Basic Information

Transcription Factor Domain

TF Family: MBD
Domain: MBD domain
PFAM: PF01429
TF Group: Unclassified Structure
Description: The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 3 0.094 1.5e+02 2.1 0.1 33 72 145 184 127 189 0.82

2 3 2.9 4.6e+03 -2.7 0.0 34 50 199 215 190 216 0.78

3 3 9e-09 1.4e-05 24.5 0.0 10 58 253 292 245 313 0.82

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	3	0.094	1.5e+02	2.1	0.1	33	72	145	184	127	189	0.82
2	3	2.9	4.6e+03	-2.7	0.0	34	50	199	215	190	216	0.78
3	3	9e-09	1.4e-05	24.5	0.0	10	58	253	292	245	313	0.82

Coding Sequence: ATGGCTGCCGCGTCCGCTggccaacagctgcagcagcaacagcagcagcagcaacaacagacgcAGCACAAATTGAACATTGTTGGTGTTGGCAATGCGGAGACGGTTGCTGGTGTGCTGCAGGTCAACAAtgagttgcaacagcaacagcaacagctcaaCATgtacaagcaacagcagcaacagcaattgttgcagcaacagcaacagcaattctATCAGCAGCAAACGAAATTTGTATCGCGGGTCGTTACAAATGCAGCCGCAATGCaatcccaacaacaacagcaacagcagcaacaaatattacCAGCTGGTTTGGTAAATGGCAGCACCAACATGATGCAAGCCACAAATGTtgctgtgcagcagcagcagcaacaacaacaacaacaacagcagcagcaaccacaacaactgcGGCATAGTCaacacatttttgtgtgtccATCAATAGGAacacagctacagcaacagcaacagcagcagcagcaacttcaacagcagcagcaaaccaaACAGCGTTTAGCGCAAATAAAGTTGCCCGTAAAGTccgcagcaggagcaacagtcgcaacagcaactgttgctacCACGCACTGTGCgccagcaacaattgcaatgcgCCAAATGAATCAGAtccatcagcaacagcagctctaTGCTAAGAATGTGgtcaaaaacaataatgctggcaacaacatcaacatcaacaacagcaacagcatcaacaacagcaacagcaataacaatgcaaatttgGCTCCAGGCTGGCGTCGACtaaccaacaacaatgaagTGGCCTACATCAGTCCGACGGGCAAAACGCTGCGTACACAATTGCAAATCAAGGACTATTTGCTAACACAGGGTACCTGCAAGTGCGGCCTGCCATGTCCGCTGAGGCCGGAATactttttcgattttaatGCACAGGTAAGTTAG
Protein Sequence: MAAASAGQQLQQQQQQQQQQTQHKLNIVGVGNAETVAGVLQVNNELQQQQQQLNMYKQQQQQQLLQQQQQQFYQQQTKFVSRVVTNAAAMQSQQQQQQQQQILPAGLVNGSTNMMQATNVAVQQQQQQQQQQQQQQPQQLRHSQHIFVCPSIGTQLQQQQQQQQQLQQQQQTKQRLAQIKLPVKSAAGATVATATVATTHCAPATIAMRQMNQIHQQQQLYAKNVVKNNNAGNNININNSNSINNSNSNNNANLAPGWRRLTNNNEVAYISPTGKTLRTQLQIKDYLLTQGTCKCGLPCPLRPEYFFDFNAQVS

Sequence clustering based on sequence similarity using MMseqs2