagtgaGCCGAAGAAGAAGTCCGCCTACAGCCTGGCGCCCAACCGTGTCAGCTGTCCGTACTGCCAGCGCATGTTCCCCTGGAGCAGCTCGCTGCGTCGCCACATCCTCACCCACACGGGCCAGAAGCCATTCAAGTGCTCCCACTGCCCGCTGCTGTTCACCACGAAGAGCAACTGCGACCGCCATCTGCTGCGCAAGCACGGCAACGTCGAGTCCGCCATGTCGGTCTATGTGCCCACCGAGGACGTCAGCGAGCCGATACCCGTGCCCAAGTCCGTCGAGGAGATCGAGCTGGAGGAGCAGCGCCGGCGCAAGGCGGCCGAAAAGGAGCGCCAGCTGGAGCTCGAGCGCGAACGCGAGCGTGAACGTGAACTGGAGCGGGAGCGTGAGCTGGAGCGCGagcgcaagcagcagcagctcatccaaCAGCTGACGGCAGCGGCTCAGCTCAGCCAGCAGATGGTGGCAGCGGCACAAGCGgctgccgccgcagcagccaccagcagcggcaacggcagcggcactGGCGCCGAGGCCAATGGCAGCGAGCTGCCCTACAAGTGTCACCTGTGCGAGTATTCGTTCGGCGAGCGGATGCAGTGCCTCGACCACATCAAGCAGCAGCATGCCCAGGAGTTCGctctgctgctggccaaaggcgCCATCGAAACGGAACAGGAgacagctgttgctgcctcagccgctgctgctgctgctgcagctgcctctgcctctgctgccgTCTCCGAGGATGAGTCCAGCGCCGGACGTAACTCCGGCAAATATCCGGACTACAGCAACCGCAAGGTGATCTGCGCCTTTTGCGTGCGTCGCTTCTGGTCCACGGAGGATCTGCGCCGTCATATGCGCACCCACTCGGGCGAGCGTCCGTTCCAGTGCGAGATCTGCTTGCGCAAGTTCACGCTGAAGCACAGCATGCTCCGGCACATGAAGAAGCACAGCGGACGTAGTCACAATGGCGAGCCGGGCGCCTCCGACTGCTCCGATGATGAGCAGATGGCAACGCCGCCAACGACACCAACGCCCACggccatgcccatgcccatgccaatgcccagcaacaacaacaacaacaacacttgccacaacaacaacaacaacaccaacaataacaataacaacaacaacaacaacaagagcttGCGTCTGCCCAAGCTGCACGAGCTGCTGGACAAGGCGAACGAGTGGCGCGTCAGTCGCCTCGGCGAGCACAAGGAGAACATTGCCGAATCCTCGACgcccacagcagcagcagccgctgtgggcgtggccagcgGTGATTTCCTGGGCAATCTGCTGGGCATCACCGACCAGGGCATACTCAACAAGCTGCTCAGCTCGCCCGACGAGGCGGCCAAATTGCTGGGCGTCGAGAAGTGA
Protein Sequence
MLATQQQQQQQPQQQHTAATAAAAAVTLEDAVMERQRRDSSTSESSLEHLDLGRTPKKLSSSSGAPQPTSTPHVEVASRKRKMRQQQQQVLYSDEEDEQQQQQQQQQQQQQQQQLLEQSVHRMRHKQRRSGNAVAAAASASIVVDYSVGSDASSLRKKFRLNRSSISAHNGDLSESGFVDGSAHSGYLLSASSAAQSATAATQHQQQQQQQQQQPGSGSSSGGSSPQGLCHSSAESGIGAGDEHMKYVCPICEVVSATPHEFTNHIRCHNYANGDTENFTCRICSKVLSSASSLDRHVLVHTGERPFNCRYCHLTFTTNGNMHRHMRTHKQHQQQQQQQQQQQQQQQQPQTQQQQLQQQQQQPQQQQQQLQRHQQHAASNAVAQRAESYESDASCSTDISSSSSSAASNNNNNNNNNSSQANNNNSHEEQQLLLACKQQQLKTNINNNNIIVSDERALDTDGDGDVDGEADADGDEAGDAESVDVTQMITSTPDVATLLATSSGNSSPRTPEHESEAQLSSCPACNADGFETQAALYVHLEAEHADIPAKCRECEVIFATQRQLQAHSCRGLQLPPLLGASSSPLHKQEPAEEEDEEQQLRQHEAEVEADEDEEEMRLQANSERDEFFQQLYLKGKSGGSSLPSPIKHEPSEQRQDLADIQSILHMTSSSCTSSFLRNFEQNVNTPCSSQYSLDGRDGEEEAQDAFTSEFRRMKLRGEFPCKLCSAVFPNLRALKGHNRVHLAAVGAAGPFRCNMCPYAVCDKAALVRHMRTHNGDRPYECAVCNYAFTTKANCERHLRNRHGKTSRDEVKRAIVYHPAEDASCEDIKPKMDPDLSELSFRSLSPSPSTTNVESSSQLKHMLLAEQPSKQQQQQQQQPPQPPLKIQVKSLDQLVEKPLAPAMDLSMDVLDLSKKPQREHDLLLQQQQQQQQQQQQQQQQQQQQQQLLFNPGDAATQYMQLLRNLMLQQSSGFPFFGLMAPPPAAAAAALEKSAPAIAVPATTAAVAAVPPPLGLPLAGLGVPVPAAGPVKMVIKNGVLMPKQKQRRYRTERPFACEHCSARFTLRSNMERHVKQQHPQFYAQRQRSGHHVMRGRAANSGAAQAAAAAAAAAAAAAAAAMTNLHQQHQQQQHQQQQHAPISEQVKYAILAQQLKARKDTDLLQQALAHGSSSVVVNPLLHFGYNSSSSNSNVNGSNQPQQQQLPVDDDEPPKLIIDEDDEDDFDDIDEEEEEEDEEELDQDEQQQLEEQQQQQHEQQQHAEQVQPIEIDAKDEPEPESAEAAKLKPSGEPTTMKTMIAQAESVAKSLKEVASSPFKDESQDLVPVAKLVDNATSNQVSFNSYFRPSDVANHMEQSDEEGLVASGSASESNNSGTEDVTSSSSCSEPKKKSAYSLAPNRVSCPYCQRMFPWSSSLRRHILTHTGQKPFKCSHCPLLFTTKSNCDRHLLRKHGNVESAMSVYVPTEDVSEPIPVPKSVEEIELEEQRRRKAAEKERQLELERERERERELERERELERERKQQQLIQQLTAAAQLSQQMVAAAQAAAAAAATSSGNGSGTGAEANGSELPYKCHLCEYSFGERMQCLDHIKQQHAQEFALLLAKGAIETEQETAVAASAAAAAAAAASASAAVSEDESSAGRNSGKYPDYSNRKVICAFCVRRFWSTEDLRRHMRTHSGERPFQCEICLRKFTLKHSMLRHMKKHSGRSHNGEPGASDCSDDEQMATPPTTPTPTAMPMPMPMPSNNNNNNTCHNNNNNTNNNNNNNNNNKSLRLPKLHELLDKANEWRVSRLGEHKENIAESSTPTAAAAAVGVASGDFLGNLLGITDQGILNKLLSSPDEAAKLLGVEK

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00512904;
90% Identity
iTF_00532572; iTF_00573504;
80% Identity
-