Dfla005062.1
Basic Information
- Insect
- Drosophila flavopinicola
- Gene Symbol
- lz
- Assembly
- GCA_035042425.1
- Location
- JAWNLL010000187.1:40394-61942[+]
Transcription Factor Domain
- TF Family
- Runt
- Domain
- Runt domain
- PFAM
- PF00853
- TF Group
- Beta-Scaffold Factors
- Description
- The AML1 gene is rearranged by the t(8;21) translocation in acute myeloid leukemia [1]. The gene is highly similar to the Drosophila melanogaster segmentation gene runt and to the mouse transcription factor PEBP2 alpha subunit gene [1]. The region of shared similarity, known as the Runt domain, is responsible for DNA-binding and protein-protein interaction.In addition to the highly-conserved Runt domain, the AML-1 gene product carries a putative ATP-binding site (GRSGRGKS), and has a C-terminal region rich in proline and serine residues. The protein (known as acute myeloid leukemia 1 protein, oncogene AML-1, core-binding factor (CBF), alpha-B subunit, etc.) binds to the core site, 5'-pygpyggt-3', of a number of enhancers and promoters.
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 2 4 1.4e+04 -4.4 1.1 58 76 65 81 54 94 0.53 2 2 4.3e-71 1.6e-67 225.0 0.0 5 129 100 224 96 224 0.98
Sequence Information
- Coding Sequence
- ATGGTCACATCCTCGGCATCGCCAACGGGTACGGGCTGGTCGGCGCCGGGCGATTACAAGAGCGCCAGCACAGCGGTCGCAGCCGCAACGGTCATGTGCGAGGTCCTGCCATCGAGCAGCGCCAGCGTCGGCAGCAGCTCGCCAACAGGTGGCGCCAGCAATGGCACGGCCAACAGTGCGCACAGTGGTagcggcaacaaaaacaacaacaacagtagcagtagcaataacaacaacaacaacaacaacgctgtGCATCAGGATCTGCTGTGGATGGAGCGATTTGTGCTAGAGCGACAACAGGAATATCCAGGAGAATTGGTGCGTACGAGCAATCCGTACTTCCTCTGCTCCGCCCTGCCCACCCACTGGCGCTCGAACAAAACGCTACCGTTAGCCTTCAAGGTCGTCGCCCTGGCGGACGTCGGCGACGGCACCTATGTGACCATCCGGGCGGGCAACGATGAGAACTGCTGCGCCGAGCTGCGCAACTACACAGCCCAGATGAAGAACGGTGTGGCCAAGTTCAACGATTTGCGATTCGTGGGACGAAGTGGTCGAGGGAAGAGCTTTACGCTGACAATTACCGTTGCAACAAGTCCGCCACAGGTGGCCACCTATGCCAAAGCCATCAAAGTGACCGTCGATGGTCCAAGGGAGCCGCGCTCCAAAACAAGCCCACCCGGCGGCCCACAATATCGAGCACTCGGCCTCGGCCAGCGGCCATTCATCGATGGTTTCCCAAAAACGTTTCACGAACTGGAAAATCTACGCCGCTCAGCGAAggtggcagcagcgacaacggcagcggcggcagctgcggTATCGGTTGCATCCACGGGCAACACTCTGACCACAAACCCAGCCAGTGCTGCCCATCAATTGAGCAGCAATTACTCATCGTCGAACAGTACAATAAATTCGGATTGCCAGGGCTACAAGCCCAATGCGCCACAAATTCAAGGATCCGTTTCACCCATGTGCCGATGCATCGAAGCCAAAGAAGCGCCGAGCATCCTGTCCAAATGA
- Protein Sequence
- MVTSSASPTGTGWSAPGDYKSASTAVAAATVMCEVLPSSSASVGSSSPTGGASNGTANSAHSGSGNKNNNNSSSSNNNNNNNNAVHQDLLWMERFVLERQQEYPGELVRTSNPYFLCSALPTHWRSNKTLPLAFKVVALADVGDGTYVTIRAGNDENCCAELRNYTAQMKNGVAKFNDLRFVGRSGRGKSFTLTITVATSPPQVATYAKAIKVTVDGPREPRSKTSPPGGPQYRALGLGQRPFIDGFPKTFHELENLRRSAKVAAATTAAAAAAVSVASTGNTLTTNPASAAHQLSSNYSSSNSTINSDCQGYKPNAPQIQGSVSPMCRCIEAKEAPSILSK
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- iTF_01323158; iTF_00544996; iTF_00510311; iTF_00533577; iTF_00585739; iTF_00508879; iTF_00530045; iTF_00575350; iTF_00543517;
- 90% Identity
- -
- 80% Identity
- -