Basic Information

Insect: Drosophila sechellia
Gene Symbol: MBD-R2
Assembly: GCA_004382195.1
Location: NC:16165858-16169972[+]

Transcription Factor Domain

TF Family: MBD
Domain: MBD domain
PFAM: PF01429
TF Group: Unclassified Structure
Description: The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 1 6.3e-23 2.2e-19 68.5 0.1 3 76 444 515 442 516 0.93

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	1	6.3e-23	2.2e-19	68.5	0.1	3	76	444	515	442	516	0.93

Sequence Information

Coding Sequence: ATGGGCCGCCGCTGCTGCGTTGCCAACTGCCCGTCGACGTCGCGTCTGTTGGAGCACAACGGCGTGACCTACCACTCCTTCCCCCTGGATCCCATCATCCGGGCCATTTGGATCAAGAACTCTCGCATCAGCCTGGAGCGCCAGATCACCAAGAGCGTGCTGGTCTGCTCACGCCACTTCCGCCGTTTGGACTTCAATACGATCCGCAATGGGAAGTATCTGCTCAAGCCGCGCGTCTTTCCCACCGTTTTTCCGTGGGGCAAGATGGAGACCGCGGATATCGAAGCTGACCAACGGGCACTTCAGCATGTCAGCGTGGAGGGAACGTCTGAAACCCCGGGAAATGCTCAGTCATCGACCAATGACGATACGGCGGTACAGCGAATAGTCGCGAAAATCATGTCGGAAACTGCAGAACGCAAGGCCAAGGAGGAAGGTAAAACAGACAAGGCGCAGGATGATGTCAAAACTACGCCCGAAAGCGGCGAAGATGCAAACCAGGCAGCTGCAAAGGAACCCCCAGGGACTCCGGTAGCCCCAAGCAGCGATGCCACAGTCCCAGCTCCTGGATCCGCCTCCAGTTCGAACTCCCCTTTGCCCGGCACACCGCCCAAGTACAGTAACCCACATAACCTGACTATCGGCGCCCGTTTGGAGGCGCTCAGTGTGGAGGGCAACTGGTTGCCCGCCCGAATCGTGGAAGTAAACGAGACGGAGCAGACGCTACTTGTGCGCTTTGAGCGCAATCACAAGCTAAAGGTGTCACCGTCGACCAGCGGCAGCTTTCAGGAGTGGATGACCATCAAGTCGGAGCGGCTGAGGCAGCGCCTCAGCAACCGTGTGCTGCCCGTCTTTGAGCTGGACGAGAAGTGCATGGCCCGCTGGTCGGGCCCGCGTAAGTTTCCAGGAACCATACGCAAGTTGCTGGGAAACGATACTTACGAGGTTCTCTTCGACGATGGTTACGTTAAGAACGTGCGCGCCGTGCACATGAACAAGATGCCCAAGCAGTTGCCCCCTGTTCAGGCAGCGGAAGAAGGTGCCTCAAAGTCACCTACTCCTGTTGGAACTTCAGTTAGCTCTGCACCTGTGGCTCCGAAGAGGGCGAGCACAGGCAGCCTTGGCGGAGCCAGTGGCTCTTCCGGCAGCAAGAAGAGCAAATCTGCTCCTCAGCGCAGGGATTGGCCGTTGCTGGACATGGCCAGTTTGGATATAGCATCCCTTGGACTCCCAGAAATACCGCATGACGGCGAGTGGACTTGTCATTGGGTAAATGACCAGCCTATTGGAACCGAGGGTTTCCTGATTGTGGGCGAGCACCAGAAACCCACTGTTATCGTGCAGGATTGGCGTCTGCCTCCTGGCTGGATCAAGCACATGTACCAGCGCTCCAACGTCCTCGGCAAGTGGGATGTTATTCTGGTCTCTCCCAGCGGCAAACGTTTCCGCTCCAAGTCCGACTTGAAGTTGTTCCTTGAGTCCCAGAATTTGGTCTACAACCCGGACGTGTACGACTTTAGCATCCATCGACGTCGTGCCAAAGACATCAATGCTTACGTCTACACACACGGCTACAATCCGCAGCCACCGCCCAAGCCCAAGTCCATGGATGTGTCGATGAACTCCTCACTGGACCAGAGCATCACCTCGCAGCATTCTTTACCTTCTACTCCGATGCCGGTGAAAGAAAGCCAGTACATGGAAGCACCGGTGGCCTCGCTTATGCCACCAGCCGAGTTAATGTCGCCGCAGACGCAGCCTGTCGATGAGACAAAGCCCGAGACAGGAGCAGAAATACTGGAAGCCAGTGAGGAAGGTAACTCTCAGCTTTTGTTAGGGGATTCTCATGTGGTGGAAAATGACTTTGCTTTCATTGGGGGCCTAAAAGTCAAAATGCAAGACAATCTTTATGTATGCCCGCGCGAAGATTGCGCCAAGACCTATCGCAAAGAAGACTTTCTGCTAATCCACATACGCCATTATCACAAGGAGTTTGCAGAacaCGTCAGCCACTGTCCAAAGATGCAGGAACTAGCGGTCAAACGTACACATCCCTCATCCATCGATCAAGTTGAGGGGGTGCCAAAAAATCAAATACCCAACCAGCAATTCTTTGCCAAATTGCACCAGCAGGATTTGCAGCAGTCACGATCGTTTAAACGACAGAGTGTATCAGCTACGACGCCATCTTCTGCAGGACCGGCAACTCCATCTGACATACCGCCTAAGACCCTGTTATCTCCTAAGATGGAGCCACCAAGTGTGTCGCCAACTGTTGAAAGCGTCATTAAACAAGAAGATATTTCGCTGGACGCTGGTGCAACTCAGTCGTTTAACCCTTCATTGAGCCGCTCCTGCAAGCGTGCACGGTTGTCGCCATCGAAGCGGCCATCTGGCTCGCGGAAGAGTAACCGCCAGCGCTCTCAGCGCCGCCCCTATTTGTCAGACAACCCAGCTGGTCCTGGCTTAACCGAACAAGACGTTGAGGAGACACGGCAATCATTTAACACCCCTACTCCGGATACGCGCGTCGACTCGAAGAAACGCCGCGGTGGTGCGCCAACAACTCCCATCAGTTCCGTTGACTCACCAGCTATGGTAGATTCGGTGTCCACGCCATCATCTAATGACCAGGCCGACATTAATGCAGCCCTTGCCCCACCACCAACTGAAGCGCTAAACAAAGCACCGCAGTACATCAAGGAAAATGGAGAACTAATTCGAATTGTGCGCATGCGGCAGGAGGAGATCATTAATTGCATCTGCGAGTATGGCGAAGAGGACGGCCTAATGATCCAATGTGAATTGTGTCTATGCTGGCAACACGGTGCATGCAACGGAATTGTCAAAGAGTCAGATGTACCGGACAAGTATGTGTGCTACATTTGTCGTAATCCGCAGAGAGGTCGGGATTCGATGAAATTTAAGCACGACCAAGACTGGCTATTCGAAGGCAAGTTGCCGATGGCCGCGTATCACACTGCAAATCCACAGGCCACCAAACAATTCGAGCTCTTGAAGCGCTCGCACACGCTGACCGGCAATTTGCTAGATGCCAAGCGATCGATGCACTCGCTGCTGGTGAAGATTAACATCGCACGCAACCGCTGTCATCCGAAGCTTTATCTGTGGGCCAAAAAGTGGGACGAAGACAATCTGGACTCTACTGCGTTGACACCGGTTAAGCGACCAAAATTGGAGTCCCCTGACCTTCCGAACGTTCCGCAACCGGAAGCTGCCATCGATCCGGAGGAGTGCCAGTACCGTTTGATCGAGCATGTGAAGGTGCAGCAGTCCTTGGTCCTCGATCGGCTGAATGACATAGAAGCCGAAATGGACGaACTTGAAAAAGAGGACACGTTGAATGACTTAAAGGACGCTGACATCTCGACCACGAAAGAGGCGCTGGCCACGTTTGTCAAGGAGCTCGAAACCATGAAGCGCCTTGCCAAGCTCAACCAGGTGGCCAATATGAAGCAGACCCTCAGAGATTCTGCCACCAGCAAGTAG
Protein Sequence: MGRRCCVANCPSTSRLLEHNGVTYHSFPLDPIIRAIWIKNSRISLERQITKSVLVCSRHFRRLDFNTIRNGKYLLKPRVFPTVFPWGKMETADIEADQRALQHVSVEGTSETPGNAQSSTNDDTAVQRIVAKIMSETAERKAKEEGKTDKAQDDVKTTPESGEDANQAAAKEPPGTPVAPSSDATVPAPGSASSSNSPLPGTPPKYSNPHNLTIGARLEALSVEGNWLPARIVEVNETEQTLLVRFERNHKLKVSPSTSGSFQEWMTIKSERLRQRLSNRVLPVFELDEKCMARWSGPRKFPGTIRKLLGNDTYEVLFDDGYVKNVRAVHMNKMPKQLPPVQAAEEGASKSPTPVGTSVSSAPVAPKRASTGSLGGASGSSGSKKSKSAPQRRDWPLLDMASLDIASLGLPEIPHDGEWTCHWVNDQPIGTEGFLIVGEHQKPTVIVQDWRLPPGWIKHMYQRSNVLGKWDVILVSPSGKRFRSKSDLKLFLESQNLVYNPDVYDFSIHRRRAKDINAYVYTHGYNPQPPPKPKSMDVSMNSSLDQSITSQHSLPSTPMPVKESQYMEAPVASLMPPAELMSPQTQPVDETKPETGAEILEASEEGNSQLLLGDSHVVENDFAFIGGLKVKMQDNLYVCPREDCAKTYRKEDFLLIHIRHYHKEFAEHVSHCPKMQELAVKRTHPSSIDQVEGVPKNQIPNQQFFAKLHQQDLQQSRSFKRQSVSATTPSSAGPATPSDIPPKTLLSPKMEPPSVSPTVESVIKQEDISLDAGATQSFNPSLSRSCKRARLSPSKRPSGSRKSNRQRSQRRPYLSDNPAGPGLTEQDVEETRQSFNTPTPDTRVDSKKRRGGAPTTPISSVDSPAMVDSVSTPSSNDQADINAALAPPPTEALNKAPQYIKENGELIRIVRMRQEEIINCICEYGEEDGLMIQCELCLCWQHGACNGIVKESDVPDKYVCYICRNPQRGRDSMKFKHDQDWLFEGKLPMAAYHTANPQATKQFELLKRSHTLTGNLLDAKRSMHSLLVKINIARNRCHPKLYLWAKKWDEDNLDSTALTPVKRPKLESPDLPNVPQPEAAIDPEECQYRLIEHVKVQQSLVLDRLNDIEAEMDELEKEDTLNDLKDADISTTKEALATFVKELETMKRLAKLNQVANMKQTLRDSATSK

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00548059;
90% Identity: iTF_00539653; iTF_00592424; iTF_00539692; iTF_00596653; iTF_00596692;
80% Identity: iTF_00592424;