Dqui019816.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Drosophila quinaria
Gene Symbol
Ibtk
Assembly
GCA_035047525.1
Location
JAWNPO010000554.1:1639955-1647362[+]

Transcription Factor Domain

TF Family
BTB
Domain
zf-C2H2|ZBTB
PFAM
PF00651
TF Group
Zinc-Coordinating Group
Description
The BTB (for BR-C, ttk and bab) [6] or POZ (for Pox virus and Zinc finger) [1] domain is present near the N-terminus of a fraction of zinc finger (Pfam:PF00096) proteins and in proteins that contain the Pfam:PF01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerisation and in some instances heteromeric dimerisation [1]. The structure of the dimerised PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule [2]. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT [5, 3, 4]. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 3 3.8e-07 0.0001 22.8 0.1 7 78 555 622 549 669 0.88
2 3 2.2e-14 5.8e-12 46.1 1.1 8 107 688 792 681 795 0.86
3 3 0.93 2.5e+02 2.2 0.3 62 109 781 826 770 827 0.80

Sequence Information

Coding Sequence
ATGTCGGCATTGAAAAACCAGGAATATGACTGCACCGTCAAGTGCCGGCAACGTCAGCATGGCAACAGCATTACGGCCGCGATCACAAAACGTTCAATTGACGATCAAAATTTGGCCGCATTTATTGCCAAAActtgtgcaaatttcagcaaTATACGGGATTATCTCGGTCGCTCAGCGGTTCATATGTGTGCCTCCGTGGCCCGCTACAAAATCCTCGAATGGCTATTGAATCACGGTGCCCAGATCGATATACGTGACCACGAGTCGGGCAGCAGTCCACTTCATCGTGCTCTGTTTTACGGCTGCATCGACTGcgccgtgttgttgttgcgctaCGGCGCCAGCTTGGAACTGTTGGATGAGGACACGCGTTGTCCGCTGCAGGCCATCTGTCGGAAGTGGGATGACGCCGATGCCACGATGTCGCAAAATGAAATTCTCGTCTGGGGCTCGAATAAGAACTACAATCTGGGCATTGGCAACGAGCAGAGCTCGAATTCGCCGCAGGCGGTCGACTTCTTTCGTAAGTCCAATCTCTGGATCGAGCATGTGGCCCTCGGCGCCTATCACAGCCTCTTCTGCGACAACAAGGGGCATCTGTACGCCGTGGGACACGGCAAGGGCGGCAGACTGGGCATTGGTGTGGAGAACAGTTTGCCGGCCCCAAAAAGAGTCAAGGTGCCACTGAAGAATGGCAACATGGAGCACATCATCTGCTTGAGTGTCTCCCGACAGCATTCGCTGCTGTTGACGAATCGCTCTTTGGTCTTTGCCAGCGGCGTCAATGATAATCATCAGTTGGGTGTCCGCGATGCGGGCGACAGTCTGGCCACCTTCAAGGAAGTCGTCGCATTGCGTGACAAAGGCGCCCACGATTTAATCCGCGTCATTGCCTGCGATCAGCATTCCATTGCCCACAGCTCCAAGTGCATCTTTGTCTGGGGCGCCAATCAGGGACAATTCGGCATCAGTGCGCAGACGAAAACGATACTGGCGCCAACATTGATGAAACTCGCAGAGCGCACAACCATCGGATTTGTGGAGGCGAATAATGCAGCCACTGTTGTTTACTCAACGGAAAAACTGATATTCCTGTTCTACGCGGACAAAACGAGAACTATAAAGACACCCAACTACGAGGATCTCAAAAGCATTGCTGTGATGGGCGGCAACATCAAGAACTCCACAAAAGGATCCGCAGCAGCTCTAAAACTATTGATGCTCACCGAAACGAATGTGGTTTTCATTTGGTACGAGAATACACAACAGTTTTACAGttgcaatttctCGCCCATTCGTCTGCCGGAGATCAAGCAGATTCTGTACAAGTGCAATCAAGTGTTGATTCTCTCGGATGGCTGTGTCTATCGCGGCAAGTGCAATCAACTCACGTTTCCCGCTGGCAGTCAGGATAAACCGAAGCACAATCTGGATATTTGGCAAAACAACGATCAGAATCGCACGGAAATCTCGAGAGAACATTTTATACGCATCGATTTGCAGCGTGTGCCGAATATTGATCGTGCCGTCAACATTGTTTGCGATGAGAGTTTCTCCTCGTTTGCCGTGCTCCAGGAATCGCACATGAAGTACTTCAAGAAACCAACGTTGCCACGTCGAGAGCATCATTTTAAGAAGCTCTATCACGACACCTGCGATTCGGATGCAGTCCATGACGTTGTGCTCCATGTGGACGGTGAAAGATTTGCCGCACACAAGTTTATCATCTTTAGTCGTGCACCAGGACTAAGGGAATTAATTCGTTGTTATTTGGACAAGAATGTCTATTTGAACTTTGATAATCTGACTGGCAAAATGTTTGAGCTGATTTTAAAGCATATTTACTGCAATTATTGGCCCACAGAAGATGATATCGACTGCATGCAACAGAGTTTGGGTCCAAATAAACCGCAAAAGCGTAAACGTGTCTGCGAAATGTTTCACACTCACCTGGAAAAGTTCCAGTTGCAGGAATTGGCTAAATATGTGCAGAGCCACATCAGCGAGGGACAGTTTCCTTTGCCGAGTCGACAACGTTTCAATCGTTTGCAGCGCACGAATTTCCCGGATCTCTACGATGTGCGCATTGTGTGCGAGGAGGGCGAAGTGCTGGAGGCGCACAAATGTGTCCTGGTGTCGCGTCTGGAGTACTTCGAGATGATGTTCATGCACTCGTGGGCGGAACGGGCCACAGTCAACTTTGACAGCGTGCCCGTGGAGTATATGGAACCCATTCTCGATTATTTGTATAGTCTGGACACGGAGgcattttgtaaacaaaactaTACGGAAACATTTCTATATAATATGATAACGCTGTGCGATCAGTACTTTATTGAATCGCTGCAGAATGTGTGTGAATCATTGATTCTGGACAAGATTAGCATTAGGAAGTGCGGCGAGATGTTGGACTTTGCCGTCATGTACAACTGCCGGCTGCTGCAGGAAGGCTGCCTCGACTTTATCTGCCAGAATTTGGCACGTGTTCTCACCTATCGCAGCATCGAGCAGTGCGAGGCAACGACTCTGCATCTCCTCAACGATCATTACCGGAAAATGTTCCACACGGTGTTTGACTATCGTCAAATCACACCCTTCTCAGAGGCTATAGACGACGAGCTGCTGCTCAGCTTTGTCGATGGATGCGAAGTGGATTTGGAGTATCGTATGGTTGTGGATGCCAAGCTGAAGGACTCCGCTCGGTCGAAGCAAAAGGAGCTGCACAACAAACAGGATGCGCATCACTATGAACAGCAGGCCATCTCCAGCATGATGAGATCCCTGAGTGTGAGCGAATCCTCGCCAGAACAACAGGCAGCAGCTCAAGAAAGCAGCCCAAACGAGGCTAAAAATTGGTCACGAGTTGTCGACAAAAAGGAACAGAAACGCAAGTTGGCCGGCGAGACGGCATTAAAGGTCAACAATATGCTGAAACAGGAGGAGCAGCCGAGTCCCGAACTTGTAGTCATGTCACCACGAACGCCTGGCAAGGAGCAAACACTGCCAAACAGTCCCACCGAGGTCAGCACACCTTTAAGCAAGAGTTACAATCTAGATCTGAGCACATTGATGGGACAATCGCAGAAACTGTCGCAGAAACAGCGCAAACGTCTCAGCTCGGAGACACAGAGTTGGCGTGCCGGCAACAGCTCGGCAACATTGGAACTGAGTGCTCCAGCTGCTCCTCCCAATGCTTGGGGTGTtgtcaactccaactccaactccaattcAAGTGCAACTTATCCAGAGGCTTTTAGTTCGCCGCCAGCCACGGGCAGCATTACCGATCCCACCTCCTTTGCCAATATGATGCGTGGACAATCGACTTCagctacagcagcaacaactgcagccgATCAGGGCAATAGCTTCTCCAAGATCCTGGCGGATGAGCGACGCCAGCGTGAGAGCTACGAACGCATGCGCAATAAATCTCTAGTCCATACCCAGATCGAGGAGACGGCGATTGCCGAGCTGCGCGAATTCTACAACGTGGATAAAATCGATGACGAGACAATCACAATCGAACGCAAATCGCGGCCCAGCAATATTAACTTTAGCACCTGGTCAAGACATTGA
Protein Sequence
MSALKNQEYDCTVKCRQRQHGNSITAAITKRSIDDQNLAAFIAKTCANFSNIRDYLGRSAVHMCASVARYKILEWLLNHGAQIDIRDHESGSSPLHRALFYGCIDCAVLLLRYGASLELLDEDTRCPLQAICRKWDDADATMSQNEILVWGSNKNYNLGIGNEQSSNSPQAVDFFRKSNLWIEHVALGAYHSLFCDNKGHLYAVGHGKGGRLGIGVENSLPAPKRVKVPLKNGNMEHIICLSVSRQHSLLLTNRSLVFASGVNDNHQLGVRDAGDSLATFKEVVALRDKGAHDLIRVIACDQHSIAHSSKCIFVWGANQGQFGISAQTKTILAPTLMKLAERTTIGFVEANNAATVVYSTEKLIFLFYADKTRTIKTPNYEDLKSIAVMGGNIKNSTKGSAAALKLLMLTETNVVFIWYENTQQFYSCNFSPIRLPEIKQILYKCNQVLILSDGCVYRGKCNQLTFPAGSQDKPKHNLDIWQNNDQNRTEISREHFIRIDLQRVPNIDRAVNIVCDESFSSFAVLQESHMKYFKKPTLPRREHHFKKLYHDTCDSDAVHDVVLHVDGERFAAHKFIIFSRAPGLRELIRCYLDKNVYLNFDNLTGKMFELILKHIYCNYWPTEDDIDCMQQSLGPNKPQKRKRVCEMFHTHLEKFQLQELAKYVQSHISEGQFPLPSRQRFNRLQRTNFPDLYDVRIVCEEGEVLEAHKCVLVSRLEYFEMMFMHSWAERATVNFDSVPVEYMEPILDYLYSLDTEAFCKQNYTETFLYNMITLCDQYFIESLQNVCESLILDKISIRKCGEMLDFAVMYNCRLLQEGCLDFICQNLARVLTYRSIEQCEATTLHLLNDHYRKMFHTVFDYRQITPFSEAIDDELLLSFVDGCEVDLEYRMVVDAKLKDSARSKQKELHNKQDAHHYEQQAISSMMRSLSVSESSPEQQAAAQESSPNEAKNWSRVVDKKEQKRKLAGETALKVNNMLKQEEQPSPELVVMSPRTPGKEQTLPNSPTEVSTPLSKSYNLDLSTLMGQSQKLSQKQRKRLSSETQSWRAGNSSATLELSAPAAPPNAWGVVNSNSNSNSSATYPEAFSSPPATGSITDPTSFANMMRGQSTSATAATTAADQGNSFSKILADERRQRESYERMRNKSLVHTQIEETAIAELREFYNVDKIDDETITIERKSRPSNINFSTWSRH

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00542537;
90% Identity
iTF_00601914; iTF_00523055; iTF_00506978; iTF_00575693; iTF_00528909; iTF_00586065; iTF_00519255; iTF_00510646; iTF_00558019; iTF_00608546; iTF_00583785; iTF_00537606; iTF_00533914;
80% Identity
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