Dleo006537.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Drosophila leonis
Gene Symbol
ken1
Assembly
GCA_035045365.1
Location
JAWNPC010000262.1:15140890-15143262[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 12 0.022 1.7 9.5 7.0 3 23 251 271 249 271 0.96
2 12 0.00023 0.018 15.7 0.9 1 23 277 302 277 302 0.94
3 12 0.018 1.3 9.8 0.2 2 23 310 334 309 334 0.92
4 12 0.00061 0.046 14.4 5.1 1 23 344 366 344 366 0.97
5 12 0.00022 0.017 15.8 1.9 2 23 374 395 373 395 0.96
6 12 0.0076 0.57 11.0 0.5 1 23 401 423 401 423 0.97
7 12 0.021 1.6 9.6 2.6 1 23 429 452 429 452 0.97
8 12 0.0016 0.12 13.0 1.9 1 23 458 480 458 480 0.97
9 12 0.0046 0.34 11.6 0.6 2 23 487 508 486 508 0.97
10 12 0.00019 0.015 16.0 0.8 1 23 597 620 597 620 0.95
11 12 0.1 7.5 7.4 1.3 1 21 626 645 626 648 0.75
12 12 6.6e-05 0.005 17.4 2.2 1 23 654 677 654 677 0.98

Sequence Information

Coding Sequence
ATGAATGAAGGGAGTGAGTACTCCATACACTCGATATGTCGCATATGCTTGAATCATTTGCGAAACGATCCGCCATACGACCTGTTTCTTGTCCCTGGTCTGGCCAagaaactgtgtgtgtgcacctcCCTCTCAGTGGAACAGCACGATGGCTTCCCGAAAAACCTTTGCTCAACTTGCTATACGCGGCTCAACGACTTGCATGGATTTCAAAAGCTTTGCGTGGACTCTGTGCAAAAGTTTCAAGAAATGGTCGCGAGCAATTACTTTGCCCCAGCTGTGGGCGATGTTGACAAGGTTGACGTAGTGCATGATGCAGCGGCTGATGGAGACATGGAAGAGGATCGTTCAAGCTTCGATCCACTCCTAAATACTAAAATAGAGATCGTGGAGACTGAAGATGTTTTTAAAATGCTGGATGATGTGGACAGAGAAGTGGAGGATGCTGAGAAGGAGCTCTCAAGTGATGCTGATTTCGAGAATGATGACGATCCAGAATTTGAAGTAAATAGTAGCAGCTCTGATGATGCTGTGCCCCTGTCCCGCTTACGAAGTGTGACCCGAGCATCGAAAGCAAAAACCAAGAGCAAACCTGTAGTAGATGATGACGATAATGATGACTCTTCTAGCTTTGAGTGGAATACCAATAATGATGAGAGCAAGGAAAAACctaaaatgaaaacgaaaactaAACCGAAACGTAAACGCATGCCAAGGGGCGAGGCATCATTGGATTCTGATCAGATTGATTGCCACATTTGCCATAAGAAATTCAAGAGCACAAACCTTTATGACGAGCATATGAAGCATCATAACGATCTTCTGCCTTTCCAGTGCACTATAGAAACCTGTAAGAAGGGCTTCACTACGTCTGGTGGACTGCGGCTTCACATGGATCACGCTCATTCGGAACTCTCGGCGGTGCACGCCTGTTCTGTTGAGGGATGCGGCATGACATTTCCTCGACCTGTTCTACtaacatttcatttgaagAAGGTGCACAAAATTATCACCTCTCGGGCCAAGGATCATCCTTGTACGGAATGTGATAAGGTGTTCCGCTGCTCAACGGCCCTCAAGAAACATATGTACAAGCATACGGGAGAGGAGAAGCCCATTTCCTGCAACATCTGCAACAAGCGCTTCCACATAAACAGCGAACTCAAGGATCATCTCTTGCGTCATGCCGGGGTGAAGAATCACGTTTGTCCTTACTGCGGCGTGGGCAAGACAACTCGACAGGAATGGAATAAGCATATATTGACGCACACCAAGGAGAAACAGTTCCAGTGTCGTCAATGTGATCATTCGTCCCACAACAAACAGGCTCTGGCCAATCATGTCAAAGTGGTTCATATGAAGATCAAGAATTACGCCTGTCAGTATTGCGGCAAGACCTTTGGCAAGTCGTATGCTTGCAAGATCCACGAGAGAATCCACACTGGAGAAAACTGTTCTCAGTGTAAAATCTGTGGTAAGGTCTTACTTTTTGAGAGGAGCTTGACCAAACATCTGAAGATTCATGAGAAGCGCGATCTACGCGCATCAGCGACCACTGTGAAACCACAGACCGTTGATGATGCGCAAGGCAGCCAGGATATGAATCGAGATGTGCCGGAGCCAGTGGAGATGAAGCCCATACCAACAGAGCACGTCAGGCCGAAAAATTCAAATAGGCTGGAGCGTGTGGATATATCCGAGTTAGCCGGTACCGCTGTCAATCCCATTCCGACAGTCTCTGTGGCATCCTGGTCACCTCAAGTGAACTTCACCAAGAAGGAGGGCCAGCACATTTGTCCgggatgtgggcgtggcttcAATCATATTGGCAATATGAAGCTGCATTATAAGATCATACATGAGAAGGTAAAAGATTTCGCCTGTCGCTTCTGTCCCAAGCGATTTTCGAAGGCTCAAATCTTACGGCATCACGAATGGATCCATACGGGCGAAAAACCGTATGAGTGCAAGATATGTGGCAAACACTTCCGCCAGGAGCAAGTGATGAAGACGCATGTGAGAAAAGTGCATGAGAATCCGGCGAAGCCTCCGAGAGAACCAAAACCCCAAAAGTCTGCTAAAGAAAAAAGACCGAAGATGAACCTCAATACAACGCCACCGAAGATTCTTGATGAATACCAAGATCCTGCTGCAGAGCGTGCCGCAGCAACTGCTGCGTTGCTCGCCCAACAAATCGAAGAGGGTCAGGCGAAGCGCAAGGCCGAGGAAGAAGTTCGTAAGATCCAAGAAGCCGCGTGTGAACAGCTGCAGATGCTGCAGAAGGAACAGCTTATTGACAAGCTACCCAGTGATAGCTTTCAAGTAAAAAAGCCCAAAACAGGCATCAGTGTGGATGACCTCAAACAAGATTAG
Protein Sequence
MNEGSEYSIHSICRICLNHLRNDPPYDLFLVPGLAKKLCVCTSLSVEQHDGFPKNLCSTCYTRLNDLHGFQKLCVDSVQKFQEMVASNYFAPAVGDVDKVDVVHDAAADGDMEEDRSSFDPLLNTKIEIVETEDVFKMLDDVDREVEDAEKELSSDADFENDDDPEFEVNSSSSDDAVPLSRLRSVTRASKAKTKSKPVVDDDDNDDSSSFEWNTNNDESKEKPKMKTKTKPKRKRMPRGEASLDSDQIDCHICHKKFKSTNLYDEHMKHHNDLLPFQCTIETCKKGFTTSGGLRLHMDHAHSELSAVHACSVEGCGMTFPRPVLLTFHLKKVHKIITSRAKDHPCTECDKVFRCSTALKKHMYKHTGEEKPISCNICNKRFHINSELKDHLLRHAGVKNHVCPYCGVGKTTRQEWNKHILTHTKEKQFQCRQCDHSSHNKQALANHVKVVHMKIKNYACQYCGKTFGKSYACKIHERIHTGENCSQCKICGKVLLFERSLTKHLKIHEKRDLRASATTVKPQTVDDAQGSQDMNRDVPEPVEMKPIPTEHVRPKNSNRLERVDISELAGTAVNPIPTVSVASWSPQVNFTKKEGQHICPGCGRGFNHIGNMKLHYKIIHEKVKDFACRFCPKRFSKAQILRHHEWIHTGEKPYECKICGKHFRQEQVMKTHVRKVHENPAKPPREPKPQKSAKEKRPKMNLNTTPPKILDEYQDPAAERAAATAALLAQQIEEGQAKRKAEEEVRKIQEAACEQLQMLQKEQLIDKLPSDSFQVKKPKTGISVDDLKQD