Dsia006546.1
Basic Information
- Insect
- Drosophila siamana
- Gene Symbol
- Ibtk
- Assembly
- GCA_035047445.1
- Location
- JAWNPP010000020.1:1315525-1319842[-]
Transcription Factor Domain
- TF Family
- BTB
- Domain
- zf-C2H2|ZBTB
- PFAM
- PF00651
- TF Group
- Zinc-Coordinating Group
- Description
- The BTB (for BR-C, ttk and bab) [6] or POZ (for Pox virus and Zinc finger) [1] domain is present near the N-terminus of a fraction of zinc finger (Pfam:PF00096) proteins and in proteins that contain the Pfam:PF01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerisation and in some instances heteromeric dimerisation [1]. The structure of the dimerised PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule [2]. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT [5, 3, 4]. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 3 6.6e-06 0.0015 18.5 0.3 8 78 555 621 548 668 0.88 2 3 3.1e-14 7.1e-12 45.3 1.2 9 107 690 791 683 794 0.89 3 3 1.7 3.9e+02 1.1 0.1 82 109 798 825 792 826 0.86
Sequence Information
- Coding Sequence
- ATGTCAGCGCTAAAAAACCAGGAATACGACTGCACAATCAAGTGCAGGAAACGTCAACATGGTAACAGCATTACGGCGGCACTTACAAAACGCTCTATTGACGATCAGCAATTAGCCGCATTTATTGCCAAAACTTGCGCGAATTTCAGCAATATACGCGACTATCTAGGCCGCTCCGCTGTGCATATGTGCGCCTCCGTGGCACGCTACAGAATACTAGAGTGGCTTCTCAATCACGGTGCTCACATCGACGAACGCGATTACGAATCAGGCAGCAGTCCATTGCATCGAGCGTTGTACTACGGCTGCATCGAttgtgctgtgttgctgttgcgttaTGGCGCCAGTGTGGACCTGCTGGATGAGGACACGCGCTGTCCGCTGCAAGCCATCTGCCGCAAATGGGATGTGGAGCCAACGACTTCGTCACAAAATGAAATCCTGGTCTGGGGTTCGAATAAGAACTATAACCTGGGCATTGGCAATGAGCAGAATACGAATTCACCGCAGGCGGTGGATTTCTTCCGCAAATCGAATTTGTGGATCGAGCGCATGGCGCTGGGCGCCTATCACAGTCTTTTCCTCGACAGCAAGGGTCATCTCTATGCCGTGGGCCATGGCAAGGGCGGACGCCTGGGCATTGGCGTGGAGAACAGCTTGCCGGCGCCAAAGCGTGTGAAAGTCCCACTGAAGCAGGCCAACGAACATATCATCTGCCTCAGCGTCTCCAGACAGCATTCGCTGCTGCTTACAAATCGTTCACTAGTCTTTGCCTGTGGTGTGAATGACAACCATCAACTGGGCGTGCGTGATGCTGGCGAAAGTCTGGCCAAGTTCAAGGAAGTTGTCTCGCTACGTGACAAAGGCGCCAGCGATTTGCTACGTGTTATTGCCTGTGATCAGCATTCCATTGCCTACAGCTCTAGGTGCATCTATGTGTGGGGTGCCAATCAGGGACAGTTTGGCGTCAGTGCGCATACCAAGACGATAATGGCGCCCACATTGATGAAGCTTCCGGATCGCACGTCCATCAACTTTGTGGAGGCGAATAATGCAGCCACCGTGGTCTATACAACGGAGAAGCTGATATTCTTGTTCTATGCGGACAAAACTAGAACCATAAAGACGCCCAACTATGAAGATCTCAAAAGCATTGCGGTGATGGGCGGCAACATTAAGAACTCCGCTAAAGGCTCCGCTGCAGCTCTTAAGCTTTTGATGCTCACGGAGACGAATGTGGTGTTCCTCTGGTACGAGAACACGCAACAGTTCTACATcTGCAATTTCTCGCCTATACGTGTGCCAGAGGTAAAGAAGATCGTCTACAAGTGCAATCAAGTCCTAATACTCTCCGACGGCTGCGTCTATCGCGGCAAATGCAATCAGCTGGCCTTTCCCGCCGGCAGTCAGGAGAAGCCGAAGCACAACATGGACATCTGGCAAAATAACGATCAGAATCGCACGGAAATCTCTAGGGAACACTATGTACGCATCGATCTGCAGCGTGTGCCGAACATCGATCGGGCTGTGGACATTGTTTGTGATGAGAGTTTCTCCTCGTTTGCTGTGCTCCAAGAATCGCACATGAAGTATTTCCGCAAGCCAACGTTGCCACGTCGCGAGTACCACTTCAAAAAGCTCTATCACGACACCTGCGATGCGGATGCGGTGCATGATGTGGTGTTTCATGTGGACAGCGAAAGTTTTGCCGCTCACAAGTTTATCATCTACAGTCGGGCTCCAGGCTTGCGCGAGCTTATACGTTGCTATCTCGATAAGAATGTCTATTTGAACTTTGAAAGTTTGACGGGAAAAATGTTTGAGCTGGTGCTGAAGCACATCTACAGCAACTACTGGCCAACAGAGGATGATATTGACTGCATGCAGCAGAGTCTGGGCCCAAACAAGCCGCAGAAGCGCAGTCGCGTTTGTGAAATGTTTCTCACTCACTTGGTCAAATTCCAGCTGCAGGAGCTGGCCAAATATGTGCAGAGTTACATAATGGAGCAACAGTTCCCCCTGCCCAATAGGCAGAGATTCAGTCGCATGCACCGCACAGATTTCCCAGAACTCTACGATGTAAACATCGTTTGCGAGGAGGGCGAAGTGTTGGAGGCGCACAAGTGCGTCTTGGTGGCGCGTCTCGAGTACTTTGAGATGATGTTTATGCATTCCTGGGCAGAGCGTACCACCATTAACTTCGAGACCGTGCCCGTGGAGTACCTGGACCCAATACTCGACTATCTCTACAGCCTGGACGCGGAGGCGTTTTGCAAGCAAAACTATTCGGAAACGTTTCTCTACAATATGATTACGTTGTGCGATCAGTATTTTATTGAATCGTTGCAGAATGTTTGCGAATCGTTAATTCTTGACAAGATTAGCATACGCAAATGCGGAGAGATGTTGGACTTTGCTGCGATGtacaattgcaaaatattgaaGCAGGGCTGCCTCGATTTTATCTGCCAAAATCTGGCACGTGTGCTCACCTATCGCAGCATCGAGCCGTGCGAAGCGAGCACGTTGCATCTGCTTAACGAGCACTATCGCAAGATGTTCAAGACTGTGTTTGACTATCGTCAAATCACACCCTTCTCAGAGGCTATAGAGGATGAGCTGTTGCTCAGCTTTGTTGATGGTTGCGAGGTCGATTTGGATTATCGCATGAGTGCGGATGGCAAGCTCAAGGAGGCTgcgcgacaaaaacaaaaggagcACAATAAACAAGATGCACATCACTATGAAAAACAGGCAATTTCAAGTATGATGCGATCGCTAAGCATCAGTGAATCCGCTGCATCGCCAGCCGATCAGCAGACTACAACACAAGCTACCTCGCCCACTGAGGTCAAGAACTGGTCGCGAGTCGTCGACAAAAAGGAACAGAAACGCAAGCTGGCAGAGACGGCGCTGAAGGTCAACAATGTTCTCAAGCAGGAGGAGCTACCCAGCCCAGAACTGGTTGTCATGTCGCCACGCAGCTATATCGAAAAAACGCCTGTAAAAGAACAAACGCCACCACTGCCAATCAGTCCAACGGAGGCCAGCACGCCCATCAGCAAGAGCTACAATTTGGATCTTAGCTCACTGGTGCCTCAGTCCCAGAAGCTGTCACAGAAGCAGCGTAAACGTTTGTCCTCCGAGTCGCAGAGCTGGCGCGCCAACAGCTCAGCCACACTGGAGTCAAGCCCGACGCCCGTGGCTATGCCCAATGCCTGGGGCGTCGCCACCATCTCGCCCGCCACTTACCCAGAGTCGGCGTTTAGCTCGCCTGTCGCCACGGGCAGCAGTGCAGATCCCACCTCATTTGCGAATATGATGCGTGGACAGGCGGCTGCGTCTGCAACTGTGCCAGCAGATCAAAGAAATAGTTTCTCCAAGATCTTAGCCGACGAGCGACGTCAGCGCGAGAGCTACGAGCGAATGCGCAACAAATCTCTAGTCCATACCCAAATTGAAGAGACGGCAATTGCAGAACTGCGTGAGTTCTACAACGTGGACAAAATTGACGACGAAACCATCACCATTGAGCGCAAGTCTAGACCAAGTGACATTAATTTTAGCACCTGGTCGAGACATTAA
- Protein Sequence
- MSALKNQEYDCTIKCRKRQHGNSITAALTKRSIDDQQLAAFIAKTCANFSNIRDYLGRSAVHMCASVARYRILEWLLNHGAHIDERDYESGSSPLHRALYYGCIDCAVLLLRYGASVDLLDEDTRCPLQAICRKWDVEPTTSSQNEILVWGSNKNYNLGIGNEQNTNSPQAVDFFRKSNLWIERMALGAYHSLFLDSKGHLYAVGHGKGGRLGIGVENSLPAPKRVKVPLKQANEHIICLSVSRQHSLLLTNRSLVFACGVNDNHQLGVRDAGESLAKFKEVVSLRDKGASDLLRVIACDQHSIAYSSRCIYVWGANQGQFGVSAHTKTIMAPTLMKLPDRTSINFVEANNAATVVYTTEKLIFLFYADKTRTIKTPNYEDLKSIAVMGGNIKNSAKGSAAALKLLMLTETNVVFLWYENTQQFYICNFSPIRVPEVKKIVYKCNQVLILSDGCVYRGKCNQLAFPAGSQEKPKHNMDIWQNNDQNRTEISREHYVRIDLQRVPNIDRAVDIVCDESFSSFAVLQESHMKYFRKPTLPRREYHFKKLYHDTCDADAVHDVVFHVDSESFAAHKFIIYSRAPGLRELIRCYLDKNVYLNFESLTGKMFELVLKHIYSNYWPTEDDIDCMQQSLGPNKPQKRSRVCEMFLTHLVKFQLQELAKYVQSYIMEQQFPLPNRQRFSRMHRTDFPELYDVNIVCEEGEVLEAHKCVLVARLEYFEMMFMHSWAERTTINFETVPVEYLDPILDYLYSLDAEAFCKQNYSETFLYNMITLCDQYFIESLQNVCESLILDKISIRKCGEMLDFAAMYNCKILKQGCLDFICQNLARVLTYRSIEPCEASTLHLLNEHYRKMFKTVFDYRQITPFSEAIEDELLLSFVDGCEVDLDYRMSADGKLKEAARQKQKEHNKQDAHHYEKQAISSMMRSLSISESAASPADQQTTTQATSPTEVKNWSRVVDKKEQKRKLAETALKVNNVLKQEELPSPELVVMSPRSYIEKTPVKEQTPPLPISPTEASTPISKSYNLDLSSLVPQSQKLSQKQRKRLSSESQSWRANSSATLESSPTPVAMPNAWGVATISPATYPESAFSSPVATGSSADPTSFANMMRGQAAASATVPADQRNSFSKILADERRQRESYERMRNKSLVHTQIEETAIAELREFYNVDKIDDETITIERKSRPSDINFSTWSRH
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- iTF_00542537;
- 90% Identity
- iTF_00589634; iTF_00472455; iTF_00562567; iTF_00553805; iTF_00556606; iTF_00520731; iTF_00509198; iTF_00614289;
- 80% Identity
- -