Dmea019554.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Drosophila melanica
Gene Symbol
Dp
Assembly
GCA_004143765.1
Location
SCDT01000008.1:21296-26672[-]

Transcription Factor Domain

TF Family
E2F
Domain
E2F_TDP domain
PFAM
PF02319
TF Group
Helix-turn-helix
Description
This family contains the transcription factor E2F and its dimerisation partners TDP1 and TDP2, which stimulate E2F-dependent transcription. E2F binds to DNA as a homodimer or as a heterodimer in association with TDP1/2, the heterodimer having increased binding efficiency. The crystal structure of an E2F4-DP2-DNA complex shows that the DNA-binding domains of the E2F and DP proteins both have a fold related to the winged-helix DNA-binding motif. Recognition of the central c/gGCGCg/c sequence of the consensus DNA-binding site is symmetric, and amino acids that contact these bases are conserved among all known E2F and DP proteins.
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 1 7.5e-24 5.1e-20 71.1 0.3 2 65 178 253 177 253 0.97

Sequence Information

Coding Sequence
ATGGCGCATACCTCGGCCACAAATCAAACGAGCGGCGCTGTGAAGACGGATGAAGTCAACTATTTCTTTCAGGATGAGCACGgacaaattgcaaaaatgctGAAGCCAATGCAAGTGAAGCAAGCACAATCCATGGACAACTCAAAGTCAAGTTTGGTCTTTCCCAGCGGTTCTACACGCAACGGCgggggcagcagcagtggcggTTTCGGAAATGTGGGCCGAATGGGGGCATTCAGCCAGATGAGCACAGCGAATCAGGGACAATTCATTCGTGTCCAGGACGGCTGTATAACAATTCCAAAAACCGATAATAGTTCATATACACCTGTGTCAGTGCAGAAAGGCAGTGGTACTGGAGGAGGAGGCGGCGGCATTCACGAGGTGaTAAAAAACGAGCGATATGTCAAATATACGCCAACTAACGCCATGAAAGTTAAATCGAAATTGCACGCCATACAGAGCAGTCCCATGCATACGATTTCCGCCTCTTCCTCGTCTGtgcaaagaaaacgaaaaccgGACAAGGCCGGCAAGGGTCTGCGTCACTTTTCGATGAAGGTGTGCGAAAAGGTGCAGGAGAAGGGCAAGACCACATACAATGAAGTTGCTGATGATTTGGTTACTGAAGAACTGAAGAACAATTCATATGATAACTGTGATCAAAAGAATATCCGGCGTCGTGTATACGATGCGCTCAACGTACTGATGGCAATCAATGTTATTTCTAAGGACAAAAAGGAAATACGTTGGATTGGTTTGCCCGCCAACTCGGCAGAGcaatttctGGCTATAGAGGAGGAGAACAATTTACGTCGTGACCGAATCAAGAAAAAAGAGGAAATGCTGCGTGAATTGGTTATGCAGCATGTGGCATTCAAGGGTCTTGTCGAGCGCAATAAACGGGCAGAGAGCCAGGGCGTGGTGCCATCACCAAACTCCTCAATTCAGTTGCCGTTCATCATTGTGAATACGCACAAATCGACAAAGATCAATTGCAGTGTCACCAACGACAAATCCGAGTACATTTTCAAGTTCGACAACACATTCGAAATGCACGACGACATCGAGGTCTTGAAACGCATGGGCCTCCTGCTGGGCTTGGATAAGGGCGAGTGCACGGGGGAGAATATTGAACGCGTCAAGGGATGGGTTCCACCAAATCTGGCCAAATATGTAGAAGCCTATGGCACTGGTAAAATGAGTGATCCGATGTACGATTCGGATGACGACACAAATGACTTCAATCAGTACCTCGAATCAACTAATGAGTCTCAAAGCTTTGCACAGCATACCACCGATGTCGAGTTTAAGCTTGAGCAGGACGATGATGAGCTCGAAGATGACATCGATTGA
Protein Sequence
MAHTSATNQTSGAVKTDEVNYFFQDEHGQIAKMLKPMQVKQAQSMDNSKSSLVFPSGSTRNGGGSSSGGFGNVGRMGAFSQMSTANQGQFIRVQDGCITIPKTDNSSYTPVSVQKGSGTGGGGGGIHEVIKNERYVKYTPTNAMKVKSKLHAIQSSPMHTISASSSSVQRKRKPDKAGKGLRHFSMKVCEKVQEKGKTTYNEVADDLVTEELKNNSYDNCDQKNIRRRVYDALNVLMAINVISKDKKEIRWIGLPANSAEQFLAIEEENNLRRDRIKKKEEMLRELVMQHVAFKGLVERNKRAESQGVVPSPNSSIQLPFIIVNTHKSTKINCSVTNDKSEYIFKFDNTFEMHDDIEVLKRMGLLLGLDKGECTGENIERVKGWVPPNLAKYVEAYGTGKMSDPMYDSDDDTNDFNQYLESTNESQSFAQHTTDVEFKLEQDDDELEDDID

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00560832; iTF_00496385; iTF_00482023; iTF_00609671; iTF_00573838; iTF_00619632; iTF_00558450; iTF_00566580; iTF_00592884; iTF_00494901; iTF_00521141; iTF_00497175; iTF_00527837; iTF_00560030; iTF_00597150; iTF_00513251; iTF_00521959; iTF_00548596; iTF_00524917; iTF_00576137; iTF_00554187; iTF_00606859; iTF_00543534; iTF_00500098; iTF_00552099; iTF_00511066; iTF_00535104; iTF_00570190; iTF_01321710; iTF_01322434; iTF_01323172; iTF_01323904; iTF_00516785; iTF_00485652; iTF_00499380; iTF_00557007; iTF_00497943; iTF_00542232; iTF_00576856; iTF_00518235; iTF_00595742; iTF_00472855; iTF_00501595; iTF_00598673; iTF_00615991; iTF_00552827; iTF_00564445; iTF_00582752; iTF_00567329; iTF_00547153; iTF_00610438; iTF_00802625; iTF_00803393; iTF_00526370; iTF_00556354; iTF_00553549; iTF_00562262; iTF_01327683; iTF_01552964; iTF_00498661; iTF_00544262; iTF_00586471; iTF_00502314; iTF_00599374; iTF_00568047; iTF_00516048; iTF_00551377; iTF_00559284; iTF_00573108; iTF_00545013; iTF_00493438; iTF_00540158; iTF_00476415; iTF_01558822; iTF_00538023; iTF_00572392; iTF_00582056; iTF_01548648; iTF_00550729; iTF_01326185; iTF_00509610; iTF_00532162; iTF_00519709; iTF_00584970; iTF_00583468; iTF_00528589; iTF_00530061; iTF_00495652; iTF_01326957; iTF_00546447; iTF_01325455; iTF_01554479; iTF_00804977; iTF_00508114; iTF_01570034; iTF_00537299; iTF_00601557; iTF_01324694; iTF_00510329; iTF_00533593; iTF_00597945; iTF_00588657; iTF_01549369; iTF_00472154; iTF_00522746; iTF_00575367; iTF_00506650; iTF_00585754; iTF_00616698; iTF_00475009; iTF_00534375; iTF_00490574; iTF_00505902; iTF_00530747; iTF_00562972; iTF_00568764; iTF_00478508; iTF_00470656; iTF_00595038; iTF_00589344; iTF_00549343; iTF_00479282; iTF_00805759; iTF_00512512; iTF_00557696; iTF_00518949; iTF_00608232; iTF_01320262; iTF_01320984; iTF_00513971; iTF_00579079; iTF_00613982; iTF_00520424; iTF_00508895; iTF_00584223; iTF_01559551; iTF_01551512; iTF_01557352; iTF_01556619; iTF_01550069; iTF_01552245; iTF_01558071; iTF_01555229; iTF_01553758; iTF_01550784; iTF_00901280; iTF_00831939;
90% Identity
iTF_00560832;
80% Identity
-