Basic Information

Insect: Drosophila rufa
Gene Symbol: MBD-R2
Assembly: GCA_018153105.1
Location: JAECXS010000001.1:13017852-13021656[-]

Transcription Factor Domain

TF Family: MBD
Domain: MBD domain
PFAM: PF01429
TF Group: Unclassified Structure
Description: The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 1 3.5e-22 1.1e-18 66.4 0.1 3 76 462 533 460 534 0.93

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	1	3.5e-22	1.1e-18	66.4	0.1	3	76	462	533	460	534	0.93

Sequence Information

Coding Sequence: ATGGGTCGCCGCTGCTGCGTGGTCAACTGCCCGTCGACATCGCGCCTGCTGGAGCACCACGGCGTCACCTACCACTCGTTCCCCCTTGACCCCGTCATCCGGGCCATCTGGATCAAGAACTCGCGCATCAGCCTGGACCGCCAGATCACCAAGAGCGTGCTCGTCTGCTCGCGCCACTTCCGCCGCCTGGACTTCAACACGATCCGCAATGGCAAGTACCTGCTGAAGCCGCGCGTCTTCCCCACCGTCTTCCCGTGGGGCAAGATGGACTCCGCCGAGATCGAGGCGGACCACCGGGCCCTGCAGCAGGCCAGCGTCGAGGGCACGGCGGTCGCTGGAACCGAACACACGTCGGCCAACGAGGATGTGATCAAGGCCACGGTCGACAATATTGTGGCGCAAATTCTGGCGGAGACCGCCGAACGTAATTCCTCGGCAGCTGCTGAGGAGCCCAAGGCGGACAAGGAGAAGGACCCGGCAAAGACCACTACTCCCCCCAAGGCTAGCGAGGAGGCGCCCAAGCCAGCTGAGGATTCGGCAGCTGCTTCCACTGTTGCTCAGGCCAGCGAAGTGGCTGCCCTCACAGCGGCTGCCACTTCCGCCTCCAACTCGCCGCTGCCTGGGACGCCGGTGAAGTACAGCAACCCCACCAACTTGACCATCGGCGCACGCTTGGAGGCCCTGAGTGTGGAGGGCAACTGGCTGCCCGCCCGCATCGTCGAGGTGAACGAAACCGAGCAGACGGTGCTCGTGCGCTTCGAGCGCAACCACAAGCTAAAGGTGTCGCCCTCGACGAGCGGCAGTTTCCAGGAGTGGATGGCCATTAAGTCGGAGCGGCTGAGGCAGCGCCTCAGCAACCGCGTGCTGCCCGTCTTCGAGCTGGAGGAGAAGTGCATGGCCCGCTGGTCGGGGCCGCGCAAGTTCCCGGGCACCATTCGCAAGCTGCTGGGCAACGACACCTACGAGGTGCTCTTCGACGATGGATACACCAAGAATGTGCGCGCCGTGCACATGAACAAGCTGCCCAAGCAGCTGCTTCCCATCGAGGGATCGGGATCGGATGGCGTGCCAGCTAAGGCTGCAGCTCCAGCTGCGCCTGGAACGCCAGCTCCACCTGGAACTCCAGTTCCAGCCGCTGTGCCTGCGGCTCCAAAGAGGGTCAGTACTGGCAGCGTGAGCAGCACCAGTGCTGGCTCCAGCAGCAAGAAGAGCAAGAGCACGCCCCAGCGCAGGGACTGGCCGCTGCTGGACATGGCCAGCTTGGATATAGCTGCTCTGGGCTTGCCCGAGATTCCGCATGACGGGGAGTGGACCTGCCACTGGGTGAACGACCAGCCGATCGGAGCCGAGGGCTTCCTCATCGTGGGCGAGCACCAGAAGCCCACAGTGATCGTGCAGGACTGGCGTCTGCCGCCCGGCTGGATCAAGCACATGTACCAGCGCTCCAACGTGCTCGGCAAGTGGGACGTCATCCTGGTCTCGCCCAGCGGCAAGCGCTTCCGCTCCAAGTCCGACCTGAAGGTGTTCCTCGAGTCGCAGGACCTGGTCTACAACCCGGACGTGTACGACTTCAGCATCCACCGGCGCCGGGCCAAGGACATAAATGCCTATGTCTACACACACGACTACAATCCGCAGCCACCGCCCAAGCCCAAGCCCATGGATGTCTCCCTGGACGCCACGTTGGACCGCAGCAACGCAACTCTCCCCCCATCCTTGCCATCGACTCCGATGCCCGTCAAGGAGAGCCAGTACATGGAGGCGCCGGTGGCCTCGCTGATGCCGCCAGCGGAGCTCATGTCGCCGCAGGCTCAGCTCACTGATGAAGCCAAGCCGAAGACAAGCCCAGAGCTGTTGGAAGCCGTTGAAGCTGGTGCCGCCGCCCCGCCTTTGGAAGGAGGCGCAGCTCTGGTGGAGGATGGCTTTGCTTTTATTGGCGGTCTAAAAGTCCAGCTCCAGGAGAACCTGTATGTTTGCCCGCGCGAAGGCTGCGGTAAGACCTATCGCAAGGAGGACTTCCTGCTCATTCACATCCGTCATTACCACAAGGAGTTCGCAGAATACGTGAGCCACTGTCCAAAGATGCAGGAGTTGGCCGTCAAGCGGACACATGCCTCCTCCATCGAGCAGGGCGAGCCAACACCCAAGAATCAAATACCGAACCAGCAATTCTTTGCCAAGCTGCACCAACAGGATATGCAGCAGTCGCGGGCCTTCAAACGTCAGTCGCTTCCCCCAACAGTCACATCACCCAAGGCGACTGGAACTCTGCCAGATAAGGCGCTTGTATCGCCCAAGACGGAGCCATTGGGCACGTCCACGCCCACTGCTGAGAGTGGAATCCATCCGGAGGAGGTTCCGTTGGAGGTCGGAGCTACCATCGCGCTGAACCCCGCACTCAGCCGCTCCAGCAAGCGGGCTCGGGCCTCGCCGACAAAGCGTTCATCCGGCTCGAGGAAGAGCAACCGCCAGCGCTCGCAGCGTCGCAGCAATGTGACTGACACTCCGACTATGCCCAACCTGAGCGAACATGATGCCGACGAGACGCGTCAGTCCTTCAACACGCCCACGCCGGATAGCCGCATCGACGCAAAGAAACGTCGCGTTGGTCCGGCAGCCACACCCGTCAGCTCGATTGACTCTCCGGCTATGGCAGATTCTGTGTCCACACCGTCGTCCAACGACCAGGCGGACATTAATGCCGCCCTGCCGCCGCCCGTAGACACAATGGGAAAGGCGCCGCAGTACATCAAGGAGAACGGGGAACTAATACGCATCGTGCGCATGCGGCAGGAGGAGATCATCAATTGCATCTGCGAGTACGGCGAGGAGGACGGCCTGATGATCCAGTGCGAGCTGTGCCTGTGCTGGCAGCATGGCGCCTGCAATGGCATCATAAAGGAGTCGGACGTGCCGGACAAGTACGTCTGCTATATCTGCCGCAATCCGCAAAGGGGACGCGACTCGATGAGGTTCAAGCATGACCAGGACTGGCTCTTTGAGGGAAAATTGCCGGTGGCCGCGTACCACACGGCCAATCCGCAGGCCACCAAGCAGTCCGAGCTACTGAAGCGCTCGCATACGCTCACTGGCAACCTGCTGGACGCCCGGCGCTCGATGCACTCGCTGCTGGTAAAGATCAACATCGCTCGCAACCGCTGCCACCCCAAGCTGTATCTGTGGGCCAAGAAGTGGGATGAGGACCAGGTGGACGCCGCTGCCTTGACGCCGGTGAAGCGACCGAAGACTGAAATTCCTGACCTTCCACACGTCCCGCAGCCGGAGGCCGCCATCGATCCCGAGGAGTGCCAGTACCGGCTGATCGAGCACGTGAAGGTGCAGCAGTCCCTGGTCCTCAACCGACTCAACGACATTGAGGCCGAAATGGATGAGCTTGAAAAGGAGGACAGCCTGGAAGACCTGAAGGATGGCGATATCTCCACCACCAAAGAGGCCATGGCCGCGTTCATCAAGGAGTTGGAGACCATGAAGCGTCTGGGCCGTCTCAACCAGGTGGCCAATATTAAGCAGAGCTTGAAAGACTCTGCCCCAAACCATTAA
Protein Sequence: MGRRCCVVNCPSTSRLLEHHGVTYHSFPLDPVIRAIWIKNSRISLDRQITKSVLVCSRHFRRLDFNTIRNGKYLLKPRVFPTVFPWGKMDSAEIEADHRALQQASVEGTAVAGTEHTSANEDVIKATVDNIVAQILAETAERNSSAAAEEPKADKEKDPAKTTTPPKASEEAPKPAEDSAAASTVAQASEVAALTAAATSASNSPLPGTPVKYSNPTNLTIGARLEALSVEGNWLPARIVEVNETEQTVLVRFERNHKLKVSPSTSGSFQEWMAIKSERLRQRLSNRVLPVFELEEKCMARWSGPRKFPGTIRKLLGNDTYEVLFDDGYTKNVRAVHMNKLPKQLLPIEGSGSDGVPAKAAAPAAPGTPAPPGTPVPAAVPAAPKRVSTGSVSSTSAGSSSKKSKSTPQRRDWPLLDMASLDIAALGLPEIPHDGEWTCHWVNDQPIGAEGFLIVGEHQKPTVIVQDWRLPPGWIKHMYQRSNVLGKWDVILVSPSGKRFRSKSDLKVFLESQDLVYNPDVYDFSIHRRRAKDINAYVYTHDYNPQPPPKPKPMDVSLDATLDRSNATLPPSLPSTPMPVKESQYMEAPVASLMPPAELMSPQAQLTDEAKPKTSPELLEAVEAGAAAPPLEGGAALVEDGFAFIGGLKVQLQENLYVCPREGCGKTYRKEDFLLIHIRHYHKEFAEYVSHCPKMQELAVKRTHASSIEQGEPTPKNQIPNQQFFAKLHQQDMQQSRAFKRQSLPPTVTSPKATGTLPDKALVSPKTEPLGTSTPTAESGIHPEEVPLEVGATIALNPALSRSSKRARASPTKRSSGSRKSNRQRSQRRSNVTDTPTMPNLSEHDADETRQSFNTPTPDSRIDAKKRRVGPAATPVSSIDSPAMADSVSTPSSNDQADINAALPPPVDTMGKAPQYIKENGELIRIVRMRQEEIINCICEYGEEDGLMIQCELCLCWQHGACNGIIKESDVPDKYVCYICRNPQRGRDSMRFKHDQDWLFEGKLPVAAYHTANPQATKQSELLKRSHTLTGNLLDARRSMHSLLVKINIARNRCHPKLYLWAKKWDEDQVDAAALTPVKRPKTEIPDLPHVPQPEAAIDPEECQYRLIEHVKVQQSLVLNRLNDIEAEMDELEKEDSLEDLKDGDISTTKEAMAAFIKELETMKRLGRLNQVANIKQSLKDSAPNH

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00548059;
90% Identity: iTF_00590274; iTF_00480205; iTF_00531694; iTF_00480159; iTF_00531647; iTF_00609205; iTF_00609163; iTF_00482973; iTF_00483018; iTF_00571934; iTF_00571890; iTF_00606302; iTF_00606352;
80% Identity: iTF_00590274;