Dgla009225.2


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Drosophila glabriapex
Gene Symbol
-
Assembly
GCA_035042305.1
Location
JAWNLN010000066.1:7225136-7229223[+]

Transcription Factor Domain

TF Family
MBD
Domain
MBD domain
PFAM
PF01429
TF Group
Unclassified Structure
Description
The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 1 8.9e-13 5.6e-10 38.6 0.0 7 73 291 353 286 356 0.88

Sequence Information

Coding Sequence
ATGAATTCGACATCGACAGACATATCTAGAGAAAGATCCAGCCGCTCAAATGACGCTCTACTAGGTTGGAGCGGCAATTTTCCGAATTTCTCGTCCATCTATATCCCGGAGAGCAACTCACACATGGCACAGCTGCCCACCGACTTAAAGGCCATTTGTGCCACTGGCCTAAGAATTTATCCTAGAGAGCAAAAGGAAGAGGAACAATCGCAGCCGCAGACGCAGCTGTCGTCAACGCCGTCGTCTGAATCTGATTCCCCCTCACCCgtttcaaaaatgaattcaggtctaacaacaacagcagcatcagccacaacaaacacaacagctAGTAGCACACATACCACAAATTTGACTGTGACAAGTCTAAAGAGTGCTACGCAGACAACCAACTCCAACTGCGATATCAACAACATCGGCgatatcaacaacatcaacgatATCAAAAATATCAGCAATAACGACAGCGGTTCAACCTCGATTCCAAGTGCAACATCTTCTCCGCAACCATCAGCAGAGCCAAGAACAGAATCAGAGCCACAAATCGATTTTGACAAGCAGaAGGAGGCGATGCTGTTAAAGCTCCTGCAAAACGGCAAACCCGATGcaggagaaggagagagaggcAGCATCCCGCTGAGCAAGCGCTCTCGTATGCGATTTATGTCCTATAGTACTTCATCTAGCGATGAGGCCAGCGAAACGACAAAGCGCCTCAAGAAATCAACCGACGACAAGGATCACCCACCCTGCATGCTGCAGATGCGCTCCAAATCGATGTACCAATTTGACCCCACTAGCAGTGATGCAAAGACGCCCAAACGCCGGCGCTCGGTTGCTGCGAACAAACTGCTGGCCACAGATCCCTTCTATTGCATGCCCTTTGAATACGGCTGGAAGCGTGAATTGGTGTTGCGCAGCAATTTGAACAATGCATGCCAGCAGGCCGACGTTATATTCATATCGCCGGGGGGCAAGAAGCTGCGCTCGAGAGATGACATTGTCCCACTGCTTGTGCCCGGTCTGTCAATTGATCATTTTTGCTTTAAGCCCCAACTTCAGAATGCTGGCGAGCATTATGAAACGGTCCGCCAGGGTCAGTCTGCTAAGGAACGTCGCAGATTGTTGGCCGCCacaaagcagcagaagcaacaagagcagcagcagccacaacaacaacaacagcagcagctggctaaCAGTATCGATCTTGGCCAACAAGCACCATCAACGCTAACACCCGTCTTCGGGAAACGTGTGCCTAAGCCTAAGGTGCCCAAGGGCGCTAGCCCGCCGCCCGAGGGTTGGACCGCAACGATGGCGGTTGAGGGAAATGCACGCGTCCTGGCTGCGAGCAATGGTAACAGCAGTGGCGGCATCGGCTCCAGCGCCGGCAAAAGCGCACGCAGACGTGGCAACCAGACGAACAAATCAACAAAGGCAGCACCAGAGCCGACGACGGCGGCGCAGTCGAAGCTGCCGCTCCAGCCGCAGTCAGCCGTTGAGACGATAATAACTTGTGCGAAATGCTTGCAGGCAATCAATAACCGCAATCAAGCTTTTCGTGTCGGGCTGAGTACTCTCGAGAGCTACATCTGCAAGCGCTGTGTTATGCCTGGCAGCAAGGCTTCCCTTTCGCCGCCAGCAGATATAGCCCGACAGAAGCAGGCACGTGGACCTGAacatgccaatgccaatgccaatgctaGTGTCAATGCCAATGTCAATGGAAATGGTGGAAACAATAAGCTGGATAAGGAAGTGATCGATGACAATGTGAACGCCGCCGGCAATGGGGTCATCGTCAAACAGATTGATTCTCCTGCACGTCGTGGTGGTAGAAAGATGACACCCAAGCCAATGGAGGTGGTTGTTATTAACGGTCGCAAGGCTGTCGCCGTTGCTGTCTCGCCACCGCGTACGCGTCCCCAAATACCACTCTTTACAGGCGATCCGAATGCGGGTAtcaatttaagatttttagCTAGACGCAACGCCGCAGCTAAGGAGAACCGTAACCAAGTCGTTGATTGCATTTCTGGTGGCAGCATGGGCTGCCAGCTGATGACGGCCATTATGAAGACGCTTGACCTGCACGAACGCGTGCGCTTGTCAAGTGTCTGCAAGACCTGGGCTATGATAGGCCGCGATAGGAGCGTGTGGCGTACGGTGAAGTTGCGCGATACGCACATCAGCAACTGGATGCTTCTGCTGCGTGACATGGCGCTCTATCGCACCGCCGAGCTCGATATGATGGGCGTGAGAATGGACCATCCAAAGATGCGCTTGGACGGTGATTTGCGAGTGTTGAAATCGTTGCGCATTGTACGCACCGATGCCAGCGAGGCGGAGTTTATCGAGACAATTGTGAAGCGCATGCCACAACTGCTGGAGCTGCGCACAACGTGCGTCAGTCGTACTCTGAATTTGGCCAACATCGAAACGATGttggatttgtgtgtgctgcgcaTTCGCATGCTGGAGCCGAAAGCCAGCATCATCTcattgccgccgctgcagAAATTGAGCTGCTTGCGAGAGTTGAGCTTGCGCGGCATTAGCAACATGGCTCAGCTGAAGCTGTTGCACCTGAAGAgattgcagcagctggagacGCTTGTACTGGGTTCCTGTCGCGGTATGAAGGTGGCAACGTTCGGGCAACAAATTCTGCCCAGTCTGAAGCGTTTGCGCCACTTGCGTTTGGAGAACCACCACAGCCATCGCTCATTCAATATAAAAGAGATCATGGATGGCATTGCCGCCGCTGGCGCTGTGAAGCGTGTCGAACTCATCAATGTCAACGTAAATGCGGAGTTGAGTCGTCAGTTGTCCGAGTGTAAATCGTTGCAGgagctgcttctgttgccaaATTTCCACAATCATACCGCCTATATGGTGCACTACATCATGCAGGCGATCAACGAGAACAGCGAACAGCTCAATGTGTTCCGCCTGGGGATCACCTACGAACTGCTCAGCGTGACTCGGGCATTGGCCATGATCCACGAGGACTGTGTGCCAGTGCTGCTGCCCATTCCGGGCGTTCCCGAAAATGATGTACTGAATGAGTCCGATGAGCCAATCGCCTATTTGCCGGTCGATCGGCTCGAATCGATTTTACACCACATGATGCCGCAGGCTTGGGTAACCGTTGCCAAAGTTTCACAGCTTGAGACAATCAATCTCAAATTCCTGGCGGCTCCATCCACCGACAAAGATGGATTTTCAAACACATAA
Protein Sequence
MNSTSTDISRERSSRSNDALLGWSGNFPNFSSIYIPESNSHMAQLPTDLKAICATGLRIYPREQKEEEQSQPQTQLSSTPSSESDSPSPVSKMNSGLTTTAASATTNTTASSTHTTNLTVTSLKSATQTTNSNCDINNIGDINNINDIKNISNNDSGSTSIPSATSSPQPSAEPRTESEPQIDFDKQKEAMLLKLLQNGKPDAGEGERGSIPLSKRSRMRFMSYSTSSSDEASETTKRLKKSTDDKDHPPCMLQMRSKSMYQFDPTSSDAKTPKRRRSVAANKLLATDPFYCMPFEYGWKRELVLRSNLNNACQQADVIFISPGGKKLRSRDDIVPLLVPGLSIDHFCFKPQLQNAGEHYETVRQGQSAKERRRLLAATKQQKQQEQQQPQQQQQQQLANSIDLGQQAPSTLTPVFGKRVPKPKVPKGASPPPEGWTATMAVEGNARVLAASNGNSSGGIGSSAGKSARRRGNQTNKSTKAAPEPTTAAQSKLPLQPQSAVETIITCAKCLQAINNRNQAFRVGLSTLESYICKRCVMPGSKASLSPPADIARQKQARGPEHANANANASVNANVNGNGGNNKLDKEVIDDNVNAAGNGVIVKQIDSPARRGGRKMTPKPMEVVVINGRKAVAVAVSPPRTRPQIPLFTGDPNAGINLRFLARRNAAAKENRNQVVDCISGGSMGCQLMTAIMKTLDLHERVRLSSVCKTWAMIGRDRSVWRTVKLRDTHISNWMLLLRDMALYRTAELDMMGVRMDHPKMRLDGDLRVLKSLRIVRTDASEAEFIETIVKRMPQLLELRTTCVSRTLNLANIETMLDLCVLRIRMLEPKASIISLPPLQKLSCLRELSLRGISNMAQLKLLHLKRLQQLETLVLGSCRGMKVATFGQQILPSLKRLRHLRLENHHSHRSFNIKEIMDGIAAAGAVKRVELINVNVNAELSRQLSECKSLQELLLLPNFHNHTAYMVHYIMQAINENSEQLNVFRLGITYELLSVTRALAMIHEDCVPVLLPIPGVPENDVLNESDEPIAYLPVDRLESILHHMMPQAWVTVAKVSQLETINLKFLAAPSTDKDGFSNT