Dmel000598.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Drosophila melanocephala
Gene Symbol
Ibtk
Assembly
GCA_037043625.1
Location
JBAMBD010000010.1:214918-219421[+]

Transcription Factor Domain

TF Family
BTB
Domain
zf-C2H2|ZBTB
PFAM
PF00651
TF Group
Zinc-Coordinating Group
Description
The BTB (for BR-C, ttk and bab) [6] or POZ (for Pox virus and Zinc finger) [1] domain is present near the N-terminus of a fraction of zinc finger (Pfam:PF00096) proteins and in proteins that contain the Pfam:PF01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerisation and in some instances heteromeric dimerisation [1]. The structure of the dimerised PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule [2]. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT [5, 3, 4]. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 3 3.3e-05 0.0081 16.2 0.2 4 79 567 638 564 686 0.86
2 3 2.9e-17 7e-15 55.1 0.7 8 107 703 807 696 810 0.87
3 3 0.64 1.6e+02 2.4 0.2 65 109 799 841 795 842 0.79

Sequence Information

Coding Sequence
ATGCTCGAAAATACCTCTTCATTGTACTTGCCTGCAGTGGTCAGTAACGACTCTAAAAACCAGGATTATGACTGTACCGTCAAGTGCCGTCGTCGCGAGCACGGCAATTGCATTACTGCGGCGCTCACAAAACGTTCCATTGACGATCAACATTTGGCGGCTTTCGTTGCAAAATCGTGTGCCAATTTTAGCAATATTCATGATTATCTGGGTCGCTCCGCCGTCCACATGAGCGCATCTGTCGCCCGTTACAAAATACTCGAATGGCTCTTGAACCACGGCGCCCTCGTCAACGAACGCGACTACGAATCGGGCAGCAGTCCGTTGCACCGGGCTCTGTATTACGGCTGCATCGATTGCGCCGTGCTATTGTTGCGCTATGGCGCCAGCCTGGAGCTGCTGGATGAGGACACCCGCTGTCCGCTGCAGGCCATTTGCAGGAAGTGTGACCTGGATCCCAGTGCTGACTCGCAAAATGAGACACTCGTTTGGGGCTCGAATAAGAATTATAATCTGGGCATTGGCAATGAACAGAATACGAATGCACCGCAGGCGGTGGATTTCTTTCGCAAATCTAATATTTGGATCGAGCACGTTGCACTGGGCGCCTATCACAGTCTCTTCTGCGACAAGAAGGGCCACCTGTATGCCGTGGGACATGGCAAGGGCGGTCGGCTCGGTATCGGTGTGGAGAACAGTTTGCCGGCACCGAAGCGCGTGAAGGTGCCACTGAAGCAATCGGATGAGCGCATCATCTGCATCAGTGTGTCCCGGCAGCATTCGTTGGTGCTCACCAATCGCTCGCTCGTCTTTGCCTGCGGCGTCAACGACAATCAGCAGCTGGGCGTACGTGATGCGGGCGAGCAGTTGACCACTTTCAAGGAAGTGGTCTCGTTGCGCGACAAGAGCGCCACTGGCCTGCTGCGTGTGATTGCCTGCGATCAGCACTCCATTGCCTACAGCTCCAAGTGCATTTATGTGTGGGGCGCCAATCAGGGACAGTTTGGCATCAGCGCCAAAACCAAGACAATTGTGTCACCCACACAGATGAAGCTGGCGGAGCGCACACACATCCGCTTTGTGGAGGCTAACAATGCAGCCACCGTGGTCTATACCGAAGAGAAGCTCATACTGCTCTTCTACGCGGACAAGCCCCGAACTATAAAGACGCCCAACTATGAGGATCTCAAGAGCATCGCGGTGATAGGCGGCAATCTGAAGAACTCCGCAAAAGGCTCGGCAGTTGCTCTCAAACTAATGATGCTAACCGAAACAAATGTCGTATTTCTCTGGTACGAGAATACACAGCAGTTCTACAGATGCAACTTTGCGCCCATACGCATGCCGGAGATCAAGCGCATCCTGTACAAATGCAACCAGGTGCTGGTGCTCTCCATGGATGGCTGCGTCTATCGCGGCAAATGCAATCAGCTGGCGTTGCCTGCTGAAAGTGCGCAGGATAAGCCCAAGGCCAACGTGGACATCTGGCAGAACAACGATCAGAATCGCACAGAAATCTCGCGGGAGCATTACGTACGCATCGATCTGCAGCGTGTGCCCAATATTGATCGAGCCGTGGACATCGTTTGCGACGAGAGCTTCACTTCGTTTGCCGTGCTCCAGGAGTCGCACATGAAGTACTTCCGTAAGCCAACGCTGCCGCGCAGGGAGCACAGTTTTAAGAAACTCTACCACGACACCAGCGAATCGGACGCCGTGCACGATATAATCTTCCATGTGGATGGCGAGCTCTTTGCGGCGCACAAGTTTATCATCTTCAATCGGGCAGCCGGACTGCGCGAACTAGTGCGCCTTTATCTAGACAAAGATATCTATCTGAATTTTGAGAATTTGACGGGAAAAATGTTTGAGCTGGTCCTCAAGCACATCTACACCAACTACTGGCCCACAGAGGATGATATCGATTGTATGCAGCAAAGTCTCGGTCCCAAGAGTCCCCAGAAGCGTAGTCGCGTCTGCGAAATGTTTCACACACACCTGCAAAAGTTTCAGCTGCACGAGCTGGCCAAATATGTGCAAACCTATATCACCGAACAACAGTTGCCACTACCTGGAAGACAGCGGCTTAATCGACTGCATCGCTCGGACTATCCTGAACTCTGCGATGTGCGCATCGTTTGCGAGGATGGTGAAGTGCTGGAGGcgcacaaatgcattttggtgGCGCGTCTCGAATACTTTGAGATGATGTTCATGCACTCCTGGGCCGAGCGCACCACCGTCACTTTTGACGGAGTGCCAGCTGAGTATATGGAGCCAGTGCTCGATTATCTGTATAGCCTGGACACGGAGGCATTTTGCAAGCAAAACTATACGGAAACGTTCCTGTACAATATGATTACGCTATGcgatcaatattttattgagtCGCTGCAGAACGTATGTGAATCCTTAATACTGGACAAGATTAGCATACGCAAGTGCGGCGAGATGCTCGACTTTGCCGTCATGTACAACTGCAAGCTGTTGCAGCAGGGCTGCCTGGACTTCATTTGCCAGAATCTGGCGCGTGTGCTCAGCTATCGCAGCATCGAGCAGTGCGAGGCGGGCACCTTGAAGCACCTTAATGAGCATTATAGAAAGATGTTTCAATCGGTGTTTGATTACCGACAGATAACGCCCTTCTCCGAGGCCATTGAGGATGAGCTGTTGCTCAGCTTTGTCGACGGCTGCGAAGTCGATTTGGATTATCGCATGGACGCGGATGCCAAGCTAAAGGAGGCTGCCAAGCACAAGCAAAAGGAGCTGCACAATAAGCAGGATGCACGGCATTATGAGCAGCAGGCAATATCGAGCATGATGCGTTCGATAAGCATTAGTGAATCATCAGTTGATCCAGCCACTGCTGCTCAGGCCAGTTCGCCAAATGAGGCTAAGATCTGGTCGCGAGTCGTCGATAAAAAGGAGCAGAAGCGCAAGCTGGCCGAGACGGCATTAAAAGTTAACAATGTGCTCAAACAGGAGGAGCAGCCATCCCCAGAGCTAAACGTACTGTCGCCATGCTCTTTTACAGAGCGTACTCCCATTAAGGAGACAACGCCACCACTGCCACCAACCAGTCCCACCGAGTGCAGCACACCACTAAGCAAAAGCTACAATTTAGATTTAAGTACTCTTGTGCCGCAGTCACAGAAGCTCTCTCAGAAGCAGCGCAGACGTCTCTCCTCCGAGTCGCAGAGTTGGCGCGCCAATAACTCCGCACCGCTGGAGCTGAACAGCACGCCCTTGGTAGTGCCCAATGCTTGGGGAGTGACAGCCCACAGTTCGCCAACAACATATGCGGAGCCTTTTAGCTCACCGCCTGCCACCGGCAGCATCTCGGATCCCACCTCTTTTGCCAATATGATGCGTGGACAGACGCAAGCACAGGCGACGGTAGCCACTAGCGCCGATCAGGCCAACAGCTTCTCCAAGATCCTGGCCGATGAGCGGCGTCAACGCGAGACCTACGAGCGCATGCGCAACAAGTCGCTGGTGCACACCCAAATCGAGGAGACGGCCATTGCGGAGCTGCGCGAATTCTACAACGTGGACAACATTGACGACGAGACAGTCACCATTGAGCGCAAGTCGAGGCCAAGCAATATGAACTTTAGCACCTGGTTAAAGCATTGA
Protein Sequence
MLENTSSLYLPAVVSNDSKNQDYDCTVKCRRREHGNCITAALTKRSIDDQHLAAFVAKSCANFSNIHDYLGRSAVHMSASVARYKILEWLLNHGALVNERDYESGSSPLHRALYYGCIDCAVLLLRYGASLELLDEDTRCPLQAICRKCDLDPSADSQNETLVWGSNKNYNLGIGNEQNTNAPQAVDFFRKSNIWIEHVALGAYHSLFCDKKGHLYAVGHGKGGRLGIGVENSLPAPKRVKVPLKQSDERIICISVSRQHSLVLTNRSLVFACGVNDNQQLGVRDAGEQLTTFKEVVSLRDKSATGLLRVIACDQHSIAYSSKCIYVWGANQGQFGISAKTKTIVSPTQMKLAERTHIRFVEANNAATVVYTEEKLILLFYADKPRTIKTPNYEDLKSIAVIGGNLKNSAKGSAVALKLMMLTETNVVFLWYENTQQFYRCNFAPIRMPEIKRILYKCNQVLVLSMDGCVYRGKCNQLALPAESAQDKPKANVDIWQNNDQNRTEISREHYVRIDLQRVPNIDRAVDIVCDESFTSFAVLQESHMKYFRKPTLPRREHSFKKLYHDTSESDAVHDIIFHVDGELFAAHKFIIFNRAAGLRELVRLYLDKDIYLNFENLTGKMFELVLKHIYTNYWPTEDDIDCMQQSLGPKSPQKRSRVCEMFHTHLQKFQLHELAKYVQTYITEQQLPLPGRQRLNRLHRSDYPELCDVRIVCEDGEVLEAHKCILVARLEYFEMMFMHSWAERTTVTFDGVPAEYMEPVLDYLYSLDTEAFCKQNYTETFLYNMITLCDQYFIESLQNVCESLILDKISIRKCGEMLDFAVMYNCKLLQQGCLDFICQNLARVLSYRSIEQCEAGTLKHLNEHYRKMFQSVFDYRQITPFSEAIEDELLLSFVDGCEVDLDYRMDADAKLKEAAKHKQKELHNKQDARHYEQQAISSMMRSISISESSVDPATAAQASSPNEAKIWSRVVDKKEQKRKLAETALKVNNVLKQEEQPSPELNVLSPCSFTERTPIKETTPPLPPTSPTECSTPLSKSYNLDLSTLVPQSQKLSQKQRRRLSSESQSWRANNSAPLELNSTPLVVPNAWGVTAHSSPTTYAEPFSSPPATGSISDPTSFANMMRGQTQAQATVATSADQANSFSKILADERRQRETYERMRNKSLVHTQIEETAIAELREFYNVDNIDDETVTIERKSRPSNMNFSTWLKH

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00499681; iTF_00500417; iTF_00514273; iTF_00498978; iTF_00521506; iTF_00485956; iTF_00522308; iTF_00577156; iTF_00593221; iTF_00616294; iTF_00543847; iTF_00525256; iTF_00497513; iTF_00498249; iTF_00518539; iTF_00558828; iTF_00560396; iTF_00553133; iTF_00501904; iTF_00564752; iTF_00607184; iTF_00557298; iTF_00482355; iTF_00574164; iTF_00583060; iTF_00513560; iTF_00570492; iTF_00598972; iTF_00496733; iTF_00548925; iTF_00566909; iTF_00596029; iTF_00610013; iTF_00619965; iTF_00495231; iTF_00535423; iTF_00552415; iTF_00597503; iTF_00528160; iTF_00490881; iTF_00534680; iTF_01327265; iTF_01321288; iTF_01327989; iTF_00589634; iTF_00559587; iTF_00551684; iTF_00549648; iTF_01356229; iTF_00472455; iTF_00562567; iTF_00553805; iTF_00595344; iTF_00556606; iTF_00506215; iTF_00598248; iTF_00582345; iTF_00617001; iTF_00563270; iTF_00475313; iTF_00526679; iTF_00550987; iTF_00573419; iTF_00479575; iTF_00802955; iTF_00473164; iTF_00516364; iTF_00509198; iTF_00614289; iTF_00520731; iTF_00531054; iTF_00561134; iTF_00476721; iTF_00567633; iTF_00547453; iTF_00541855; iTF_00511379; iTF_00572692; iTF_00579381; iTF_00806069; iTF_01320565; iTF_00510646; iTF_00495959; iTF_00519255; iTF_00530360; iTF_00576440; iTF_01325017; iTF_00532474; iTF_00533914; iTF_00508443; iTF_00493053; iTF_00502621; iTF_00517088; iTF_00588928; iTF_00901600; iTF_01323488; iTF_01325760; iTF_01570336; iTF_01570337; iTF_01322025; iTF_01324233; iTF_01326509; iTF_01322745; iTF_00538320; iTF_00803701; iTF_00805291; iTF_00601914; iTF_00585313; iTF_00608546; iTF_00558019; iTF_00583785; iTF_00610756; iTF_00537606; iTF_00478826; iTF_00569072; iTF_00470969; iTF_00528909; iTF_00575693; iTF_00506978; iTF_00523055; iTF_00586065;
90% Identity
iTF_00499681; iTF_00500417; iTF_00514273; iTF_00498978; iTF_00521506; iTF_00485956; iTF_00522308; iTF_00577156; iTF_00593221; iTF_00543847; iTF_00525256; iTF_00497513; iTF_00518539; iTF_00558828; iTF_00560396; iTF_00501904; iTF_00564752; iTF_00557298; iTF_00482355; iTF_00574164; iTF_00583060; iTF_00513560; iTF_00570492; iTF_00496733; iTF_00548925; iTF_00566909; iTF_00596029; iTF_00610013; iTF_00619965; iTF_00495231; iTF_00535423; iTF_00552415; iTF_00597503; iTF_00528160; iTF_00616294; iTF_00498249; iTF_00607184; iTF_00511379; iTF_00576440; iTF_00598972; iTF_00553133; iTF_00517088; iTF_01325760; iTF_01327265; iTF_01322025; iTF_01324233; iTF_01326509; iTF_01327989; iTF_01321288; iTF_01322745; iTF_01325017; iTF_01323488;
80% Identity
-