Basic Information

Insect: Drosophila lutescens
Gene Symbol: ftz-f1
Assembly: GCA_037075285.1
Location: JBAMCF010000084.1:1-12174[-]

Transcription Factor Domain

TF Family: SF-like
Domain: zf-C4|SF-like
PFAM: AnimalTFDB
TF Group: Zinc-Coordinating Group
Description: The ligand binding domain of nuclear receptor steroidogenic factor 1 (SF-1): SF-1, a member of the nuclear hormone receptor superfamily, is an essential regulator of endocrine development and function and is considered a master regulator of reproduction. Most nuclear receptors function as homodimer or heterodimers, however SF-1 binds to its target genes as a monomer, recognizing the variations of the DNA sequence motif, T/CCA AGGTCA. SF-1 functions cooperatively with other transcription factors to modulate gene expression. Phospholipids have been determined as potential ligands of SF-1. Like other members of the nuclear receptor (NR) superfamily of ligand-activated transcription factors, SF-1 has a central well conserved DNA binding domain (DBD), a variable N-terminal domain, a flexible hinge and a C-terminal ligand binding domain (LBD). [1, 8, 3, 11, 6, 5, 12, 10, 9, 2, 4, 7]
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 3 2 2.2e+04 -11.1 19.7 82 156 67 162 4 183 0.43

2 3 2.4e-19 2.6e-15 57.0 0.4 1 76 350 425 350 456 0.74

3 3 1.6e-53 1.8e-49 169.6 1.4 157 359 555 750 536 752 0.90

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	3	2	2.2e+04	-11.1	19.7	82	156	67	162	4	183	0.43
2	3	2.4e-19	2.6e-15	57.0	0.4	1	76	350	425	350	456	0.74
3	3	1.6e-53	1.8e-49	169.6	1.4	157	359	555	750	536	752	0.90

Sequence Information

Coding Sequence: ATGTTATTAGAAATGGATCAGCAACAGGCGACCGTACAGTTTATATCGTCGCTGAATATATCGCCGTTCAGCAtgcagctggagcagcagcagcagccctcCAGTCCCGCCTTGGCCGCcggtggcaacaacaacaacaatgccagcggtagcaacaacaacagcggcggcggcaccagcggcagcaacaacaccagcagcagcaacaacaacaacaataacgacAATGATGCACATGCTCTAACCAAATTCGAGCATGAGTACAATGCCTATACGTTGCAATTGGCTGGGGGCGGTGGTGGGAGTGGCGGTGTCGGTGGCAACCAGCAACACCACAGCAGccaccaccagcaacagcagcagcagcagcaacaacagcagcaacatcagcagcagcagcaagaacactaccagcagcaacaacagaatATTGCCAACAATGCCAATCAATTCAACTCCTCGTCCTACTCGTATATATACAATTTCGATTCACAGTATATATTTCCGACAGGCTATCAGGACACCACCTCCTCGCACTCGCAGCAAagcggaggaggcggtggggGCGGCGGTGGCAACCTGCTCAATGGCAGCTCCGGCGGCAGTTCCGCCGGCGGTGGCTACATGCTCCTCCCCCAGGCGGCCAGTTCCAGTGGCAATAATAACAACCAGAATGCCGGCCACATGTCCTCCGGTTCCGTGGGCaacggcagcggcggcggtggcaacAATGGCGGATCGGGCGGGGGATCCGGTCCGGGAAATCCCATGGGCGGCACGAGCGCAACGCCGGGACACGGCGGCGAGGTGATCGACTTCAAGCACCTGTTCGAGGAGCTCTGCCCCGTGTGCGGCGACAAGGTGAGCGGCTACCACTACGGCCTGCTCACCTGCGAGTCCTGCAAGGGATTCTTCAAGCGCACCGTGCAGAACAAGAAGGTCTACACCTGCGTGGCGGAGCGCTCGTGCCACATCGACAAGACGCAGCGCAAGCGGTGTCCCTACTGCCGCTTCCAGAAGTGCCTCGAGGTCGGCATGAAGCTAGAGGctgTTCGAGCGGATCGGATGCGGGGTGGACGAAACAAATTCGGACCCATGTACAAACGGGATCGGGCGCGAAAGCTGCAGGTGATGCGGCAGCGGCAGTTGGCGCTGCAAGCGCTGCGCAACTCGATGGGTCCGGACATAAAGCCAACGCCGATCTCGCCGGGCTACCAGCAAGCATATCCAAATATGAACATTAAGCAGGAAATTCAAATACCTCAGGTATCCTCACTCACCCAATCTCCGGATTCGTCGCCCAGCCCCATAGCGATTGCGTTGGGACAGGTGAACGCGAGCACGGGCGGTGTGATAGCCACGCCCATGAACGCCGGCAACGGCGGCAGTGGGGGCGGAGGTCTCAACGGGCCCAGTTCCGTGGGCAATGGCAATAGtagcaacggcagcagcagcggcaacaacaacagcagcacgGGCAACGGAGCgtccggcggaggaggaggtggcaaCAATGcgggcggcggaggaggaggcaccAATTCCGTGGATGGCCTGCATCGCAACGGCGGCAATGGCAACAGCAGTTGCCACGAGGCTGGAATAGGATCTCTGCAAAACACGGCCGACTCGAAATTGTGcttCGATTCTGGCACACATCCATCGAGCACAGCTGACGCGCTAATCGAGCCATTGAGAGTCTCACCGATGATTCGTGAATTTGTGCAATCGATCGACGATCGGGAATGGCAGACGCAACTCTTTGCCCTGCTGCAGAAGCAAACCTACAACCAAGTGGAGGTGGATCTCTTCGAGCTGATGTGCAAAGTGCTCGACCAGAACTTATTCTCGCAAGTGGACTGGGCACGAAACACCGTCTTCTTCAAGGATCTGAAGGTCGATGACCAAATGAAGCTGCTGCAGCATTCCTGGTCGGACATGCTGGTTCTGGATCACCTGCATCATCGAATCCACAACGGCCTGCCCGATGAGACGCAACTGAACAATGGTCAGGTGTTTAATCTGATGAGCCTGGGATTGTTGGGTGTGCCACAGCTGGGCGACTACTTCAACGAGTTGCAGAATAAGCTGCAAGATCTGAAATTCGATATGGGCGACTATGTCTGCATGAAATTCCTAATCCTGTTGAATCCAAatgtACGGGGTATTGTCAACCGGAAGACCGTCTCCGAGGGACATGATAATGTGCAAGCAGCTCTGCTGGACTACACCCTCACCTGCTATCCGTCAGTCAAT
Protein Sequence: MLLEMDQQQATVQFISSLNISPFSMQLEQQQQPSSPALAAGGNNNNNASGSNNNSGGGTSGSNNTSSSNNNNNNDNDAHALTKFEHEYNAYTLQLAGGGGGSGGVGGNQQHHSSHHQQQQQQQQQQQQHQQQQQEHYQQQQQNIANNANQFNSSSYSYIYNFDSQYIFPTGYQDTTSSHSQQSGGGGGGGGGNLLNGSSGGSSAGGGYMLLPQAASSSGNNNNQNAGHMSSGSVGNGSGGGGNNGGSGGGSGPGNPMGGTSATPGHGGEVIDFKHLFEELCPVCGDKVSGYHYGLLTCESCKGFFKRTVQNKKVYTCVAERSCHIDKTQRKRCPYCRFQKCLEVGMKLEAVRADRMRGGRNKFGPMYKRDRARKLQVMRQRQLALQALRNSMGPDIKPTPISPGYQQAYPNMNIKQEIQIPQVSSLTQSPDSSPSPIAIALGQVNASTGGVIATPMNAGNGGSGGGGLNGPSSVGNGNSSNGSSSGNNNSSTGNGASGGGGGGNNAGGGGGGTNSVDGLHRNGGNGNSSCHEAGIGSLQNTADSKLCFDSGTHPSSTADALIEPLRVSPMIREFVQSIDDREWQTQLFALLQKQTYNQVEVDLFELMCKVLDQNLFSQVDWARNTVFFKDLKVDDQMKLLQHSWSDMLVLDHLHHRIHNGLPDETQLNNGQVFNLMSLGLLGVPQLGDYFNELQNKLQDLKFDMGDYVCMKFLILLNPNVRGIVNRKTVSEGHDNVQAALLDYTLTCYPSVN

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00581562;
90% Identity: iTF_00536825; iTF_00578569; iTF_00578596; iTF_00504717; iTF_00504740; iTF_00581562; iTF_00581588; iTF_00548095; iTF_00548120;
80% Identity: iTF_00536825;