Dmer001735.1
Basic Information
- Insect
- Drosophila meridionalis
- Gene Symbol
- Lztr1
- Assembly
- GCA_035045145.1
- Location
- JAWNPG010000009.1:12192379-12195943[+]
Transcription Factor Domain
- TF Family
- BTB
- Domain
- zf-C2H2|ZBTB
- PFAM
- PF00651
- TF Group
- Zinc-Coordinating Group
- Description
- The BTB (for BR-C, ttk and bab) [6] or POZ (for Pox virus and Zinc finger) [1] domain is present near the N-terminus of a fraction of zinc finger (Pfam:PF00096) proteins and in proteins that contain the Pfam:PF01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerisation and in some instances heteromeric dimerisation [1]. The structure of the dimerised PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule [2]. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT [5, 3, 4]. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 4 8.2e-14 2.1e-11 44.0 0.8 1 107 555 695 555 698 0.87 2 4 0.31 78 3.6 0.1 77 109 697 729 693 730 0.90 3 4 1.8e-19 4.5e-17 62.3 0.0 8 97 789 878 783 893 0.85 4 4 6.5 1.7e+03 -0.7 0.0 72 100 887 915 881 923 0.84
Sequence Information
- Coding Sequence
- ATGCTTAAGTCCATACTTGGCGCAGACTCGAATGGTTCTGCGGAAGATCTACCAAGCGGAGGCGTTGGCGTTGTCGTCGCCAGCGGCAGTAGCGGGGgaagtggcagtggcagcagccgcGGTGCTGGAGCGCTAAGCCGAGCCAGTTACGGCCACGGCTCCAGCTCAATATCGAGTGGTCTAAGTGCGGTTTGTGGCTTGGTCGGaagcggcagtggcagtggcagcggcagtggcagtgcAAGTGCGAGTGCAAGTGGTGGCAGCACACCAGCTACCGTGTATTGCCCTGCATGCGTGGCGAACAGctcacagcaacagcagcagcaggcacttGCCTCTGGGGCTGAGGGTTTGCCAACGCGAGAGTCGAAATCGGGAAAGCGGGTGAAGACGCGGAAGAGTGCATCAACGGCTGGCTGCTTGGACGCTCAACATATACGCAACCATCTGAAAATGTCAACATCGAGCTCCATGCGCAGCACTCGCGGCAAtggcgctggcagcagcagcagcagcagcaccgccTCGGCTGTCATACCATCCGGTTGCAGCAGCATCGCCTACGATtccaacagcaacggcagctgcagcagcttcaaTGGCAAAGTCAACTCTCCTGGCAGCTACAGCTGCAATGCGCTCAATGTCGACTTCAGCACTTATACGGCAACGCATCAGTGGTCGCGCATGCTCGAGTGTGCAGAGTTTGTGGGCGCCAAGCGAAGCAAGCACACTGTGGTTGCCTATAAGGATGCCATGTTCGTGTTTGGCGGCGACAACGGCAAGACTATGCTCAACGATCTAATTAGGTTCGGAGTCAAGGACAAGTCCTGGGGACGTGCATGCGCAACGGGCACACCACCAGCTCCGCGCTACCATCATTCGGCAGTTGTGGCTGGCAGTTCGATGTTCATCTTTGGCGGCTATACGGGCGACATCCACTCCAACTCGAATCTGACCAACAAGAATGATTTGTTTGAGTATAAGTTTCTCAGCGCCATGTGGGTGGAATGGAAGTTttcaggcaggcagccagtgCCCAGGTCGGCGCATGGTGCCGCTGTTTATGATAACAAAATGTGGATATATGCTGGCTACGATGGCAATGCACGATTGAATGATATGTGGACTTTAAATTTGACGGGCGAGAATCACCAGTGGGAGGAGGTGGAACAGCAAGGTGATCGTCCGCCCACTTGCTGCAATTTTCCCGTCGCTGTTGCACGCGATGCTATGTACGTTTTCTCTGGCCAGAGCGGCCTGCAGATCACCAATTCTCTGTTCGAGTTTCACTTTAAGACGCGCACTTGGCGTCGCATATCCAATGAACCGGTTCTACGTGGTGCCACCTCAGCGCCACCATCGCGTCGCTATGGCCACACCATGGTGCATCATGATCGTTTCCTCTATGTTTTTGGCGGCTCAGCGGACTCCATGTTGCCAAATGATTTGCACTGTTACGATCTGGACTCGCAGGTGTGGTCCGTCATACAGCCGGAGCAGAACTCGGATGTGCCATCGGGTCGCGTTTTCCATGCATCGGCCGTCATTAGTGATGCCATGTATATCTTTGGTGGAACCGTTGACAACAGCGTGCGACGCGGCGATACCTATCGCTTTCAGTTCTCCAGCTATCCGAAGTGCACGCTGCGCGATGACTTTGGCAAATTCTTTCACGAGAAACAGTTCTGTGATATTCAGTTTGTGGTGGGTGCCGAGGAGATACGCATCCTGGCCCACATTGCCTTTGTGGCAGCACGCTCCAAGTATTTGCGGAACAAGATATTGTCGGCGCGTGAGGCGCTTCAGCATCAGATGGAAAAGCTTTATGGCGTCGGCCAGGTGGATGCACTTGCTCTGAATACCGGTGTTGGTGCCGATCGCACGCCCATGCTGGAGGTGCGACTGTCACATGCCTCGCCCGAGGCATTCGAAATCATACTCAACTACATCTATACGGATCGTATTGACCTGAAGGAGTCCTACAACAAGAACATCATCATTCTCATCACCGACATCTATCAATTGGCTGGCCTCTTCACGATGCCCCGCCTGGCGCAGGGCTGCATTCAGTATCTGGACTTTAAGATCAACAAGATAAACGTGCTCGAAGCGCTCTACAATGCGGACAAGAACAATATTAAAATCATCAAGGATCATTGCATGCAGTTCATCATCAAAGACGAGAACTTCACCGAGGTTGTCATGTCCAGTGAGTTTAGCGACCTGGACAAGCCGCTCCTAGTCGAGATCATACGCAAGCGCTTGCATCCCAGCAAGCTGGTCATGGACACCAGCTTTGAGTCGAATATCGgTACCACATTGGAGCACGATTTGTCGATGTTCTTAGAGACAACGGGTAAAGACTTCTGCGATATAAGTCTCAGACTGGAAGATCAGGTGATAGCGGCCCATAAGTCTGTACTATCAGCCCGTTGTACCTATTTCCAGGGCATGTTCCGCTCGTTTATGCCACCGGATAATACCGTCAATATACAAATTGGCGAAATTTCACCCTCACTGGAGGCATTTCACTCGCTGCTGCGCTATATATATTACGGGGAGACAAAAATGCCGCCGCAGGATGCGCTCTATCTGTTCCAGGCACCGTGCTTCTATGGCCTATCGAATAATCGTTTGCATGCATTCTGCAAATACTCACTGGAGCATAATATAACGTCAGAGAATGTGCTGCAGACGCTGGAGGCGTCCGATATAACTAAAATCTATGACATCAAGGATTATgcattgaaattaattgtGAAAGATTTTGCCAAGGTGGCCAGGCTACCAAAGATAGCCGGTTTGTCGCGCGAACTGTTGCTGGAGATAATACGCGCTGTGGCCGATTCGCAAGGCGAGTTTCTGACCCGCATCAATATCAATACCGATATCTGA
- Protein Sequence
- MLKSILGADSNGSAEDLPSGGVGVVVASGSSGGSGSGSSRGAGALSRASYGHGSSSISSGLSAVCGLVGSGSGSGSGSGSASASASGGSTPATVYCPACVANSSQQQQQQALASGAEGLPTRESKSGKRVKTRKSASTAGCLDAQHIRNHLKMSTSSSMRSTRGNGAGSSSSSSTASAVIPSGCSSIAYDSNSNGSCSSFNGKVNSPGSYSCNALNVDFSTYTATHQWSRMLECAEFVGAKRSKHTVVAYKDAMFVFGGDNGKTMLNDLIRFGVKDKSWGRACATGTPPAPRYHHSAVVAGSSMFIFGGYTGDIHSNSNLTNKNDLFEYKFLSAMWVEWKFSGRQPVPRSAHGAAVYDNKMWIYAGYDGNARLNDMWTLNLTGENHQWEEVEQQGDRPPTCCNFPVAVARDAMYVFSGQSGLQITNSLFEFHFKTRTWRRISNEPVLRGATSAPPSRRYGHTMVHHDRFLYVFGGSADSMLPNDLHCYDLDSQVWSVIQPEQNSDVPSGRVFHASAVISDAMYIFGGTVDNSVRRGDTYRFQFSSYPKCTLRDDFGKFFHEKQFCDIQFVVGAEEIRILAHIAFVAARSKYLRNKILSAREALQHQMEKLYGVGQVDALALNTGVGADRTPMLEVRLSHASPEAFEIILNYIYTDRIDLKESYNKNIIILITDIYQLAGLFTMPRLAQGCIQYLDFKINKINVLEALYNADKNNIKIIKDHCMQFIIKDENFTEVVMSSEFSDLDKPLLVEIIRKRLHPSKLVMDTSFESNIGTTLEHDLSMFLETTGKDFCDISLRLEDQVIAAHKSVLSARCTYFQGMFRSFMPPDNTVNIQIGEISPSLEAFHSLLRYIYYGETKMPPQDALYLFQAPCFYGLSNNRLHAFCKYSLEHNITSENVLQTLEASDITKIYDIKDYALKLIVKDFAKVARLPKIAGLSRELLLEIIRAVADSQGEFLTRININTDI
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- iTF_00479535;
- 90% Identity
- iTF_00561095;
- 80% Identity
- iTF_00544550;