Basic Information

Insect: Drosophila mimetica
Gene Symbol: MBD-R2
Assembly: GCA_037075245.1
Location: JBAMCH010000023.1:14247503-14251283[+]

Transcription Factor Domain

TF Family: MBD
Domain: MBD domain
PFAM: PF01429
TF Group: Unclassified Structure
Description: The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 1 3.1e-22 7.7e-19 67.2 0.1 3 76 448 519 446 520 0.93

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	1	3.1e-22	7.7e-19	67.2	0.1	3	76	448	519	446	520	0.93

Sequence Information

Coding Sequence: ATGGGTCGCCGCTGCTGCGTGGCCAACTGTCCGTCGACGTCGCGTCTGGTGGAGCACCACGGCGTGACATACCACTCCTTCCCCCTCGACCCCATCATCCGGGCCATTTGGATCAAGAACTCCCGCATCAGCCTGGATCGGCAGATCACCAAGAGCGTTTTGGTCTGCTCACGCCACTTCCGCCGCCTGGACTTCAACACGATCCGCAATGGCAAGTATCTGCTCAAGCCGCGCGTCTTTCCCACCGTCTTTCCGTGGGGCAAGATGGATTCGGCGGAGATCGAGGCGGATCACCGGGCACTGCAGCACGCCAGCGTAGAAGGAACGACTGGAGCACCGGGTTCCGCTCAATCCTCGGCCAACGAGGATGTGATCAAGGCCACGGTGGACCAAATAGTGGCGCAAATCCTGGCGGAAACAGCCGAACGCAAGGCCACCGAGGAGGCTAAGGCTGAaaaggcggaggaggaggccaaggCGACTTCTGAAGTCGGCGAAGATGCCACCAAGACTGCTACAGAGGAGGCCCCAGCTGCTCCTGGACCTTCAGCCCCGGAAACTACTGCCCCAGCTGCAGAAACCGCCTCCAATTCCAACTCCCCACTTCCCGGCACTCCGCCCAAGTACAGCAACCCACACAACCTGACTATCGGCGCCCGCTTGGAGGCCCTCAGTGTGGAGGGCAACTGGTTGCCCGCCCGCATCGTGGAGGTCAACGAGACGGAGCAAACGCTCCTGGTGCGTTTCGAGCGCAACCACAAGTTAAAGGTGTCGCCCTCGACGAGCGGCAGCTTCCAGGAGTGGATGGCCATCAAGTCGGAGCGGCTGAGGCAGCGCCTCAGCACCCGAGTGCTGCCCGTATTCGAACTGGAGGAGAAGTGCATGGCCCGCTGGTCGGGGCCGCGCAAGTTCCCGGGCACCATCCGCAAGCTGCTGGGCAATGACACCTACGAGGTGCTCTTCGACGATGGCTATATTAAGAACGTGCGCGCCGTGCATATGAACAAGATGCCGAAGCAACTACCAGCAGCTGTCCAGGCAACTGACGATTTGGCGTCCAAGGCGCCCACACCTGTTGGAACCCCAGTTAGCGCTGCACCTCTGGCTCCCAAAAGGGCCAGTACAGGCAGCGTAAGTGCAGCCAGCGGGTCGTCGAGCAGCAAGAAGAGCAAGAGCACTCCACAACGCAGGGACTGGCCCCTGTTAGACATGGCCAGTTTGGACATTGCTTCTCTAGGCCTCCCCGAGATTCCGCATGATGGAGAGTGGACTTGTCATTGGGTAAATGACCAGCCTATCGGAACCGAGGGCTTTCTAATTGTGGGCGAGCACCAGAAGCCCACGGTTATCGTGCAGGACTGGCGCCTGCCACCTGGCTGGATCAAGCACATGTACCAGCGCTCCAATGTGCTAGGCAAGTGGGATGTCATTCTCGTCTCACCCAGTGGCAAACGGTTCCGCTCCAAGTCCGATTTGAAGCTTTTCCTGGAGTCACAGGACCTAGTATACAACCCAGATGTGTATGACTTTAGCATTCACCGGCGACGGGCTAAGGACATCAACGCTTATGTCTACACCCACGACTACAATCCACAGCCACCGCCCAAGCCCAGGCCCATGGATGTGTCAATGGACTCCACTCTGAACCAGAGTAATACAACGCAACCATCGTTACCTTCGACCCCTATGCCGGTGAAAGAAAGCCAATATATGGAAGCGCCGGTGGCCTCACTCATGCCTCCGGCAGAGCTTATGTCGCCACAGGCTCAGCTTACCGATGAGACAAAGGTAAAGACAACCCCAGAATTACTGGAAGGCATTGAAGGAGCTCCTGCTCAACTATTGCCAGGAGATCCTCCGCTGGTGGAGAACGGCTTTGCTTTTATTGGTGGCTTAAAAGTCCAAATCCAGGACAATCTTTATGTATGTCCGCGTGAAGATTGCGGCAAGACGTATCGAAAAGAAGACTTTCTGCTCATCCACATTCGACATTACCACAAGGAGTTTGCCGAATACGTAAGCCACTGCCCAAAGATGCAGGAACTGGCGGTGAAGCGAACACATCCCTCATCCATTGAGCAGGGTGACGCAATGCCCAAGAACCAAATACCAAACCAGCAATTCTTTGCGAAGATGCACCAGCATGATCTGCAGCAGTCGCGATCATTTAAACGTCAGACGGTTACATCTCCTGGAACGCCGACAACGCCATCTGGAATATCGCCTTCTAAGGCTCTGTTATCTCCCAAGATGGAGCCGCCAGGCACAATGACGACCACTGTTGAAGGTGGTATTAATCCAGAAGATGTTTCTCTGGAGGCTGGAGATACCCTCTCGCTAAACCCAGCTTTAAATCGTTCCTGCAAGCGTGCTCGATACTCGCCGACAAAACGTCCATCTGGCTCCAGGAAGAGCAACCGACAGCGTTCTCAACGTCGGGGAAATTTGACGGACAGCCCGGCTGGTCATTCCTTGAACGAACAAGATCCCGAGGAGACGAGACAATCCTTTAACACCCCGACTCCCGATGCACGCAGCGACTCGAAGAAGCGACGCGTTGGTGCAGCTGCAACTCCCATTAGCTCCATTGACTCACCAGCCACGGCGGATTCGGTATCCACACCGTCATCTAATGACCAAGCGGATATTAATGCTGCTCTAGCTCCACCACCTGCTGAAAATAAAGCACCCCAGTACATCAAGGAGAACGGTGAGCTAATACGAATTGTGCGCATGCGGCAGGAGGAGATCATCAATTGCATCTGCGAGTACGGAGAAGAGGACGGTCTAATGATTCAGTGTGAATTGTGTTTGTGCTGGCAACATGGCGCCTGCAACGGGATTGTTAAAGAGTCGGATGTGCCGGACAAGTATGTGTGCTACATCTGTCGTAATCCGCAAAGAGGAAGGGACTCCATGCGTTTTAAGCATGACCAAGACTGGCTGTTCGAAGGCAAGTTGCCGGTGGCCGCGTACCACACTCCAAATCCACAGGCCACCAAGCAATTTGAGCTCTTGAAGCGCTCCCACACGTTGACCGGCAATTTACTCGATGCCAAGCGATCGATGCACTCGTTGCTTGTAAAGATCAATATAGCGCGTAACCGCTGTCACCCAAAGCTGTATTTGTGGGCCAAAAAGTGGGACGAGGATAACGTGGACGCCAATGCTGCGACGCCGGTAAAGCGCCCGAAGACGGAGCATCCTGACCTTCCAAACGTTCCGCAACCGGAGGCCGCCATCGACCCAGAGGAGTGCCAGTACCGTCTGATCGAGCATGTGAAGGTGCAGCAATCATTGGTCGTCAATCGACTCAATGACATCGAGGCAGAAATGGATGAACTTGAAAAAGAGGACAGTTTTGATGACTTAAAAGATGGGGATATCTCCACCACCAAAGAAGCGCTTGCTACATTCATCAAGGAGCTGGAAACCATGAAGCGCCTTGCCAGGCTTAACCAGGTGGCAAATCTGAAGCAGAGCCTTAAAGACTCTGCCATTcaccaataa
Protein Sequence: MGRRCCVANCPSTSRLVEHHGVTYHSFPLDPIIRAIWIKNSRISLDRQITKSVLVCSRHFRRLDFNTIRNGKYLLKPRVFPTVFPWGKMDSAEIEADHRALQHASVEGTTGAPGSAQSSANEDVIKATVDQIVAQILAETAERKATEEAKAEKAEEEAKATSEVGEDATKTATEEAPAAPGPSAPETTAPAAETASNSNSPLPGTPPKYSNPHNLTIGARLEALSVEGNWLPARIVEVNETEQTLLVRFERNHKLKVSPSTSGSFQEWMAIKSERLRQRLSTRVLPVFELEEKCMARWSGPRKFPGTIRKLLGNDTYEVLFDDGYIKNVRAVHMNKMPKQLPAAVQATDDLASKAPTPVGTPVSAAPLAPKRASTGSVSAASGSSSSKKSKSTPQRRDWPLLDMASLDIASLGLPEIPHDGEWTCHWVNDQPIGTEGFLIVGEHQKPTVIVQDWRLPPGWIKHMYQRSNVLGKWDVILVSPSGKRFRSKSDLKLFLESQDLVYNPDVYDFSIHRRRAKDINAYVYTHDYNPQPPPKPRPMDVSMDSTLNQSNTTQPSLPSTPMPVKESQYMEAPVASLMPPAELMSPQAQLTDETKVKTTPELLEGIEGAPAQLLPGDPPLVENGFAFIGGLKVQIQDNLYVCPREDCGKTYRKEDFLLIHIRHYHKEFAEYVSHCPKMQELAVKRTHPSSIEQGDAMPKNQIPNQQFFAKMHQHDLQQSRSFKRQTVTSPGTPTTPSGISPSKALLSPKMEPPGTMTTTVEGGINPEDVSLEAGDTLSLNPALNRSCKRARYSPTKRPSGSRKSNRQRSQRRGNLTDSPAGHSLNEQDPEETRQSFNTPTPDARSDSKKRRVGAAATPISSIDSPATADSVSTPSSNDQADINAALAPPPAENKAPQYIKENGELIRIVRMRQEEIINCICEYGEEDGLMIQCELCLCWQHGACNGIVKESDVPDKYVCYICRNPQRGRDSMRFKHDQDWLFEGKLPVAAYHTPNPQATKQFELLKRSHTLTGNLLDAKRSMHSLLVKINIARNRCHPKLYLWAKKWDEDNVDANAATPVKRPKTEHPDLPNVPQPEAAIDPEECQYRLIEHVKVQQSLVVNRLNDIEAEMDELEKEDSFDDLKDGDISTTKEALATFIKELETMKRLARLNQVANLKQSLKDSAIHQ

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00548102; iTF_00492225; iTF_00524450; iTF_00490116; iTF_00492268; iTF_00524407; iTF_00490075; iTF_00485129; iTF_00613544; iTF_00485176; iTF_00613501; iTF_00581570; iTF_00536806; iTF_00581526; iTF_00536761; iTF_00578579; iTF_00578533; iTF_00605564; iTF_00605609; iTF_00592386; iTF_00539653; iTF_00592424; iTF_00539692; iTF_00596653; iTF_00596692; iTF_00515587; iTF_00515629; iTF_00529558; iTF_00529598; iTF_00512041; iTF_00588138; iTF_00494380; iTF_00588179; iTF_00494421; iTF_00512000; iTF_00619146; iTF_00607787; iTF_00591693; iTF_00619182; iTF_00607825; iTF_00591732; iTF_00504722; iTF_00504683; iTF_00486559; iTF_00486600; iTF_00507647; iTF_00507608; iTF_00604836; iTF_00604837; iTF_00602630; iTF_00604879; iTF_00604880; iTF_00602587; iTF_00480205; iTF_00531694; iTF_00480159; iTF_00531647; iTF_00488657; iTF_00478050; iTF_00541066; iTF_00541110; iTF_00478011; iTF_00488700; iTF_00617641; iTF_00561797; iTF_00617686; iTF_00561751; iTF_00527340; iTF_00527300; iTF_00533134; iTF_00533094; iTF_00593870; iTF_00593828; iTF_00612849; iTF_00612806; iTF_00594585; iTF_00594543; iTF_00491548; iTF_00491506; iTF_00590229; iTF_00590274; iTF_00609205; iTF_00609163; iTF_00525913; iTF_00525872; iTF_00565369; iTF_00565411; iTF_00482973; iTF_00483018; iTF_00571934; iTF_00571890; iTF_00606302; iTF_00606352; iTF_00489408; iTF_00489367; iTF_00505440; iTF_00505399;
90% Identity: iTF_00548102; iTF_00581570; iTF_00536806; iTF_00581526; iTF_00536761; iTF_00604836; iTF_00604837; iTF_00604879; iTF_00604880; iTF_00602587; iTF_00602630; iTF_00486559; iTF_00486600; iTF_00578579; iTF_00578533; iTF_00605564; iTF_00605609; iTF_00529598; iTF_00529558; iTF_00512041; iTF_00588138; iTF_00494380; iTF_00588179; iTF_00494421; iTF_00512000;
80% Identity: iTF_00548102;