Dfun003074.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Drosophila funebris
Gene Symbol
Dp
Assembly
GCA_018901825.1
Location
JAEIFK010000682.1:2702458-2706473[+]

Transcription Factor Domain

TF Family
E2F
Domain
E2F_TDP domain
PFAM
PF02319
TF Group
Helix-turn-helix
Description
This family contains the transcription factor E2F and its dimerisation partners TDP1 and TDP2, which stimulate E2F-dependent transcription. E2F binds to DNA as a homodimer or as a heterodimer in association with TDP1/2, the heterodimer having increased binding efficiency. The crystal structure of an E2F4-DP2-DNA complex shows that the DNA-binding domains of the E2F and DP proteins both have a fold related to the winged-helix DNA-binding motif. Recognition of the central c/gGCGCg/c sequence of the consensus DNA-binding site is symmetric, and amino acids that contact these bases are conserved among all known E2F and DP proteins.
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 1 8.3e-24 4.6e-20 71.0 0.3 2 65 181 257 180 257 0.97

Sequence Information

Coding Sequence
ATGGCGCATACCTCAACCACAAATCAAACGAGTGGCGCTGTTAAGACAGATGAAGTGAACTTCTTCTTTCGGGACGAACACGGACAAATCGCCAAAATGCTGAAACCAGTGCAAGTGAAGCAATCGCAATCAATGGATCATCCAAAGTCTAGTATAGTCTTTCCCAGCAGCTCGGCACGCAACGGGGGTGGCAATAGCAGTGGTGGGATCGGAAATGTAGGCCGCGTGGGCGCTTTTAGTCAAATGAGCACAACGACGAATCAGGGACAATTCATACGTCTGCAAGATGGCTATATTACAATTCCAAAAACCGAAAATACTTCATATACCACATCTGTGTCAGCGCAGAAAGGCAGCGGCACTGGAGGAGGGGGAGGAGGCGGCGTACACGAGGTGATAAAGAGCGGGCGATATGAGAAATATACGCCAAATAATGCCATGAAAATGAAATCGAAACTGCACGCCATACAGAGCAGTCCCATGCACACAATGTCCGCCTCATCATCGTCAGTGCAAAGGAAACGAAAGCCCGATAAGGCGGGCAAGGGACTGCGTCATTTCTCGATGAAAGTGTGCGAGAAGGTGCAAGAGAAGGGCAAGACAACCTACAATGAAGTGGCTGATGATTTGGTTACCGAGGAACTAAAGAACAATTCATATGATACCAACTGTGATCAAAAGAATATCCGGCGTCGTGTCTACGATGCGCTCAACGTACTGATGGCAATCAATGTAATTTCCAAAGACAAAAAGGAAATACGATGGATTGGCTTACCCGCCAATTCAGCCGAGCAATTTCTGGCTCTTGAAGAAGAGAACAATACGCGCCGTGAACGCATTAAGCAAAAGCACGATATGCTGCGTGAATTGGTCATGCAGCATGTGGCATTCAAGGGTCTTGTCGAGCGAAATAAGCGGGCCGAGAGCCAGGGCGCGGTGCCTTCTCCAAACTCATCCATTCAGCTGCCGTTCATCATTGTGAATACGCACAAATCGACCAAGATCAATTGCAGTGTCACCAACGACAAATCCGAATACATATTTAAGTTCGACAACACATTTGAAATGCACGATGACATCGAGGTCTTAAAGCGAATGGGACTTCTGCTGGGCTTGGACAAAGGCGAGTGTACGGCGGAGAACATTGAGCGCGTCAAGGCTTGGGTGCCACCAAATCTGGCCAAATATGTGGAAGCCTATGGTACTGGTAAAATTGGGGATCCGATGTACGATTCGGATGACGATGACAATGATTTCAATTCGTACCTCGAATCAACCAATGAGTCTCAAAGCTTTGCACAACACACACAGCATACCACCGATGTCGAATTTAAGTCGGAAGTGGACGATGAGGAGCTGGAGGATGACATCGATTGA
Protein Sequence
MAHTSTTNQTSGAVKTDEVNFFFRDEHGQIAKMLKPVQVKQSQSMDHPKSSIVFPSSSARNGGGNSSGGIGNVGRVGAFSQMSTTTNQGQFIRLQDGYITIPKTENTSYTTSVSAQKGSGTGGGGGGGVHEVIKSGRYEKYTPNNAMKMKSKLHAIQSSPMHTMSASSSSVQRKRKPDKAGKGLRHFSMKVCEKVQEKGKTTYNEVADDLVTEELKNNSYDTNCDQKNIRRRVYDALNVLMAINVISKDKKEIRWIGLPANSAEQFLALEEENNTRRERIKQKHDMLRELVMQHVAFKGLVERNKRAESQGAVPSPNSSIQLPFIIVNTHKSTKINCSVTNDKSEYIFKFDNTFEMHDDIEVLKRMGLLLGLDKGECTAENIERVKAWVPPNLAKYVEAYGTGKIGDPMYDSDDDDNDFNSYLESTNESQSFAQHTQHTTDVEFKSEVDDEELEDDID