Basic Information

Insect: Drosophila helvetica
Gene Symbol: ftz-f1_1
Assembly: GCA_963969585.1
Location: OZ018401.1:59199196-59211102[+]

Transcription Factor Domain

TF Family: SF-like
Domain: zf-C4|SF-like
PFAM: AnimalTFDB
TF Group: Zinc-Coordinating Group
Description: The ligand binding domain of nuclear receptor steroidogenic factor 1 (SF-1): SF-1, a member of the nuclear hormone receptor superfamily, is an essential regulator of endocrine development and function and is considered a master regulator of reproduction. Most nuclear receptors function as homodimer or heterodimers, however SF-1 binds to its target genes as a monomer, recognizing the variations of the DNA sequence motif, T/CCA AGGTCA. SF-1 functions cooperatively with other transcription factors to modulate gene expression. Phospholipids have been determined as potential ligands of SF-1. Like other members of the nuclear receptor (NR) superfamily of ligand-activated transcription factors, SF-1 has a central well conserved DNA binding domain (DBD), a variable N-terminal domain, a flexible hinge and a C-terminal ligand binding domain (LBD). [1, 8, 3, 11, 6, 5, 12, 10, 9, 2, 4, 7]
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 3 2 2.5e+04 -14.8 23.3 62 124 107 170 4 186 0.44

2 3 8.1e-20 1e-15 58.6 0.8 1 79 347 424 347 445 0.76

3 3 1.6e-70 2e-66 225.5 1.4 157 409 557 802 542 803 0.92

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	3	2	2.5e+04	-14.8	23.3	62	124	107	170	4	186	0.44
2	3	8.1e-20	1e-15	58.6	0.8	1	79	347	424	347	445	0.76
3	3	1.6e-70	2e-66	225.5	1.4	157	409	557	802	542	803	0.92

Sequence Information

Coding Sequence: ATGTTATTAGAAATGGATCAGCAACAGGCGACCGTACAGTTTATATCGTCGCTGAATATATCGCCGTTCAGCATGCAactcgagcagcagcagcagcagcagccctcgAGTCCGGCTCTGGCCGCCAATCAGCAGCCCCAAACGGGCtccaacaacaccaacaacagcagcagtggcggcggcggcaacaacaataacaacaacaacaacgataaTGACGGAAATGGTCTTTCAAAATTCGAGCATGAATATAACGCGTATACGCTTCAGCTAGCCGGTGGTGGTGCAGGTGGGGCAGGAGGCACTGTCagtggcagccagcagcagcagcatcacagcacgcaccaccagcagcagcagcagcagcagcagcagcagtccgaCCAGCAGGGGCActaccaacagcaacagcagcagcagcagcaacagaataTTGCCAACAACGCCAACCAATTCAACTCCTCGTCCTACTCGTATATATACAACTTCGATTCACAGTATATATTCCCGACAGGCTACCAGGACACCACCTCCTCGCACTCGCAGCAGAGCGGCGGTgggggcggcggcggtggcggagCTGGCGGCAACATCCTCAACGGCAGCTCGGGCAGCAGCTCCGGCTATATGCTGCTGCCGCAGGCGGCCAGCTCCAGCGGCAACACCAATGCCGCCCACATGTCCTCGGCCAGCGGATCCGTTGGCAATGCCAGCGGCCCCaacggtggcggcggcggcggttcCGGCCCTGGCAATGCCATGGGCGGTACGAGCGCCACCCCGGGACACGGCGGGGAAGTGATCGACTTCAAGCACCTCTTCGAGGAGCTGTGCCCCGTGTGCGGCGACAAGGTCAGTGGCTACCACTACGGCCTGCTCACCTGCGAGTCCTGCAAGGGCTTCTTCAAGCGGACGGTCCAGAACAAGAAGGTCTACACCTGCGTGGCGGAGCGGTCGTGCCACATCGACAAGACGCAGCGCAAGCGGTGTCCCTACTGCCGCTTCCAGAAGTGCCTGGAAGTGGGCATGAAGCTGGAGGCTGTTCGAGCGGATCGGATGCGGGGTGGCAGGAACAAGTTCGGGCCCATGTACAAGCGGGATCGGGCGCGGAAGCTGCAGGTGATGCGTCAGCGACAGATCGCCCTCCAGGCGCTGCGCAACTCGATGGGCCCGGACATCAAGCCGACGCCGATCTCGCCGGGCTACCAGCAAGCATATCCAAATATGAACATTAAGCAGGAAATCCAAATACCTCAGGTATCCTCACTCACCCAGTCGCCGGACTCGTCGCCCAgtcccattgccattgcttTGGGCCAGGTGAATGCCAGCGCGGGAGGAGTGATAGCCACGCCCATTAATGCCGGAAACGGAGGcagtggtggcggcggcggcggtggcggcctGAACGGCCCCAGTTCCGTGGGCAATGGCAatagcagcaacggcagcagcagcaacaacaccgGCAGCAGCACAGGCAACGGGTCAGGTGGCGCCGGCGGTGGAGGTGGTGGCAACAATgcgggcggcggcggcggcaacaaCAGCTCCACCGATGGCCTGCATCGCAACGgcggcggcaacggcaactgcCACGAAGCTGGAATAGGATCTCTGCAGAACTCGGCCGACTCGAAACTGTGcTTCGATTCCGGCACTCATCCATCGAGCACGGCCGATGCGCTTATCGAGCCCCTACGAGTCTCACCGATGATACGAGAATTTGTGCAATCGATCGACGATCGGGAATGGCAGACGCAGCTGTTCGCGCTGCTGCAGAAGCAGACCTACAACCAGGTGGAGGTGGATCTCTTTGAGCTGATGTGCAAGGTGCTCGATCAGAATCTGTTCTCGCAGGTGGACTGGGCAAGGAACACGGTCTTCTTTAAGGATCTGAAGGTCGATGATCAAATGAAGCTGCTGCAACACTCCTGGTCGGACATGCTGGTCCTCGACCATCTGCACCATCGCATCCACAACGGGCTGCCCGACGAGACGCAGCTGAACAACGGTCAGGTCTTCAATCTACTCAGCCTGGGCCTGTTGGGCGTGCCGCAGTTGTCCGACTATTTCAACGAGCTGCAGAATAAGCTGCAGGATCTGAAATTCGACATGGGCGATTATGTCTGCATGAAATTCCTAATACTTTTGAATCCAACTGTGCGCGGCATTGTCAACAGGAAGACCGTGTCGGAGGGGCATGATAATGTGCAGGCAGCCCTGCTGGACTACACCCTCACCTGTTACCCTTCAGTCCATGAAAAATTCAGTAGGCTAGTGAACATCTTACCGGAAATCCATGCCATGGCCGCACGCGGCGAGGACCACCTCTACACCAAGCACGTTGCCGGCAGTGCACCCACCCAGACGCTTCTCATGGAGATGCTGCACGCCAAGCGGAAGGGATAG
Protein Sequence: MLLEMDQQQATVQFISSLNISPFSMQLEQQQQQQPSSPALAANQQPQTGSNNTNNSSSGGGGNNNNNNNNDNDGNGLSKFEHEYNAYTLQLAGGGAGGAGGTVSGSQQQQHHSTHHQQQQQQQQQQSDQQGHYQQQQQQQQQQNIANNANQFNSSSYSYIYNFDSQYIFPTGYQDTTSSHSQQSGGGGGGGGGAGGNILNGSSGSSSGYMLLPQAASSSGNTNAAHMSSASGSVGNASGPNGGGGGGSGPGNAMGGTSATPGHGGEVIDFKHLFEELCPVCGDKVSGYHYGLLTCESCKGFFKRTVQNKKVYTCVAERSCHIDKTQRKRCPYCRFQKCLEVGMKLEAVRADRMRGGRNKFGPMYKRDRARKLQVMRQRQIALQALRNSMGPDIKPTPISPGYQQAYPNMNIKQEIQIPQVSSLTQSPDSSPSPIAIALGQVNASAGGVIATPINAGNGGSGGGGGGGGLNGPSSVGNGNSSNGSSSNNTGSSTGNGSGGAGGGGGGNNAGGGGGNNSSTDGLHRNGGGNGNCHEAGIGSLQNSADSKLCFDSGTHPSSTADALIEPLRVSPMIREFVQSIDDREWQTQLFALLQKQTYNQVEVDLFELMCKVLDQNLFSQVDWARNTVFFKDLKVDDQMKLLQHSWSDMLVLDHLHHRIHNGLPDETQLNNGQVFNLLSLGLLGVPQLSDYFNELQNKLQDLKFDMGDYVCMKFLILLNPTVRGIVNRKTVSEGHDNVQAALLDYTLTCYPSVHEKFSRLVNILPEIHAMAARGEDHLYTKHVAGSAPTQTLLMEMLHAKRKG

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00581562;
90% Identity: iTF_00471643;
80% Identity: iTF_00517762;