Basic Information

Insect: Drosophila siamana
Gene Symbol: ftz-f1
Assembly: GCA_035047445.1
Location: JAWNPP010000160.1:312920-326664[+]

Transcription Factor Domain

TF Family: SF-like
Domain: zf-C4|SF-like
PFAM: AnimalTFDB
TF Group: Zinc-Coordinating Group
Description: The ligand binding domain of nuclear receptor steroidogenic factor 1 (SF-1): SF-1, a member of the nuclear hormone receptor superfamily, is an essential regulator of endocrine development and function and is considered a master regulator of reproduction. Most nuclear receptors function as homodimer or heterodimers, however SF-1 binds to its target genes as a monomer, recognizing the variations of the DNA sequence motif, T/CCA AGGTCA. SF-1 functions cooperatively with other transcription factors to modulate gene expression. Phospholipids have been determined as potential ligands of SF-1. Like other members of the nuclear receptor (NR) superfamily of ligand-activated transcription factors, SF-1 has a central well conserved DNA binding domain (DBD), a variable N-terminal domain, a flexible hinge and a C-terminal ligand binding domain (LBD). [1, 8, 3, 11, 6, 5, 12, 10, 9, 2, 4, 7]
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 3 2 1.6e+04 -7.8 26.3 48 166 25 156 4 163 0.53

2 3 1.6e-19 1.3e-15 57.6 0.5 1 79 329 406 329 424 0.75

3 3 3.9e-73 3e-69 234.2 1.1 157 408 542 786 514 788 0.91

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	3	2	1.6e+04	-7.8	26.3	48	166	25	156	4	163	0.53
2	3	1.6e-19	1.3e-15	57.6	0.5	1	79	329	406	329	424	0.75
3	3	3.9e-73	3e-69	234.2	1.1	157	408	542	786	514	788	0.91

Sequence Information

Coding Sequence: atgTTATTAGAAATGGATCAACAACAGGCGACTGTACAGTTTATATCGTCGCTGAATCTGTCGCCGTTTAGCATGCacatcgagcagcagcagccagcgagtCCAGCgcacagcaacaccaacaacaacagcaacaacaataacaacaacaataacagcagcaacaatagcagcagtaacaacaacaacaatgacaacgataCAAATGCATTGAGCAACTCTGATAACGATTACAGCGCCTACACGCTGCAGTTGAAcaatcatcagcagcagcaacagcagcaacatcacacgcatcaccagcaacaacaacaacagcagcagcagcaacagcaacaacattaccaACAACAGAatattgccaacaacaatgcgaatgcAGCGAATCAATTCAATGCCTCCTCCTACTCGTATATATACAATTTCGATTCACAGTATATATTCCCGACAGGCTATCAGGAGACCAACTCCTCGCACTCGCAGCAgagtggcaacggcaacggcggcaacgcCTCAGCCGGTGGCACAGCCGCCCAGCTCCTGAACGGCAACGCTGGcagcgctggcggcggcggtggcggctaCATGTTGCTGCCACCAGCTGGCGGCACCTCCGCCGCTGGCCACATGTCAGGCAATGTGGGTCCTGGCTCCGCCGGTGGCGCCTCGGGCACCTCGGcgggcggtggtggcggcggcggtggccaTCATGGCGGGACAAGCGCCAGCTCGGGCGGCGGCGAGGCCATCGATTTCAAGCATCTGTTCGAGGAGCTGTGTCCCGTCTGCGGCGACAAGGTCAGCGGCTATCACTACGGCCTGCTCACCTGCGAGTCGTGCAAGGGCTTCTTCAAGCGCACCGTGCAGAACAAGAAGGTCTACACTTGTGTTGCTGAGCGATCCTGCCACATCGACAAGACGCAGCGCAAACGCTGTCCCTACTGCCGATTCCAAAAGTGCCTCGAGGTGGGCATGAAGCTGGAGGCGGTTCGAGCGGATCGCATGCGTGGGGGACGAAACAAGTTTGGGCCGATGTACAAACGGGATCGGGCGCGGAAGCTGCAGGTGATGCGACAGCGTCAGTTGGCGCTCCAGGCGCTACGCAGTTCAATTGGGTCGGACATTAAGCCGACGCCGCTCTCGCCGGGCTATCAGCAAGCATATccaaatatgaatattaagcaagaaatacaaatacctCAGGTATCGTCACTCACACAGTCGCCGGACTCATCGCCCAgtcccattgccattgccttgGGGCAGGTGAATGCGAGCGGGGGCGGCGGCGGTGTGATAGCCACGCCCATGAATGCCGGCAACGTGAGTGGCGGCGGTAATGGTAGCTCCTCCCTGGGCGGtggcaacaaccacagcaccaacaacggcggcggtaataacaacaacagcagcagcacaggcagcggcggcggcggaggtgGCAATAATGCTGGCGGTGGCAGCgcgggcggcggcggaggtggcaacaacagcactgaCGGCCTGCAACGCAACGGAAgcggtggcaatggcaacagcaacagcagctgccatgAAACCGGCACTGGATCTCTGCAGAACACAGCCGAATCGAAATTGTGCTTCGATTCTGGCACACATCCATCGAGCACAGCCGATGCGCTCATCGAGCCACTGAGGGTATCGCCAATGATACGTGAATTTGTGCAATCGATCGACGATCGGGAATGGCAAACGCAACTGTTTGCGCTATTGCAGAAGCAGACGTACAATCAAGTAACCGTGGATCTCTTTGAGCTGATGTGCAAAGTGCTCGATCAGAATCTGTTCTCGCAGGTCGATTGGGCAAGAAACACAGTCTTCTTTAAGGATCTGAAGGTCGACGATCAGATGAAGCTGCTACAGCATTCGTGGTCGGATATGCTTGTGCTGGACCATCTGCACCATCGCATACACAACGGTCTGCCGGACGAGACGCAACTGAACAATGGCCAGGTATTCGATTTGATGAGCCTCGGCCTGCTGGGCGTGCCCCAGTTGGGCGATTACTTCAACGAGCTGCAGAACAAGCTGCAGGACCTCAAATTCGATATGGGCGATTACGTGTGCATGAAATTCCTAATACTGTTAAATCCAGATGTACGCGGCATTGTCAACCGGAAGACCGTCTTGGAGGGGCACGAGAGTGTGCAGGCAGCTCTGCTGGATTACACGCTTACGTGTTATCCCTCAGTCAATGACAAATTCAGGAGGCTATTGAACATACTACCAGAAATCCACGCCATGGCCTCACGTGGCGAGGAATATCTGTATACAAAGCATTGTGCAGGCAGTGCGCCAACGCAGACGCTGCTCATGGAGATGCTGCACGCCAAGCGGAAGGTGTAA
Protein Sequence: MLLEMDQQQATVQFISSLNLSPFSMHIEQQQPASPAHSNTNNNSNNNNNNNNSSNNSSSNNNNNDNDTNALSNSDNDYSAYTLQLNNHQQQQQQQHHTHHQQQQQQQQQQQQQHYQQQNIANNNANAANQFNASSYSYIYNFDSQYIFPTGYQETNSSHSQQSGNGNGGNASAGGTAAQLLNGNAGSAGGGGGGYMLLPPAGGTSAAGHMSGNVGPGSAGGASGTSAGGGGGGGGHHGGTSASSGGGEAIDFKHLFEELCPVCGDKVSGYHYGLLTCESCKGFFKRTVQNKKVYTCVAERSCHIDKTQRKRCPYCRFQKCLEVGMKLEAVRADRMRGGRNKFGPMYKRDRARKLQVMRQRQLALQALRSSIGSDIKPTPLSPGYQQAYPNMNIKQEIQIPQVSSLTQSPDSSPSPIAIALGQVNASGGGGGVIATPMNAGNVSGGGNGSSSLGGGNNHSTNNGGGNNNNSSSTGSGGGGGGNNAGGGSAGGGGGGNNSTDGLQRNGSGGNGNSNSSCHETGTGSLQNTAESKLCFDSGTHPSSTADALIEPLRVSPMIREFVQSIDDREWQTQLFALLQKQTYNQVTVDLFELMCKVLDQNLFSQVDWARNTVFFKDLKVDDQMKLLQHSWSDMLVLDHLHHRIHNGLPDETQLNNGQVFDLMSLGLLGVPQLGDYFNELQNKLQDLKFDMGDYVCMKFLILLNPDVRGIVNRKTVLEGHESVQAALLDYTLTCYPSVNDKFRRLLNILPEIHAMASRGEEYLYTKHCAGSAPTQTLLMEMLHAKRKV

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00562522;
90% Identity: iTF_00520662;
80% Identity: iTF_00595296;