Basic Information

Insect: Drosophila immigrans
Gene Symbol: ftz-f1
Assembly: GCA_963583835.1
Location: OY757141.1:22214972-22230466[+]

Transcription Factor Domain

TF Family: SF-like
Domain: zf-C4|SF-like
PFAM: AnimalTFDB
TF Group: Zinc-Coordinating Group
Description: The ligand binding domain of nuclear receptor steroidogenic factor 1 (SF-1): SF-1, a member of the nuclear hormone receptor superfamily, is an essential regulator of endocrine development and function and is considered a master regulator of reproduction. Most nuclear receptors function as homodimer or heterodimers, however SF-1 binds to its target genes as a monomer, recognizing the variations of the DNA sequence motif, T/CCA AGGTCA. SF-1 functions cooperatively with other transcription factors to modulate gene expression. Phospholipids have been determined as potential ligands of SF-1. Like other members of the nuclear receptor (NR) superfamily of ligand-activated transcription factors, SF-1 has a central well conserved DNA binding domain (DBD), a variable N-terminal domain, a flexible hinge and a C-terminal ligand binding domain (LBD). [1, 8, 3, 11, 6, 5, 12, 10, 9, 2, 4, 7]
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 3 3 1.8e+04 -6.3 22.5 48 164 25 150 4 161 0.41

2 3 2.5e-19 1.5e-15 57.5 0.5 1 79 325 402 325 421 0.75

3 3 1.6e-72 9.6e-69 232.7 1.1 157 408 542 786 513 788 0.90

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	3	3	1.8e+04	-6.3	22.5	48	164	25	150	4	161	0.41
2	3	2.5e-19	1.5e-15	57.5	0.5	1	79	325	402	325	421	0.75
3	3	1.6e-72	9.6e-69	232.7	1.1	157	408	542	786	513	788	0.90

Sequence Information

Coding Sequence: ATGTTATTAGAAATGGATCAACAACAGGCGACTGTACAGTTTATATCGTCGCTGAATCTCTCGCCGTTTAGCATGcagctcgagcagcagcagcccgcGAGTCCGGCgcacagcaacaccaacaataacaacacgaacaacgccagcagcaacaacagcagcaacaacagcagcaacaataacaacgataACGATACAAATGCATTGAGCAACTCTGATAACGATTACAGCGCCTACACGCTGCAGTTGAGCaaccatcaacaacagcaacagcaacagcaacatcacacgcatcaccaacaacaacaacaacaacaacaacaacaacattaccAACAACAGAATATTGCCAATAACAATGCGAATGCAGCGAACCAATTCAATGCGTCCTCCTACTCGTATATATACAATTTCGATTCACAGTATATATTCCCGACAGGCTACCAGGAGACAAACTCCTCGCACTCGCAGCAGAGTGGCAACGGTGGCAACGCCGGCAGCGCCGCCGGCCAGCTGCTGAACGGTGGCAACGCCGCCAGCGCTGGCGGCAACGGTTACATGTTGCTGCCACCAGGGGGCGgcacctccgcctccgcctcctccgGCCACATGTCAACCGGCAACGTTGgcggcaacggcggcggcTCGAGCGGCAACGGCGGCGCCTCGGGCGGCACCTCGGCCGGCGGTGGCCATCATGGCGGCACAAGCGCCAGTTCGGGCGGCGGGGAGGCCATCGACTTTAAGCATCTGTTCGAGGAGCTGTGCCCGGTGTGCGGGGACAAGGTGAGCGGCTATCATTACGGCCTGCTCACCTGCGAGTCGTGCAAGGGCTTCTTCAAGCGCACCGTTCAGAACAAGAAGGTCTACACCTGCGTCGCGGAGCGATCCTGCCACATCGACAAGACGCAACGCAAGCGCTGTCCATACTGCCGATTCCAGAAGTGCCTCGAGGTGGGCATGAAGCTAGAGGCGGTTCGAGCGGATCGCATGCGTGGGGGACGAAACAAGTTTGGGCCGATGTACAAGCGGGATCGGGCGCGGAAGCTGCAGGTGATGCGGCAGCGTCAGTTGGCGCTCCAGGCGCTGCGCAGTTCAATTGGGTCGGACATCAAGCCGACGCCGCTCTCGCCGGGCTATCAGCAAGCATATccaaatatgaatattaagcaagaaatacaaatacctCAGGTATCCTCACTCACACAGTCGCCGGACTCGTCGCCCAgtcccattgccattgccttgGGGCAGGTGAATGCGAGCGggggcggcggtggcggtgtgATAGCCACGCCCATGAATGCCGGCAACGTGAGTGGCGGTGGCAACGGCAGCTCCTCCTTgggcggcggcaacaacagcaacaacaacaacaacagtggcaacaacaacagcagcagcagcacaggcagcggcggcagcgccGGCGGCGGAGGTGGCAACAACGCTGGCGGTGGCGGCGCCGGCGgaggtggcaacaacaacaacagctccgATGGCCTGCAACGCAACGGAAACGgcggcaatggcaacagcaacagcagctgccacgAAACCGGCACGGGATCTCTGCAGAACACAGCCGAATCGAAATTGTGCTTCGATTCTGGCACGCATCCATCGAGCACAGCCGATGCGCTCATCGAGCCTCTGAGggtatcgcCAATGATACGTGAATTTGTGCAATCGATCGACGATCGGGAATGGCAGACACAACTGTTTGCGCTGCTGCAGAAGCAGACGTACAATCAAGTAACCGTGGATCTCTTTGAGCTGATGTGCAAAGTGCTCGATCAGAATCTGTTCTCGCAAGTGGATTGGGCAAGAAACACGGTCTTCTTTAAGGATCTGAAGGTGGACGATCAAatgaagctgctgcagcattCGTGGTCGGACATGCTTGTGCTGGACCATCTGCACCATCGCATCCACAACGGGTTGCCCGATGAGACGCAACTGAACAACGGGCAGGTGTTCGATCTGATGAGCCTGGGGCTGTTGGGGGTGCCACAGTTGGGCGACTACTTTAACGAGATACAGAATAAGCTGCAGGACCTCAAGTTCGATATGGGCGATTATGTGTGCATGAAATTCCTAATACTGTTAAATCCAGATGTACGCGGCATTGTCAACAAGAAGACCGTCTTGGAGGGGCACGAGAGTGTGCAGGCAGCGCTGCTGGATTACACGCTCACGTGTTATCCCTCAGTCAATGACAAATTCAGGAGGCTATTGAACATACTACCAGAGATCCACGCCATGGCCTCCCGTGGCGAGGAGTATCTGTACACAAAGCACTGTGCGGGCAGTGCGCCAACGCAGACGCTGCTCATGGAGATGCTGCACGCCAAGCGGAAGGTGTAA
Protein Sequence: MLLEMDQQQATVQFISSLNLSPFSMQLEQQQPASPAHSNTNNNNTNNASSNNSSNNSSNNNNDNDTNALSNSDNDYSAYTLQLSNHQQQQQQQQHHTHHQQQQQQQQQQHYQQQNIANNNANAANQFNASSYSYIYNFDSQYIFPTGYQETNSSHSQQSGNGGNAGSAAGQLLNGGNAASAGGNGYMLLPPGGGTSASASSGHMSTGNVGGNGGGSSGNGGASGGTSAGGGHHGGTSASSGGGEAIDFKHLFEELCPVCGDKVSGYHYGLLTCESCKGFFKRTVQNKKVYTCVAERSCHIDKTQRKRCPYCRFQKCLEVGMKLEAVRADRMRGGRNKFGPMYKRDRARKLQVMRQRQLALQALRSSIGSDIKPTPLSPGYQQAYPNMNIKQEIQIPQVSSLTQSPDSSPSPIAIALGQVNASGGGGGGVIATPMNAGNVSGGGNGSSSLGGGNNSNNNNNSGNNNSSSSTGSGGSAGGGGGNNAGGGGAGGGGNNNNSSDGLQRNGNGGNGNSNSSCHETGTGSLQNTAESKLCFDSGTHPSSTADALIEPLRVSPMIREFVQSIDDREWQTQLFALLQKQTYNQVTVDLFELMCKVLDQNLFSQVDWARNTVFFKDLKVDDQMKLLQHSWSDMLVLDHLHHRIHNGLPDETQLNNGQVFDLMSLGLLGVPQLGDYFNEIQNKLQDLKFDMGDYVCMKFLILLNPDVRGIVNKKTVLEGHESVQAALLDYTLTCYPSVNDKFRRLLNILPEIHAMASRGEEYLYTKHCAGSAPTQTLLMEMLHAKRKV

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00562522;
90% Identity: iTF_00520685; iTF_00614218; iTF_00614241; iTF_00562522; iTF_00562500; iTF_00589596; iTF_00589575; iTF_00509151; iTF_00509129; iTF_00595296; iTF_00595276;
80% Identity: iTF_00520685;